The aim of the study was to ascertain the current state of surgical care as resulting from the reformation of medicine and education in Ukraine and to recommend ways of advancing it. The research included the processing and analysis of the annual reports of the Urology department of the Municipal City Clinical Emergency Hospital in Lviv during 2010-2019. The main statistical indicators of rendering the surgical aid (surgical activity, the structure of surgical interventions, mortality and structure of mortality, which are used in quantitative assessment of quality of medical aid and submitted in the annual reports) were analyzed in this work.
The study has identified the main problems of surgical work of the healthcare facilities in the section of the Urology department of the Clinical Emergency Hospital in Lviv, the most important of which are the low indicator of surgical activity and the presence of postoperative mortality. The main mortality reasons of the patients of the Urology department of this hospital are neglected oncopathology or other concomitant pathology, multiple organ failure, septic condition. 
The key points towards resolving these problems are the further development of the material-technical base of the hospital and improvement of the overall quality of medical staff training, both during the undergraduate and postgraduate training of specialists, which will allow the improvement of the quality of rendering medical aid nationwide.

Abstract: Searching for new types of biological activities among preliminarily identified hit compounds is a key challenge in modern medicinal chemistry. In our study, a previously studied 3-[5-(1H-indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl]-propionic acid (Les-6614) was screened for antimicrobial, antifungal, anti-allergic and antitumor activities. Moreover, cytotoxicity, molecular docking, and, the SwissAdme online target screening were accomplished. It was determined that the Les-6614 has slight antimicrobial and antitumor activity. However, the studied compound decreased IgE levels in sensitized guinea pigs by 33-86% and reduced IgA, IgM, IL-2, and TNF-α, indicating anti-inflammatory and anti-allergic activities. According to the SwissADME web tool, target predictions Les-6614 potentially has an affinity for Lysosomal protective protein, Thromboxane-A synthase, and PPARγ. The molecular docking confirmed that the studied 2-thioxo-4-thiazolidinone derivative showed good bonding with LLP and TXAS leading to stable protein-ligand complexes. Also, the Les-6614 is a potential PPARγ modulator, which is important in the pathogenesis of allergy, cancer, and cardiovascular diseases.