The aim of the work. Comparative analysis of the educational programs' components of higher education institutions of different subordination, which train specialists for the pharmaceutical industry, and study the experience of design and assessment of the similarity level of the components of these programs.Materials and Methods. The educational and professional programs "Pharmacy, Industrial Pharmacy" of higher education institutions, namely Lviv Polytechnic National University and Danylo Halytsky Lviv National Medical University, have been used. The research was conducted using content analysis, comparative analysis, decomposition, and modeling methods.Results and Discussion. The analysis of educational programs of specialty 226 "Pharmacy, Industrial Pharmacy," which provides training of specialists at the Lviv Polytechnic National University (bachelors and masters in pharmacy, industrial pharmacy) and Danylo Halytsky Lviv National Medical University (Masters of Pharmacy) testifies to a significant amount of similar educational components, especially the pharmaceutical directions, which is a positive sign for the creation of future Education Standards. However, it should be noted that in the educational-professional bachelor's program in pharmacy, industrial pharmacy provides a large number of disciplines for general and vocational training. These disciplines are necessary and compose a basis for future educational program components that directly affect the specialist's becoming in industrial technology of medicines. The acquired competencies will allow performing qualitative work qualitatively and successfully implementing the acquired knowledge in the conditions of industrial pharmaceutical production.Conclusions. The creation and approval at the state level of the Education Standard for specialty 226 "Pharmacy, Industrial Pharmacy" is an essential and relevant element in the development of pharmaceutical education in Ukraine, which will harmonize and lead to a single format and content list of components of educational programs, unify state certification and guarantee competitiveness in the labor market for all higher education applicants.

SARS-CoV-2 and side effects of SARS-CoV-2 vaccination show tropism to nervous system structures. Neurological side effects from the central and peripheral nervous systems have been observed quite rarely after vaccination against COVID-19 compared to a large number of vaccinated individuals. The article presents a clinical case of simultaneous damage to the central and peripheral nervous systems in the form of acute autoimmune inflammatory encephalomyelopolyradiculoneuropathy, which occurred after receiving the first dose of the BNT162b2 mRNA vaccine. The severe course of encephalomyelopolyradiculoneuropathy with peripheral tetraplegia, sensory disturbances, bulbar syndrome, and dysautonomia, followed by the occurrence of pneumonia, secondary bacterial meningoencephalitis, the need for longterm mechanical ventilation led to the occurrence of pneumothorax and multiple organ failure, which caused the patient’s death after one and a half months of intensive therapy. Thus, the acute autoimmune inflammatory encephalomyelopolyradiculoneuropathy can be considered as a probable rare neurological complication of SARS-CoV-2 vaccination with mRNA-based vaccines. Encephalomyelopolyradiculoneuropathy can have a severe course, accompanied by multiple complications and leading to death. Establishing of the causal relationships of the occurrence of rare neurological pathological conditions close in time to vaccination against SARS-CoV-2 with mRNA-based vaccines requires additional further researches. 

The literature data of the last three decades on the problem of comorbidity of multiple sclerosis (MS) and epilepsy have been analyzed, such as issues of pathogenesis, clinical course, prognosis, and treatment of this dual pathology. Epileptic seizures occur in 2–3% to 5.9% of patients with MS, which is 3–6 times more common than in the general population. The incidence of epilepsy raises with increasing duration and severity of MS, with its
progressive course, and also depends on the effect of drugs for the treatment of MS. There is no unanimity in the literature on the age and gender characteristics of the occurrence of  epileptic seizures in MS. Probable mechanisms of MS comorbidity and epilepsy are analyzed. Data on certain common pathophysiology of MS and epilepsy and the concept according to which the model of epilepsy in MS is considered as a network disease are presented. Data on clinical manifestations and diagnosis of comorbid MS with epilepsy are presented. Epileptic seizures can occur at any stage of MS: before the clinical manifestations, at the onset of the disease, in the late stages, or can indicate exacerbation of MS. Types of epileptic seizures with a dual diagnosis (MS + epilepsy) are diverse. The majority of patients (up to 87.5%) have focal seizures (aware or unaware) or focal seizures to bilateral tonic-clonic, and a small share of patients have seizures of unknown origin. Most researchers believe that patients with MS and epilepsy have a more severe MS course and a worse long-term prognosis. The main directions of MS treatment and the impact of such treatment on the development of epileptic seizures are highlighted. Data on the effect of some disease-modifying drugs for the treatment of MS on the course of epilepsy and, on the other hand, on the impact of some antiseizure medications on the course of MS are presented. It is concluded that patients with MS have individual profiles and interindividual variability of epileptogenicity. The principles of treatment of epileptic
seizures/epilepsy in patients with MS are proposed.

Taras I. Pupin, Zoriana M. Honta, Ihor V. Shylivskyy, Oksana M. Nemesh, Khrystyna B. Burda

ABSTRACT

This work presents an analysis of the literature data of modern scientific research regarding the assessment of pathogenetic mechanisms of the impact of adaptive stress response on the condition of periodontal tissue. Chronic stress and depression suppress the immune system, predetermine hormonal imbalances, lead to metabolic disorders in tissues and increase the risk of dystrophic and inflammatory processes in periodontal tissues. All this leads to impaired masticatory function, tooth loss, pronounced psycho-emotional instability and significant decline in quality of life. That is why the problem of studying the adaptive stress response of the body requires further research to gain a deep understanding of its role in the etiology and pathogenesis of dental diseases and justify effective treatment and prevention measures.

KEY WORDS: periodontal tissues, generalized periodontitis, psychoemotional stress, adaptation, maladaptation, psycho-emotional disorders.

Метою даного дослідження є аналіз епідеміологічної ситуації з ентеробіозу серед дівчат з патологією сечової системи і при ураженнях нижніх відділів статевої системи за даними баз літератури (PubMed, Google Scholar, ResearchGate, PLoS, Hindawi) та висвітлення результатів власних клінічних спостережень. Ми опрацювали понад 200 робіт, присвячених впливу ентеробіозу на розвиток апендициту, близько 70 робіт про виявлення відповідного паразита в жіночій репродуктивній системі і близько 50 публікацій щодо його виявлення в сечовидільній системі. Ми подали 4 клінічні спостереження щодо наявності ентеробіозу в дівчаток і підлітків. Навели фотографії гостриків у центрифугаті сечі й у нижніх відділах жіночої статевої системи з описами негативних впливів паразита на здоров’я дівчаток і підлітків. Ентеробіоз може бути першочерговим чинником хронічних запальних процесів сечової системи та нижніх відділів статевих шляхів у дівчаток і підлітків.

The objective is to study the epidemiological situation on enterobiasis among girls with urinary system pathology and lesions of the lower parts of the reproductive system by analyzing literature databases (PubMed, Google Scholar, ResearchGate, PLoS, Hindawi) and to consider the results of our own clinical observations. We have processed more than 200 works on the effect of enterobiasis on the development of appendicitis, about 70 works on the detection of this parasite in the female reproductive system, and about 50 publications on enterobiasis in the urinary system. We presented 4 clinical cases on the presence of enterobiasis in girls and adolescents. We provided photos of pinworms in the urine centrifuge and in the lower parts of the female reproductive system with descriptions of the negative effects of the parasite on the health of girls and adolescents. Enterobiasis can be a primary factor in chronic inflammatory processes of the urinary system and the lower genital tract in girls and adolescents.