Рatients with diabetes have more complications and higher mortality from COVID-19. This is due to the fact that diabetes impairs the immune response. Hyperglycemia causes a violation of the immune response, which in turn cannot control the spread of pathogenic microorganisms and therefore patients with diabetes are more susceptible to infections. The purpose of the work ₋₋ analysis of bibliometric databases of literature on new developments in diabetes and COVID-19 and focused on clinical recommendations for patients with diabetes infected with COVID-19. The search methods included a literature review of scientific articles that studied diabetes and COVID-19.
According to the results of the analysis of the articles obtained as a result of the search in the PubMed, SCOPUS, Web of Science, MedScape databases, a combination of the terms “diabetes and SARS-CoV-2”, “diabetes and COVID-19”, “pathogenesis of diabetes in case of COVID-19”, "pancreas", "clinical features", "diagnosis", "treatment", "clinical recommendations", we found 32 messages from 2020 to 2022. The main parameters of the study were outpatients and inpatients with diabetes and COVID-19 of middle and elderly age starting from 46 years and up to 82 years of age in France, China, the USA, Great Britain, in which a nationwide, retrospective, populationbased study was conducted. The following concomitant diseases are included in the main studies: arterial hypertension, cardiovascular diseases, heart failure, chronic kidney disease, chronic obstructive pulmonary disease, myocardial infarction, cerebrovascular diseases. Issues of pathogenetic mechanisms in DM and COVID-19, as well as management of patients with DM and COVID-19 are highlighted.

UDC 582.232:547.977:581.132:543.42

The physicochemical characteristics of phycocyanin extracted from cyanobacteria collected in Kaunas Lagoon were studied (spectrum characteristics, C-PC content in the dry mass and chemical purity). It was determined that the tested concentrations of C-PC in purified water should be in the range of 0.02–0.16% for measuring C-PC content in the dry mass and its spectrum characteristics. The two clear absorption maxima were detected in the spectrum of C-PC at the wavelengths of 277 and 619 nm. The content of C-PC in the dry powder form was in the range of 7.25% to 9.30% depending on its concentration in the solution and type of spectrophotometer. Furthermore, a purity factor of 1.5 was calculated, which indicated the food qualification of the obtained biomass of C-PC. Finally, the analytical procedure for studying the pro- and anti-oxidant activity of C-PC was developed and the antioxidant activity of C-PC was measured for the available markers. It was revealed that C-PC has dual properties (pro- and anti-oxidant ones) depending on its concentration,
more exactly, its content in reaction mixtures with 2,2-diphenyl-1-picrylhydrazyl (DPP H). The following issues were resolved during the research: the concentration of ethanol in the DPP H solution was chosen in order to avoid precipitation of proteins in the reaction mixtures (50%); the ratio of the solution of C-PC to the DPPH solution was selected; the selected concentrations of the markers for the construction of their calibration curves were chosen for quercetin and for rutin. The antioxidant activity of the obtained C-PC sample was determined

Abstract Spinal dysraphism (SD) or spina bifida (SB) is a congenital deformity that results from embryonic neural tube closure failure during fetal devel- opment. This evidence-based position paper represents the official position of the European Union through the UEMS PRM Section. This paper aims to evaluate the role of the physical and rehabilitation medicine (prM) physician and prM practice for children and adults with spinal dys- raphism. a systematic literature review and a consensus procedure involved all European countries delegates represented in the uEMs prM sec- tion through a delphi process. the systematic literature review is reported together with thirty-two recommendations resulting from the delphi procedure. The professional role of the PRM physician requires specific expertise in the treatment of patients with SD to plan, lead and monitor the rehabilitation process in an interdisciplinary setting and to participate in the assessment of the needs of these patients in the transitional phase from childhood to adulthood, with particular attention to the activity limitation and participation restriction.

(Cite this article as: petronic Markovic i, Nikolic d, stahl M, tederko p, hdyrya o, Negrini s, et al. Evidence-based position paper of the uEMs prM on the role of physical and rehabilitation Medicine (prM) physician in the management of children and adults with spinal dysraphism. Eur J phys rehabil Med 2022;58:511-9. doi: 10.23736/s1973-9087.22.07536-0)

Key words: spinal dysraphism; rehabilitation; physical and rehabilitation medicine; Guideline adherence; consensus.

