Метою цієї статті є аналіз клінічного випадку пацієнта із пейсмейкерною тахікардією. Пейсмейкерна тахікардія може розвиватись лише у пацієнтів із двокамерним або трикамерним кардіостимулятором та збереженим вентрикулоатріальним проведенням. Механізмом пейсмейкерної тахікардії є штучне ріентрі за участю кардіостимулятора. Ретельне дообстеження пацієнта, холтерівське моніторування ЕКГ та перевірка кардіостимулятора є основними стратегічними підходами для коректного встановлення діагнозу пейсмейкерної тахікардії та диференціації її із іншими видами аритмій. Для запобігання виникнення пейсмейкерної тахікардії необхідно бути добре ознайомленим із антитахікардитичними алгоритмами роботи кардіостимуляторів різних моделей. Першочергово рекомендовано завжди вмикати алгоритми автоматичної детекції та усунення пейсмейкерної тахікардії, чого переважно вже достатньо для коректної роботи пристрою. У випадку необіхдності варто додатково розглянути такі варіанти, як пепепрограмування післяшлуночкового передсердного рефрактерного періоду (PVARP) та А-В затримки. При адекватному програмуванні кардіостимулятора, повторних рецидивів пейсмейкерної тахікардії переважно вдається уникнути. Довготривалий прогноз у пацієнтів із пейсмейкерними тахікардіями є сприятливим.
UDC 619:616.98:578.833.1/.2:595.771:578.822.1:636:592.8/599
The active ingredient of the preparation Viroden, developed in Ukraine, is the mosquito densovirus. This virus has a wide tissue tropism and affects all phases of ontogenesis. It reproduces itself in the mosquitos salivary gland cells, but unlike arboviruses, it is harmless for humans and vertebrates. It is well established that simultaneous infection of an insect with different viruses is often accompanied by the phenomenon of interference, whereby the reproduction of one or both viruses is suppressed in the insects body. Consequently, it was reasonable to investigate the results of concurrent infection with an arbovirus and a mosquito densovirus. Laboratory experiments demonstrated that mosquito densovirus suppressed the reproduction of West Nile, Sindbis, and Batai viruses in the mosquitos body, resulting in a significant decrease in their infective titers as well as a reduction in the transmission factor during blood-feeding. The relevance of this research is determined by the increasing levels of biological threats posed by zoonotic transmissible viral infections common to humans and animals. According to the predictions of experts, in light of the processes of globalization and climate change, this may result in the emergence of new pandemics and panzootics
Rabies is an especially dangerous anthropozoonosis caused by viruses of the Rabdoviridae family, genus Lyssavirus, known for over 4,000 years. There is no effective antiviral treatment for rabies, although immunobiological drugs have been developed, the timely application of which can prevent a fatal outcome in humans. Protection of the population from rabies includes control of zoonotic reservoirs and sources of the pathogen infection. The aim of the study was to assess the epizootic-epidemiological situation of rabies in Ukraine and Poland, considering risks caused by the active phase of the Russian-Ukrainian war. A comprehensive epidemiological method was used to analyze state official data regarding indicators of the epizootic process of rabies, the number and nature of human injuries due to animal attacks, and to determine trends during 2021–2023. A comparative-descriptive technique was applied to compare the effectiveness of vaccination against rabies in domestic, pet, and wild animals and to assess the risks of changes in the epizootic situation. Since the 1940s, a natural focal ecotype of rabies has formed in the Eastern European region, where wild carnivores are reservoirs and pathogen sources. In Ukraine, combined foci are registered with the natural focal ecotype of rabies, involving dogs, cats, and large and small ruminants in the epizootic process. The epizootic rabies situation in Ukraine worsened during the war due to the disruption of animal vaccination, increased feral domestic and farm animals, especially in the combat zone, and the cessation of regulating the normative number of red foxes. The epizootological well-being in Poland could be compromised if the rabies disaster area spreads from the border territories of Ukraine. There are real risks of worsening the epizootic-epidemiological situation of rabies in Ukraine, posing a threat of transboundary spread to other countries.
Abstract: This study was conducted to determine the prevalence of calcium and vitamin D deficiency in school children aged 6 to 11 years in Lviv (Ukraine). The aim of this study was also to assess the effect of nutritional intervention and supplementation on serum calcium and vitamin D levels in children diagnosed with calcium deficiency. A 3 day diet was analyzed in 172 children. In 56 children with a deficiency of calcium and/or vitamin D, the level of total calcium, ionized calcium, and 25-hydroxyvitamin D in blood, as well as the calcium content in hair samples, was determined. Thirty children with confirmed calcium and/or vitamin D deficiency underwent a dietary intervention to increase calcium and vitamin D intake for 3 months. The study group (n = 15) was provided with a nutritional correction by modifying their diet with supplementation of calcium and vitamin D. The control group (n = 15) received only a diet modification. Decreased daily calcium intake was observed in 50.68% of boys and 70.71% of girls. A decreased level of daily vitamin D consumption was found in 84.93% of boys and 96.97% of girls. Among 56 children with insufficient daily consumption of calcium and/or vitamin D, 26.8% had reduced levels of total calcium in the blood, 16.1% had reduced levels of ionized calcium in the blood, and 48.2% had reduced levels of vitamin D. After 3 months of correction, normal calcium level was found in the hair of 10 students (66.7%) from the study group and in three subjects (20.0%) from the control group. Modification of the diet along with supplementation of calcium and vitamin D seems to be a more effective method for increasing the level of calcium among children aged 6 to 11 years.
Introduction. The range of medicines with various trade names is extremely large and constantly growing. This is the reason for inadequate selection of medicines and medical errors. The aim: To study the problems of the modern state of medicines naming and to determine the ways of its solution. Materials and methods. General scientific methods of cognition are used: analysis and synthesis, abstraction, deduction, modeling, generalization. The materials were publications from the Google Scholar and PubMed electronic search systems, the Crossref bibliographic database for the period 1984-2024. The following keywords were chosen: medicine and drug, naming, international nonproprietary names, trade name, original drug, generic, brand, branded generic, chemical name, medication error, drug information. Results. It was found that the huge number of trade names of medicinal products causes informational problems with possible clinical consequences. Today, there is no international regulatory system that would guarantee that the trade names of medicines from different manufacturers from different countries differed enough to avoid the risk of incorrect prescriptions due to confusion of their names. It is obvious that the breadth of the modern pharmaceutical market and the huge number of trade names of medicines on it are the reasons for their inadequate selection and medical errors. Conclusions. Based on the results of the study of the problems of the modern system of drug names, the possibility of errors in the use of drugs due to the similarity of their trade names, it is proposed to create, under the auspices of the WHO, a single global system of trade names of drugs based on the globally accepted system of international non-proprietary names, which consists of that the trade name must contain the international non-proprietary name and the name of the manufacturer. The unified global system of trade names of medicines will allow the doctor, pharmacist and patient to choose a generic medicine with a high-quality composition of the active pharmaceutical ingredient and auxiliary substances.