SARS-CoV-2 infection, in the vast majority, affects adult patients. The severity of COVID-19 and mortality are directly correlated with the increasing age of patients and the number of comorbidities. However, with the further development of the COVID-19 pandemic, severe cases of COVID-19 have been reported in children. About 0.8-1% of sick children require hospitalization in an intensive care unit. The main syndromes that cause disease severity and mortality in children are acute respiratory distress syndrome, multisystem inflammation syndrome and multiple organ failure. The rapid development of severe respiratory failure and hypoxemia in respiratory distress syndrome leads to the use of various methods of respiratory therapy, and in case of their ineffectiveness to extracorporeal membrane oxygenation (ECMO). In our report, we present two clinical cases of successful use of ECMO in children with COVID-19, who developed severe ARDS.

Adenocarcinoma is the most common type of bronchogenic
carcinoma in pediatric patients. It often has a poor prognosis, and stage 4 of the disease is observed in approximately 50% of the diagnosed cases.1
We present the case of a 17-year-old female patient with a complaint of unproductive cough for 4 months, which intensified during exercises and air temperature changes. Intrusive cough, increased fatigue, and appetite and weight loss were observed. Chest X-ray revealed a right-sided pleural effusion. Drainage of the right pleural cavity was performed and Mycobacterium tuberculosis (Mbt) was detected in the exudate using polymerase chain reaction (PCR).

Abstract

Background: In children, facial neuropathy is the most common disease that occurs due to damage of the cranial nerves. Facial nerve palsy (FNP) in children can be congenital or acquired. Congenital FNP may occur at birth due to trauma and with certain genetic syndromes. Acquired FNP can be caused by HSV types 1,2, HHV-6, cytomegalovirus, EBV, VZV, the bacterium B. burgdorferi or can result from inflammatory diseases, trauma and tumors. Unilateral or bilateral FNP is the most common complication of Lyme disease in children. The study that was conducted by Furuta Y. et al. indicates that reactivation of VZV infection is an important cause of acute peripheral FNP in children aged 6-15 years. Case Report: We have described a rare clinical case of bilateral peripheral FNP in a 14-year-old child with a confirmed diagnosis of Lyme disease and reactivation of VZV infection. Conclusions: Prescribed therapy with doxycycline for 21 days and valaciclovir for 7 days made it possible to achieve functional recovery of nerve on both sides.