UDC 616.47-006.488:618.3-06

Abstract.  Pheochromocytoma (PHEO) manifestation can be triggered by many different factors, including infectious diseases. In 2019, measles continued to spread in global outbreaks around the world. According to WHO data, more than 60 % of all measles cases in European Region were reported in Ukraine, a leader in measles occurrence. Measles is a dangerous viral disease, which remains an overwhelmingly important problem for healthcare system. Measles cause various life-threatening complications, which not only affect patients’ health and decrease quality of their lives, but can also lead to onset of many other medical conditions. Authors provide an example from their own clinical experience, which they have observed during the measles outbreak. Patient D., 22 y.o., female, was admitted to Lviv Infectious Diseases Communal Clinical Hospital because of measles. Condition was followed by severe intoxication, fever, hacking cough, skin rash all over the body. On 4th day after the appearance of rash patient developed atypical hypertensive crisis: in supine position started severe tachycardia, thumping headache, tremor of proximities and whole body, arterial blood pressure increased to 180/110 mm Hg; after changing the sitting position, symptoms started slowly decrease, in this regard patient had to spend a few days crouched in bed, she also complained about exaltation, insomnia, psychic tension, asthenia. Patient has undergone surgical treatment — laparoscopic left adrenalectomy. Perform differential diagnostics of hypertension accurately, paying special attention to determining its’ reason. Take into consideration, that PHEO manifestation
and hypertonic PHEO crises can be provoked by multiple reasons. If PHEO is suspected, hormonal, visualization and morphological examination methods should be performed. Keep in mind, that PHEO can be a constituent part of number of hereditary diseases: MEN 2A, MEN 2B, Von Recklinghausen’s Disease (Neurofibromatosis 1)

Binge eating disorder (BED) and night eating syndrome (NES) are common eating disorders (EDs) in individuals with diabetes type 2 (DT2). They worsen metabolic control, have a negative impact on physical and mental health and reduce quality of life. The roles of appetite-controlling hormones – leptin and ghrelin – is not clear enough in EDs and need to be investigated in order to establish new approaches and markers of EDs. Aim: To assess the difference in leptin and ghrelin levels in DT2 patients with and without EDs. 57 patients with DT2 were involved in the study. After physical examination and screening
for EDs, blood samples for leptin and ghrelin measuring were obtained.
Results: 19 participants (33.3%) were screened positively for ED (BE or NES). Leptin levels were higher in participants with ED (p<0.05). Conversely, ghrelin levels were lower in those with BE or NES (p<0.05). Leptin level is increased in DT2 individuals with BED and NES, whereas ghrelin is decreased. Leptin and ghrelin alterations maintain emotional eating, increase the frequency of binge and night eating episodes. In screening for EDs, assessing leptin and
ghrelin levels will facilitate obesity reduction and improve metabolic control in diabetic patients.

Summary
Aim:
Improving the quality of diagnosis and treatment orthodontic pathology in patient with temporomandibular joint disorders.

Materials and methods: Analysis – to determine objectives and study plan; clinical-diagnostic methods that include dental and radiological examination (to establish the clinical diagnosis of patients with temporomandibular disorders), electronic axiography (to determine the features of the movements of the articular heads of the mandible), instrumental study the models of jaws in the articulator (to diagnose the state of functional occlusion), statistical (to calculate averages and assess the probability of the results).
Results: After developed and implemented algorithm total dental rehabilitation we have eliminated functional disorders in the masticatory muscles and temporomandibular joints, completely restored the lost function of the masticatory apparatus.
Conclusions: Creation of occlusal relations, which are harmoniously combined with the function of masticatory muscles and temporomandibular joints, allowed to achieve the long period of remission, absence of the complications and recurrences of the disease in the near and long term. These points became the criterions that improved effectiveness of scientifically based individual treatment of mandibular disorders.

Key words: temporomandibular joint disorders (TMDs), malocclusion, individual treatment management

słowa kluczowe: zaburzenia skroniowo-żuchwowe (TMD), wada zgryzu, indywidualizacja terapii

Context

SARS-CoV-2 infection was declared a pandemic in 2020 and affected millions of people worldwide. Angiotensin-converting enzyme-2 receptors, through which coronavirus enters the cells of different organs, have been detected in the thyroid gland. The most common cause of thyrotoxicosis is Graves’ disease in which thyroid-receptors antibodies (TRAb) stimulate the TSH receptor, increasing thyroid hormone production and release.

Case presentation

A 22-year-old woman had symptoms of palpitation, tremor, muscle weakness, anxiety and sleep disturbance. 3 weeks before the onset of these symptoms, the patient suffered from COVID-19, which lasted 14 days and was characterized by a course of moderate severity with fever up to 38°C, general weakness without shortness of breath. The patient had no pre-existing thyroid problems. Her TSH was <0.01 mU/L, FT4, FT3 and TRAb were increased. Antithyroid drugs, glucocorticosteroids and β-blockers were prescribed. During 3 months of treatment doses of methimazole, methylprednisolone and bisoprolol were gradually reduced due to the improvement of the patient’s condition and thyroid tests normalization.

Conclusions

COVID-19 infection can cause Graves’ disease and thyrotoxicosis. The onset of this disease after SARS-CoV-2 does not depend on the presence of pre-existing thyroid pathology and requires the appointment of glucocortisteroids.

Humic substances are a group of macromolecular compounds that are non-living organisms, but are products of plant transformation, animal and microbial residues in natural conditions. The studies revealed that humic substances extracted from sapropel have a wide range of biological properties: antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, membrane and hepatoprotective. They are capable to increase the activity of metabolic processes in the body and normalize the leukocyte blood formula in leukemia as well. The objective of our work was to determine the presence of photoprotective activity of products with different sapropel extract contents on the model of acute photodynamic skin inflammation in rats. Investigation of anti-inflammatory activity of sapropel extract gel samples was carried out on the model of ultraviolet erythema in rats, which was caused by the irradiator "Promin" ZEMI" with a mercury-quartz lamp of DRT 125-1 type. Complete healing of ultraviolet erythema was observed in the group of animals treated with the sapropel extract gel in concentration of 15% and 10%, respectively on the 6th and 7th days after ultraviolet - irradiation. It should be noted that according to the indices of anti-inflammatory activity and skinfold thickness, the comparison product was significantly weaker to the gels with the sapropel extract. The gel with the sapropel extract in 15% concentration showed the best results. Key words: humic substances, sapropel extract, gel, anti-inflammatory activity, UV- erythema