The aim: The purpose of this literature review is to shed light on the development of biochemical knowledge in the Lviv region and on prominent figures in the development of biochemistry during the Second World War.
Materials and methods: Review of literature published before 2020. We searched the literature using the search terms ‘biochemists’, ‘ Lviv National Medical University’, ‘second World War’.
Conclusions: The development of biological research in Lviv can be divided into two historical stages: 1) from the beginning of the founding of Lviv University in 1661 to the First World War; 2) between the First and Second World Wars and after the Second World War. Biochemical research was initiated at the Medical Faculty of Lviv University. In 1939, the Lviv State Medical Institute was established on the basis of the Medical Faculty of the University, where a powerful department of biochemistry functioned, which was headed by a worldclass biochemist – Jakub Parnas. 

Рatients with diabetes have more complications and higher mortality from COVID-19. This is due to the fact that diabetes impairs the immune response. Hyperglycemia causes a violation of the immune response, which in turn cannot control the spread of pathogenic microorganisms and therefore patients
with diabetes are more susceptible to infections. The purpose of the work ₋₋ analysis of bibliometric databases of literature on new developments in diabetes and COVID-19 and focused on clinical recommendations for patients with diabetes infected with COVID-19. The search methods included a literature review of scientific articles that studied diabetes and COVID-19. According to the results of the analysis of the articles obtained as a result of the search in the PubMed, SCOPUS, Web of Science, MedScape databases, a combination of the terms “diabetes and SARS-CoV-2”, “diabetes and COVID-19”, “pathogenesis of diabetes in case of COVID-19”, "pancreas", "clinical features", "diagnosis", "treatment", "clinical recommendations", we found 32 messages from 2020 to 2022. The main parameters  of the study were outpatients and inpatients with diabetes and COVID-19 of middle and elderly age starting from 46 years and up to 82 years of age in France, China, the USA, Great Britain, in which a nationwide, retrospective, populationbased study was conducted. The following concomitant diseases are included in the main studies: arterial hypertension, cardiovascular diseases, heart failure, chronic kidney disease, chronic obstructive pulmonary disease, myocardial infarction, cerebrovascular diseases. Issues of pathogenetic mechanisms in DM and COVID-19, as well as management of patients with DM and COVID-19 are highlighted.
Key words. Diabetes mellitus, СOVID-19, SARS-CoV-2, angiotensin-converting enzyme-2, cytokines.