Tubal factor infertility is one of the most pressing problems of our time, as this condition makes it impossible for a mature organism to produce offspring. The issue of restoring and preserving reproductive health is one of the priority problems of modern gynaecology and reproductive medicine. Therefore, in terms of reproductive health care as a fertility factor, the main focus is on those strategies that can help reduce reproductive losses. In recent years, Ukraine has been experiencing an insufficient level of reproductive health due to the negative impact of socio-economic instability in the country, martial law, falling living standards, and natural conditions. In addition, the ongoing opioid epidemic is a major burden on society and has a detrimental impact on future generations. Many literary sources contain information about the significant adverse effects of opioids on women's reproduction. The fallopian tube is crucial in the mother's interaction with gametes and embryos. For both human and female laboratory white rats, it takes almost four days for the oocytes to pass through the fallopian tube to the uterus. Defects associated with these processes can lead to infertility, which has motivated a wide range of research into the causes and treatments of pathological conditions of the fallopian tube.The article highlights the links of tubal-peritoneal infertility, namely the effect of the narcotic analgesic Nalbufin on the morphometric parameters of the components of the mucous membrane of the ampulla of the fallopian tube: the thickness of the mucous membrane, the thickness of the mucous membrane lamina propria, the width and length of the fold of the mucous membrane of the ampulla of the fallopian tube of the female white rat.