Репозитарій

Abstract

УДК 615.276:547.789:542.91

The aim of the work.To predict the mechanisms of antiсancer activity using modern web tools for the compound Les-6489.

Materials and Methods. Molecular docking of EGFR and HER2 tyrosine kinases was performed for compound Les-6489. To evaluate the stability of complexes with Les-6489, molecular dynamics (MD) simulations were performed using GROMACS 13, which is accessed through the SiBioLead server.

Results and Discussion. As a result of in silico studies, a mechanism of antitumor activity was predicted for the studied compound Les-6489, which is implemented by inhibiting EGFR and HER2 tyrosine kinases.

Conclusions.The obtained results may become a platform for further structural optimization of the identified thiazole-isoindole hybrid molecule in the development of modern anticancer agents

Abstract. The current challenges facing Ukrainian society require precise attention to the demographic situation, particularly to a significant decrease in the birth rate in Ukraine, which in recent years has been associated with the COVID-19 pandemic and a full-scale war on its territory.

Purpose. Identify priority areas of the development of neonatological help in Ukraine at the present stage of reforming medical care to the population by using the analysis of the results of the questionnaire for doctors, including health policymakers.

Object and methods. The material of the study was a self-developed questionnaire. The online part of the survey during 2022-2024 involved 410 respondents. The study uses the following methods: system approach and analysis, medical-statistical and sociological methods.

Results. The analysis of the key problems of the system of medical care for mothers and children determined by the respondents showed that the main issue is (and remains) the lack of financial resources to ensure the effective functioning of the health care system from state sources of funding, including mothers and children – 67.16±2.33%. When distributing by importance, respondents emphasized the importance of preparing strategic plans for the functioning of the healthcare system, both at the state and local levels, that included preparation of medical assistance for mothers and children (50,37±2,48% stated that), the highest level of that statement was found amongst people with absent experience in the specialty “Organization and management of health care,” as well as with work experience up to 10 years.

Conclusions. The formation of analytical and strategic processes for planning medical care for mothers and children, as well as further study of existing challenges and needs will allow the implementation of appropriate organizational approaches in medical care for mothers and introducing measures aimed at creating conditions for safe birth and obtaining highly qualified medical care in medical institutions.

Introduction. The study of the population's mental health outlines a systematic analysis of the study's results on the determinants of its impact and the identification of potential determinants for building effective mechanisms to reduce their adverse effects. In Ukraine, the state of mental health of the population is affected by such global factors as full-scale military operations.

Objective. To study the role of public (social) determinants in influencing the state of mental health of the population during the war in Ukraine.

Materials and methods. The study was based on a survey of healthcare professionals to assess the level of influence of social determinants on the state of mental health of the population. The research methods used were bibliosemantic and sociological surveys, and two statistical analysis methods were a description of the study and an analysis of the facts obtained.

Results. It has been established that the critical social determinant of the impact on the state of mental health in Ukraine is the war with Russia. Based on this, the authors identified specific determinants that are closely related to this fact, namely the impact of the political situation, the effectiveness of public administration, the level of democracy, social conflicts, the organization of social protection, inflationary processes, corruption, migration processes, crime, and the organization and accessibility of the healthcare system. The assessment results showed that, according to healthcare professionals, the state of mental health is most affected by such factors as corruption (3.71±0.07 points out of 5 maximum), inflationary processes (3.58±0.07), and political situation (3.54±0.07). Respondents with less than ten years of work experience scored highest for all these factors. Social determinants: "Social conflicts in the environment," "Organization of social protection of the population," "Crime," and "Migration processes" were significantly more often mentioned by healthcare workers with up to 20 years of work experience than with more than 20 years of experience. Heads of healthcare facilities primarily pointed to the influence of such social factors as "Corruption" (3.81±0.14), "State of organization and accessibility in healthcare system" (3.74±0.13), "Political situation" and "Efficiency of public administration" (3.54±0.14 and 3.54±0.15, respectively).

Conclusions. The critical social determinants that affect the population's mental health are corruption in the state, inflationary processes, and the political situation. The correlation between the length of service and the position held regarding the level of assessment of the impact of social factors is revealed.

The monograph contains the materials of the 4th International Conference "Advanced Polymer Materials and Technologies", which was held on October 11, 2022 at the Kyiv National University of Technology and Design together with the Lviv Polytechnic National University. The monograph deals with the creation of new polymer composite materials and their processing technologies using extrusion, electroforming, 3D printing, and other methods; development of environmentally-oriented technologies and equipment for the production of polymeric materials for various purposes, including biodegradable ones. Considerable attention is paid to the creation of new polymer composite materials, in particular for environmental protection, using waste from the chemical industry. The monograph will be useful for teachers, students and graduate students, scientists and manufacturers whose activities are related to the above mentioned topics.