UDC 577.24:612.68:615.03:615.1

Опрацьовано методику кількісного визначення антидепресантів (Бупропіон, венлафаксин, доксепін, пароксетин, сертралін та флувоксамін) в складі таблетованих чи капсульованих лікарських форм методом ВЕРХ з використанням твердофазної екстракції (ТФЕ)

Introduction. The increasing number of complications with blood transfusions has led to an increased risk of mortality and the need for complex, expensive, long-term treatment. Auto blood is an alternative method for managing intraoperative blood loss, potentially reducing these risks.
Preoperative auto-blood deposition minimizes the need for allogeneic blood transfusions in various surgical procedures. Studies have shown mixed results regarding its efficacy and safety.
The aim of the study: To evaluate the benefits of preoperative auto-blood collection followed by intraoperative infusion for patients diagnosed with abdominal aortic aneurysms and T2DM, especially when compared to alternative methods of blood loss management.
Materials and methods: 341 case histories of patients aged 56 to 73 years were carefully analyzed, with a distribution of 67 women and 274 men. The treatment was performed in the Department of Vascular Surgery of the Lviv Regional Clinical Hospital for ten years, from 2014
to 2024.
Results. A retrospective analysis showed that successful surgical outcomes and postoperative recovery were strongly associated with proper blood loss management during surgery. Patients who underwent preoperative auto-blood collection did not have problems related to blood transfusions,
unlike those who received donated blood.
Conclusions. Using auto blood significantly reduces the likelihood of perioperative complications in patients with type 2 diabetes mellitus. This approach demonstrates a significant advantage over the use of allogeneic transfusions for patients undergoing surgery for uncomplicated
abdominal aortic aneurysms.
Key words: diabetes, autoblood, insulin resistance, cardiovascular diseases, varicose disease. 

This article presents the data on the effectiveness of the treatment complex we developed on the activity of bone remodelling markers in the oral fluid during the treatment of generalized periodontitis,depending on the blood group.

There has been an increase in reported TBE cases in Europe since 2015, reaching a peak in some countries in 2020, highlighting the need for better management of TBE risk in Europe. TBE surveillance is currently limited, in part, due to varying diagnostic guidelines, access to testing, and awareness of TBE. Consequently, TBE prevalence is underestimated and vaccination recommendations inadequate. TBE vaccine uptake is unsatisfactory in many TBE-endemic European countries. This review summarizes the findings of a scientific workshop of experts to improve TBE surveillance and vaccine uptake in Europe. Strategies to improve TBE surveillance and vaccine uptake should focus on: aligning diagnostic criteria and testing across Europe; expanding current vaccine recommendations and reducing their complexity; and increasing public education of the potential risks posed by TBEV infection.

Hair loss or alopecia is a common dermatological condition affecting up to 2% of the world population. It is often caused by hereditary factors, such as male or female pattern baldness, but it can also result from various environmental factors, an unbalanced diet, or chronic illness. While hair loss is not life-threatening, it can cause significant anxiety, depression, and other psychological problems, ultimately impacting an individual's quality of life. Various treatments for hair loss, including both synthetic drugs, such as minoxidil and finasteride, or medicinal herbs, have been approved by the Food and Drug Administration. Despite synthetic drugs' effectiveness, they may come with potential side effects. Natural remedies have been proposed as a viable option for treating hair loss because many chronic disorders can cause alopecia. As such, this review focuses on identifying alternative, efficient treatment agents with limited side effects. Specifically, it looks into medicinal plants as potential healing agents for treating hair loss. To gather relevant information for the study, multiple databases were searched, including Scopus, PubMed, and Google Scholar. A comprehensive search was conducted using a range of search terms, such as “hair loss”, “alopecia”, “natural remedies for hair loss”, “herbal treatments for hair loss”, and others to extract relevant scientific articles. Many medicinal plants and natural compounds have shown potential in reducing hair loss, thanks to their anti-inflammatory and antioxidant properties and the ability to improve local metabolism when applied externally. According to existing literature, herbal extracts and formulations derived from plants, such as Urtica dioica, Humulus lupulus, Serenoa repens, Vitis vinifera, Pygeum africanum, Cucurbita pepo, etc., as well as certain individual herbal compounds, micronutrients, bee products, and keratin, may be effective in reducing hair loss directly or indirectly. Research suggests that medicinal plants and a variety of natural compounds hold promise in promoting hair growth and preventing alopecia.