UDC  618.11-007.1 

Abstract. Polycystic ovary syndrome (PCOS), an endocrine and metabolic disorder in women of reproductive age, is characterized by high androgen levels, irregular periods, and small cysts in the ovaries. PCOS affects approximately 10 % of reproductive age women of all races and ethnicities. PCOS has been recognized to affect women of reproductive age since antiquity and in the 21st century, it emerges as the most widespread and serious reproductive metabolic disorder in the world. PCOS is a multifactorial disorder that affects both the reproductive and metabolic health of women. In addition, PCOS is a leading symptom of infertility in women. Nevertheless, women with PCOS who become pregnant unfortunately have an increased risk of complications, such as gestational diabetes mellitus (GDM), preterm birth. Many people believe GDM disappears after childbirth, despite the fact that GDM is a warning symptom of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease. According to growing evidence, GDM complicates 40 % of PCOS pregnancies, suggesting that PCOS is a risk factor for GDM. Hence, PCOS is a lifelong disorder that can eventually lead to various long-term health complications, including chronic menstrual irregularity, infertility, endometrial hyperplasia, and endometrial cancer. Thus, it’s a scientific fact that both PCOS and GDM are significantly associated with each other. However, most studies on the risk of GDM in PCOS patients are retrospective. Therefore, there is no strong evidence whether PCOS is a risk factor for GDM or any other related factor. PCOS, a polygenic endocrinopathy, is in a true sense a set of diseases that worsen the state of the body. Reproductive and metabolic disorders associated with PCOS cause several clinical symptoms, such as irregular and painful periods, hirsutism, acanthosis nigricans, acne, psoriasis, anxiety, mood swings, patterned baldness, cardiovascular problems, type 2 diabetes, infertility, pelvic pain, low libido, low self-esteem, etc. Further studies are needed to understand the genetic and epigenetic contributions of PCOS, PCOS-related comorbidities, the role of placenta in nutrient availability, and influence of medications that may affect the long-term offspring health.
Keywords: polycystic ovary syndrome; pregnancy complications; gestational diabetes mellitus; PCOS-related comorbidities; review

In 2022, 90 years passed since the birthday of the outstanding Ukrainian scientist-anatomist, head of the Department of Normal Anatomy of the Danylo Halytsky Lviv National Medical University, Professor Mykhailo Andriyovych Netlyukh, and 50 years since the publication of his first "Latin-Ukrainian Anatomical Dictionary (International and Ukrainian anatomical nomenclature)" (Kyiv, Naukova dumka, 1972).

In our opinion, this is the anniversary date of the Ukrainian professor-anatomist Mykhailo Andriyovych Netlyukh, our dear teacher and mentor, who tirelessly, dignified, heroically defended, nurtured and developed Ukrainian names in anatomy and medicine in general, created and enriched the Ukrainian-speaking space in the years that it is difficult to call them favourable for the development of the Ukrainian language, science and culture, affirms our grateful memory, which does not fade or wither over time. We hope that the "Latin-Ukrainian Anatomical Dictionary" by M.A. Netliukh, published 50 years ago, will delight medical students, doctors, philologists and all interested people with its language richness in new editions more than once.

Introduction. Patients with acute myocardial infarction should be treated with early revascularization. Patients over 73
years have a higher risk of infarct-related cardiogenic shock, which is a leading cause of lethality. Unfortunately, little
is known about myocardial revascularization care for elderly people in Ukraine. We presented a 92-year-old lady with
an acute chest pain case report, which was not revealed by analgesics.
Important clinical findings. Coronary angiography revealed thrombotic occlusion of the distal segment of the left anterior descending artery (LAD) and floated thrombus in LAD mid-segment; stenosis of the left circumflex artery (LCx) close to the first obtuse marginal artery (OM1).
The main diagnosis. Acute myocardial infarction with ST-segment elevation of the left ventricle anterior wall (anteriorSTEMI). Calcific aortic valve disease, severe aortic valve stenosis, significant mitral and tricuspid valve regurgitation,
pulmonary hypertension. Heart failure with reduced LVEF (<40%), NYHA class III symptoms.
Intervention. The decision was to perform urgent stenting in LAD and balloon angioplasty in LCx. Successful hospital discharge was after 14 days.
Conclusions. Take-away lessons: Elderly patients with acute myocardial infarction can be successfully treated in Ukraine. Age and comorbidities are not a contraindication for early myocardial revascularization.

Застосування опіоїдів є ефективним методом лікування сильного та гострого болю, однак при їх неналежному використанні, окрім своїх потужних знеболюючих властивостей, опіоїди зумовлюють виникнення значних побічних ефектів. Початкові зміни в організмі людини, що спричинені вживанням наркотичних речовин (опіатів), виявляють у ротовій порожнині, зокрема, у слинних залозах. Наявність цілої низки невирішених питань щодо проблем структурної перебудови слинних залоз при вживанні наркотичних середників обумовило вибір тематики дослідження.