Важливість відновлення та збереження національної пам'яті нині постає з особливою гостротою, адже росія розв'язала проти України криваву війну, мета якої полягає у цілковитому знищенні української нації як самостійної спільноти у колі європейської цивілізації. Кремль чинить геноцид супроти українців, теро- ризує голодом різні країни і погрожує світові ядерною зброєю. Але прагнення українців до Свободи переростає у консолідовану спільно дію і кожен на своєму фронті пришвидшує Перемогу.

Збірник містить дослідження науковців із проблематики відновлення на- ціональної пам'яті, російського тоталітаризму, рашизму, імперіалізму, необхід- ності подолання зросійщення усіх сфер суспільного і культурного життя, персо- налістики, лінгвоциду української мови, а також матеріали із протидії російської пропаганди та дезінформації.

UDC 617.55-002.5-07:616.155-097.36-07

Despite the high level of development of modern diagnostics, there is still a problem of diagnosing extrapulmonary and latent forms of tuberculosis. The purpose of the study was to determine the features of the immune status during the Koch immunoprovocation test. Studies were conducted in the venous blood of 50 patients with abdominal tuberculosis before and 72 hours after the Koch skin test. Indicators of cellular immunity were determined by the indirect immunofluorescence method and the content of cytokines by the immunoenzymatic method. The existence of statistically significant differences in the immunogram and in the cytokine profile of the examined patients before and after the Koch test was proved. The Koch immunoprovocation test
exacerbates the pathogenetic manifestations of the chronic inflammatory process, which is manifested by a change in the cytokine spectrum of the blood and makes it possible to clarify the diagnosis of abdominal tuberculosis. Determination of the level of TNFα in the blood serum of patients after the Koch test can be a marker of the latent form of the course of abdominal tuberculosis. Key words: immune system, cytokines, extrapulmonary tuberculosis, Koch test. 

Background. The impact of the standard balneotherapeutic complex at Truskavets' Spa on physical performance in both rats and resort patients yielded mixed results. Previous research has indicated that the phytoadaptogen “Balm Truskavets” can mitigate the negative effects of Naftussya bioactive water on dynamic muscle performance in healthy rats and patients with post-radiation encephalopathy. This study aims to evaluate the potential of this phytocomposition to prevent unfavorable actotropic effects of Truskavets’ Spa balneofactors on gastroenterologic patients. Material and methods. The study observed 40 former female athletes (aged 30÷76 years, body weight 55÷98 kg) with chronic cholecystitis in remission phase, undergoing rehabilitation at Truskavets' Spa. Parameters including PWC150, adaptation hormone levels, HRV, EEG, immunity, metabolism and gas discharge visualization (GDV) were recorded. Members of the control group received for two weeks standard balneotherapy: drinking of Naftussya bioactive water, application of Ozokerite, baths with mineral water, therapeutic physical education. Members of the main group additionally received a phytoadaptogen. Results. The analysis of individual changes revealed that normal levels of PWC in control group fell to the lower zone of the norm. Phytoadaptogen prevents PWC decrease. This is accompanied by the prevention of both a decrease in power spectral density (PSD) T4-θ EEG and VLF HRV, leukocytes level as well as area and symmetry of GDV, as well as an increase in vagal tone and entropy of HRV as well as a rightward shift in the symmetry of the virtual first Chakra of GDV. In addition, phytoadaptogen reverses balneotherapy-induced moderate decrease in the frequency of α-rhythm, PSD O1-β, sympathetic tone, serum levels of catecholamines, testosterone and IgG, activity of Na,K-ATPase of erythrocyte shadows as well as Energy of the first, third and fourth virtual Chakras. Phytoadaptogen potentiates the reduction of PSD P4-β, IgM and cholesterol as well as initiates the reduction of δ-rhythm variability, PSD of α-rhythm in C3, C4, P4 and Fp2 loci, entropy in F4 locus as well as serum potassium while increasing in serum cortisol and calcitonin, blood B-lymphocytes levels as well as PSD Fp2-δ. Conclusion. The phytoadaptogen "Balm Truskavets'" prevents the adverse effect of the standard balneotherapeutic complex of the Truskavets’ Spa on PWC by, apparently, its neuro-endocrine effects.

Background. It is known about wide variety of individual reactions to stress explained by genetics factors. On the other hand, it is also known about aerobic fitness variability between individuals. From the above it follows the hypothesis that inter-individual differences in normal conditions determine the characteristics of the body's response to acute stress. The purpose of this study is to test the hypothesis. Material and methods. The experiment is at 58 rats (28 males) Wistar line. Animals were tested for resistance to hypoxic hypoxia and aerobic muscular performance by swimming test. On the basis of the received data two qualitatively equivalent groups in a ratio 10/48 were formed. After a week of recovery over the next 10 days, one animal remained intact and 5 other rats were exposed to water-immersion and restraint stress. The next day after stress, the ECG recorded and some endocrine, metabolic and immune parameters determined as well as erosive-ulcerative lesions of the gastric mucosa evaluated. Results. Four clusters by hypoxic and swimming tests were created retrospectively: normal resistance to hypoxia and muscular endurance (n=11); moderately reduced resistance to hypoxia and normal swimming test (n=25); drastic increased swimming test and normal hypoxic test (n=3); significantly increased resistance to hypoxia and normal swimming test (n=9). Each cluster is characterized by specific (correctness of classification 100%) post-stress changes in 6 neuro-endocrine, 12 immune, 10 metabolic and 2 ECGs parameters, as well as the index of damage to the gastric mucosa. The swimming test determines the post-stress state of the registered parameters by 63,8%, the hypoxic test - by 57,5%, and taken together - by 79,1%. Conclusion. The post-stress neuro-endocrine, immune and metabolic parameters as well as injuries of myocardium and gastric mucosa in rats are determined significantly by innate muscular endurance and resistance to hypoxia.

The first scientific publication on general adaption syndrome, or as we know today biologic stress has been published in Nature in 1936 by the 29-year old Hans Selye.1 Szabo et al2 in the anniversary review "Stress" is 80 Years Old” conclude that despite the extensive and multidisciplinary research on stress during the last 80 years, a lot of basic and clinical research is needed to better understand the manifestations, central and peripheral molecular regulators of stress response, especially the modes of prevention/management of distress or its transformation into eustress and the treatment of stress-related diseases.

In the vast majority of publications on stress, the HPA-, HPG- and autonomous systems are the objects of research, while the place in the general adaptation syndrome of such important hormones as calcitonin and PTH has been studied only in a few publications. Another methodological shortcoming of most studies is that the subjects of analysis are limited to a single neuro-endocrine system.

Therefore, we set ourselves the goal: to analyze relationships between some adaptation hormones, HRV, calcitonin, and PTH as well as electrocardiogram and gastric mucosal damage in naїve and post stressed rats.