In the problem of eczema, the vascular component of its pathogenesis is of the topical importance. It has been established that the immune conflict condition is accompanied by the intensification of production or release of a wide range of substances exhibiting vasoactive effect as well. In such cases, one can consider changes in the vascular wall with subsequent activation of the thrombocytic-vascular and coagulation links of the haemostasis. Disagreement of literature data, as well as the need for therapeutic correction of haemocoagulation disorders in eczema patients necessitated further in-depth study of this process.

Stevens–Johnson syndrome (SJS), which is a drug-induced disease in 50% of cases, is increasingly common in everyday practice. A determining role in the pathogenesis of pathological conditions (inflammation, shocks of various genesis, etc.) plays a unique extra- and intracellular messenger, i. e., the nitrogen oxide (NO) system acts as an endogenous regulator in various dermatoses. In physiological concentrations, NO interacting with reactive oxygen species exhibits antioxidant properties, in case of metabolic disorders associated with the NO accumulation in tissues, and said reactions promote highly toxic substances adversely affecting the disease course. The NO biological action wide scope determines the interest in studying the NO-NOS system (nitrate ions (NO3-), nitrite ions (NO2-)) in patients with SJS, which is accompanied by the involvement of all body systems and defines the disease prognosis.

Acne remain an immediate problem in dermatology due to the tendency for increase of severe forms with frequent recurrence and damage of significant skin areas, which are the causes of temporary impaired productivity and reduced social activity in patients. This determines its important medical and social role. The aim of our research was to study the indicators of skin and intestine microbiocenosis and immunological parameters in patients with acne.

The high incidence of acne among teenagers, adolescent and young people indicates an important medical and social significance of the problem. In literary sources there is only a few reports about the possible role of stress, neuroendocrine pathology and the development of metabolic syndrome in the pathogenesis of acne, but the given data are often contradictory and insufficiently reasoned, which determines the relevance of further research in order to optimize the treatment and prevention of exacerbations of dermatosis.

Urticarial vasculitis is an eruption of erythematous wheals that clinically resemble urticaria but histologically show changes of leukocytoclastic vasculitis that may be divided into normocomplementemic and hypocomplementemic variants.