The rapid development of modern scientific medicine and practice (development of genetic engineering, coronary angiography, use of microprocessors (microminiature implant in eye retina, 3D-print of implants, prostheses) is connected with the scientific-technical progress in recent years, which gave impetus to introduction of extremely complex treatment and diagnostic methods. The use of high-tech medical equipment requires the implementation of modern sanitary and antiepidemic measures of disinfection and sterilization after each manipulation to prevent in-hospital infection/infectious diseases which are related to the grant of medicare (IHI/IPNMD). Every year in the USA, up to 2 million patients who received medical services are registered with IHI/IPNMD cases. IHI/IPNMD is the cause of increased mortality, disability, lengthens stay period of patients in hospitals, increases the financial burden on both patients and healthcare system. According to WHO data mortality from IHI/IPNMD among adult patients ranges from 18.5% to 29.6% and in countries with low- and middle-income level fluctuate in the range of 8.8%-88.9%. Thus, the vital issue today is to strengthen the control system over IHI/IPNMD at all stages of its spread, namely: early detection of sick persons and carriers among patients and medical personnel, monitoring resistance to antibiotics and control over their use in patients treatment, expanding the range of scientific research in the development of new groups of antibacterial drugs, compliance with the sanitary-epidemic regime in hospitals, including the elaboration of modern disinfectants and sterilization agents.