ABSTRACT
The aim: To study medical and pharmaceutical specialists’ approaches to outpatient injection treatment and their impact on the quality of medical care.
Materials and methods: The object of the study was the answers of health care professionals (n=1408) to the questions on the use of injectable pharmacotherapy in personal treatment, listed in a specially designed questionnaire on a single protocol. System analysis, questionnaire survey, statistical, comparative-and-analytical methods were used.
Results: The quality of outpatient injectable pharmacotherapy, according to the results of a survey of medical and pharmaceutical specialist, can be considered inappropriate, as in 52.9% of respondents the local adverse reaction were significantly more likely to develop compared to the respondents who did not have any local adverse reaction (χ2=21.7819, p<0.05). Most often, the following complications of injectable pharmacotherapy occurred in the analyzed respondents: pain – 45.8%; hardening – 28.3% and reddening – 21.7%. When conducting home-based treatment, 42.8% of the respondents involved persons without medical education for the execution of procedures, which is significantly more frequent (χ2=26.5556, p<0.05) in comparison with the respondents who invited medical personnel (27.0%) and used the method of self-injection (30.2%).
Conclusions: The results of a survey of medical and pharmaceutical specialists revealed that home-based injectable treatment, based mainly on their own experience, is common in the occupational environment of health care professionals.
The aim. To establish the prevalence of PMS symptoms and evaluate the medication management of this disorder in Lviv.Materials and methods. The objects of the study were: scientific publications related to the problem of PMS; the results (n=105) of the survey. Methods applied: systematization, generalization, comparison, questionnaire. The statistical analyses (descriptive statistics, univariable analysis using simple logistic regression, multiple logistic regression) were performed with SPSS Trial.Results. The prevalence of PMS among the surveyed was high (83.8 %). The most common complaints are abdom-inal and/or low back pain (46.6 %) and increased irritability/aggression (43.2 %). Almost half (46.6 %) of women who experienced PMS consult a pharmacist, and only 23.9 % seek medical advice. At the same time, 87.5 % (n=77) of women (among those suffering from PMS) use medicines to alleviate/eliminate the symptoms of PMS. Nonste-roidal anti-inflammatory drugs (77.6 %), sedatives (36.8 %), and complex herbal remedies that affect the genital system (18.4 %) are the most common drugs for PMS.Choosing the way of PMS management, 44.8 % of women would prefer herbal medicines to synthetic ones. Both previous using of synthetic drugs for PMS and adverse drug reactions to synthetic drugs have a statistically signif-icant contribution to a positive attitude towards herbal remedies (p=0.004 and p=0.026, respectively).Conclusion. PMS is a common medical and social issue. Achieving effective and safe medication management of PMS requires the joint participation of a physician, pharmacist, and the patient in terms of compliance and lifestyle adjustments.
Монографія присвячена узагальненню експериментальних досліджень впливу лікарського засобу з політропними фармакологічними властивостями вінборону на фармакодинаміку широковживаного нестероїдного протизапального засобу – ібупрофену. Представлено дані про вплив ібупрофену та його комбінації з вінбороном на шлункову секрецію, проліферацію та апоптоз епітеліоцитів шлунку. Проведено оцінку ефективності комбінованого застосування ібупрофену та вінборону в лікуванні експериментального ревматоїдного артриту за даними гематологічних, біохімічних та патоморфологічних досліджень. Монографія буде корисною для широкого кола лікарів-клініцистів, фармакологів, біохіміків, патофізіологів та здобувачів закладів вищої освіти медичного, фармацевтичного та біологічного профілів.
This monograph summarizes the experimental studies on the pleiotropic effects of vinboron on pharmacodynamics of ibuprofen which is a widely used non-steroidal anti-inflammatory drug. Data on the effect of ibuprofen and its combination with vinboron on gastric secretion, proliferation and apoptosis of gastric epitheliocytes are presented. The effectiveness of the combined use of ibuprofen and vinboron in the treatment of experimental rheumatoid arthritis was evaluated in hematological, biochemical and pathomorphological studies. The monograph will be of intersest for clinicians, pharmacologists, biochemists, pathophysiologists as well as for medical, pharmacy and biology students.
Flame retardants have attracted growing environmental concern. Recently, an increasing number of studies have been conducted worldwide to investigate flame-retardant sources, environmental distribution, living organisms’ exposure, and toxicity. The presented studies include the degradation of 4,40 -isopropylidenebis(2,6-dibromophenol) (TBBPA) by ozonolysis and photocatalysis. In the photocatalytic process, nano- and micro-magnetite (n-Fe3O4 and µ-Fe3O4) are used as a catalyst. Monitoring of TBBPA decay in the photocatalysis and ozonolysis showed photocatalysis to be more effective. Significant removal of TBBPA was achieved within 10 min in photocatalysis (ca. 90%), while for ozonation, a comparable effect was observed within 70 min. To determine the best method of TBBPA degradation concentration on COD and TOC, the removals were examined. The highest oxidation state was obtained for photocatalysis on µ-Fe3O4, whereas for n-Fe3O4 and ozonolysis, the COD/TOC ratio was lower. Acute toxicity results show noticeable differences in the toxicity of TBBPA and its degradation products to Artemia franciscana and Thamnocephalus platyurus. The EC50 values indicate that TBBPA degradation products were toxic to harmful, whereas the TBPPA and post-reaction mixtures were toxic to the invertebrate species tested. The best efficiency in the removal and degradation of TBBPA was in the photocatalysis process on µ-Fe3O4 (reaction system 1). Theexamined crustaceans can be used as a sensitive test for acute toxicity evaluation.