Abstract  

Background. The article deals with the effect of physical therapy on students with vertebral artery functional compression syndrome. Constant stable flexion of the cervical spine is one of the functional factors that can cause deformation of the vertebral arteries and, as a consequence, to reduce blood flow through these arteries

The purpose of the research is to define the effect of physical therapy on vertebral artery functional compression syndrome caused by a violation of biomechanics in the cervical spine.

Material and methods. The research involved 24 students aged 18 to 23 years old. The research used the following methods: theoretical analysis and generalization of reference sources on the topic of scientific research, clinical evaluation of vegetative disorders with a questionnaire for determining signs of vegetative changes by O. M. Vein, comprehensive ultrasound examination of the head and neck blood vessels, goniometry of the cervical spine and mathematical statistics.

Results. Physical therapy helped to restore the volume of active movements in the cervical spine (p<0.05). The disappearance of the main symptoms was noted by an average of 74% of respondents, and the rest noted their decreased character. Peak systolic blood flow velocity in the vertebral arteries when performing functional tests increased (p <0.05).

Discussion. The positive results were achieved, probably due to the normalization of anatomical and functional interconnections in the cervical spine, stimulation of its reparative capabilities via manual therapy, namely post-isometric muscle relaxation.

Conclusions. The research results show that the use of physical therapy for patients with vertebral artery functional compression syndrome helps to reduce the clinical manifestations of the disease, restore proper spinal biomechanics and improve blood flow in vertebral arteries.

Key words: physical therapy, vertebral artery functional compression syndrome, post-isometric muscle relaxation, biomechanics of the cervical spine, goniometry of the cervical spine, ultrasound examination of the vertebral arteries.  

УДК 534.05:616-008.842/.848

The ever-increasing harmful effect of endo- (products of inflammatory processes of genital tissues) and exogenous factors (environmental conditions) on the body of women and animals (cows) leads to a substantial decrease in ova fertilisation during mating and artificial insemination. Therefore, the purpose of this study was to identify changes in the signs of physical condition (colour, consistency, fluidity, impurities, etc.) and ratios (homeostasis) of H2O mass, organic (OS) and inorganic (IS) substances of uterine-vaginal mucus (UVM) should be used to assess their harmful effect on the fertilisation of cows after their first insemination. The following methods were used for this study: ocular estimate of the physical condition of freshly obtained mucus; gravimetric assessment of the features of changed mass parameters of its dry residue (DR) components; mathematical and statistical analysis of certain indicators. Determined by the gravimetric method, the features of the imbalance of mass (g, mg), its distribution (%) and ratios (Im:1, Ic:1) in the system of the “medium — substance” type due to the harmful effects of endogenous factors (products of inflammatory processes) indicate that the secretions of the genitals released during oestrus are characterised not only by changes in signs, but also ±2-4 times different from the norm (control) indicators of the mass of components. Under such circumstances, the distribution of substances in the DR samples of the experimental group is expressed by the series, where the mass OS1˃IS˃OS2, but in the control group — OS1˃IS˃OS2. This means that the products of inflammatory processes released by the genitals of cows change the norm of homeostasis of the mass (distribution of components) of OS and IS of the biological system of the “medium — substance” type. Indicators of the obtained mass ratios between component pairs H2O: DR; H2O: OS2, H2O: OS1,H2O: IS (control group — 63:1, 586:1, 231:1, 109:1; experiment group — 42:1, 310:1, 87:1, 112:1), except for the H2O: IS pair (P˂0.05), indicate the presence of probable changes in the homeostasis of OS and IS in the “H2O — components” system. The high probability (P˂0.02; ˂0.001) of the detected changes is inherent in the “DR –components” system, namely: if the average ratio indicators of pairs DR: OS2; DR: OS1; DR: IS samples of the control group are 9:1, 4:1, 2:1, then the same indicators in the experimental group are 7:1, 3:1, 2:1, respectively