The recent experience of using social media by the Ukrainian scientific and medical journal "Proceedings of the Shevchenko Scientific Society. Medical Sciences" DOI: 10.25040/ntsh (Medical Sciences) is presented, which have become important tools for increasing the visibility of medical journals. Social media have become an important tool for enhancing the visibility of medical journals. Social media facilitate the dissemination of knowledge, promote publications, engage audiences, and support the development of professional communities. Platforms such as LinkedIn, Facebook, and X (formerly Twitter) enable the formation of networks among authors, reviewers, and readers, help disseminate content, and contribute to establishing a positive image of the journal. Graphic abstracts are a promising tool for visual communication; however, they require standardized styles and the availability of consistent templates. A successful social media presence requires clear branding, high-quality content, bilingual communication, and a strategic approach. Although social media activity does not automatically lead to increased citation rates, it contributes to author promotion and the expansion of the journal’s reach. The mission of the "Medical Sciences" journal is to establish a global scholarly presence, foster open communication, and support Ukraine especially during wartime through scientific dialogue.
Keywords: medical science, medical journals, visual abstract, scientific writing, social media, communication, scientific publishing, journal club.

Abstract: A novel 4-thiazolidinone derivative Les-6490 (pyrazol-4-thiazolidinone hybrid) was designed, synthesized, and characterized by spectral data. The compound was screened for its antimicrobial activity against some pathogenic bacteria and fungi and showed activity against Staphylococcus and Saccharomyces cerevisiae (the Minimum Inhibitory Concentration (MIC) 820 µM). The compound was studied in the rat adjuvant arthritis model (Freund’s Adjuvant) in vivo. Parietal and fecal microbial composition using 16S rRNA metagenome sequences was checked. We employed a range of analytical techniques, including Taxonomic Profiling (Taxa Analysis), Diversity Metrics (Alpha and Beta Diversity Analysis), Multivariate Statistical Methods (Principal Coordinates Analysis, Principal Component Analysis, Non-Metric Multidimensional Scaling), Clustering Analysis (Unweighted Pair-group Method with Arithmetic Mean), and Comparative Statistical Approaches (Community Differences Analysis, Between Group Variation Analysis, Metastat Analysis). The compound significantly impacted an increasing level of anti-inflammatory microorganisms (Blautia, Faecalibacterium prausnitzii, Succivibrionaceae, and Coriobacteriales) relative recovery of fecal microbiota composition. Anti-Treponemal activity in vivo was also noted. The tested compound Les-6490 has potential prebiotic activity with an indirect anti-inflammatory effect.
Keywords: 4-thiazolidinones; antimicrobial activity; anti-inflammatory activity; metagenomic sequencing; rats; gut microbiota