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As a result of the furfural reaction with diazonium, salts 1a-h the arylfuran-2-carbaldehydes 3a-h were synthesized. In the reaction of Wilgerodt-Kindler, arylfuran-2-carbaldehydes with sulfur and aryl piperazines was prepared 1-aryl-4-[(5-aryl-2-furyl)carbonothioyl]piperazines. The structures of target compounds 5a-l were confirmed by using 1H NMR spectroscopy and elemental analysis. The antimicrobial activity of the synthesized substances was evaluated by the value of the MIC and minimum fungicidal and bactericidal concentration. The findings exhibited that the compounds
possessed moderate antimicrobial potential. In vitro anticancer activity assessment on the full panel
The study aims to review the involvement of different dietary habits in Laotian, Cambodian, and Vietnamese populations in reducing COVID19 impact.
Materials and Methods. The methods of collection, systematization, analysis and generalization of information data have been used. The analysis of literature in scientific databases and analytical platforms by the listed keywords has been performed; all relevant references in the found sources have also been reviewed.
Results and Discussion. Coronavirus disease (COVID-19) outbreak is an ongoing pandemic caused by a highly pathogenic human coronavirus known as SARS-CoV2. Current epidemiology reported that more than 500 million cases of COVID-19 occurred in more than 180 countries worldwide. When the upper respiratory tract gets infected
by low pathogenetic HCoVs, it typically triggers a mild respiratory disease. In contrast, when the lower airways get infected by highly pathogenic HCoVs, such as SARSCoV2, acute respiratory distress syndrome (ARDS) may occur and even fatal pneumonia. Such a situation causes the need for an urgent search of effective treatment measures. A very low incidence of SARS-CoV-2 in Laos and Cambodia, as well as low mortality rate due to COVID-19 in Vietnam and Laos, are extremely interesting, especially because of their early exposure to the virus, continuing ties to China, relative poverty, and high population density. The use of several spices and aromatic herbs as natural treatments for several illnesses, including viral infections, has been reported since a long time ago. The research reviewed three integral elements of Laotian, Cambodian, and Vietnamese diets, such as special culinary spices and herbs, coconut oil, and palm oil-rich for saturated fatty acids as well as fermented shrimp paste. Environmental and population genetic
causes may be forwarded but moreover local dietary habits may have even a role in this evidence. Therefore, all these items highlight the possibility of a significant contribution of local cuisine and diet into the impact on appropriate anti-inflammatory and immune-resistant mechanisms of the human population.
Conclusions. The review on Vietnam, Cambodia, and Laos inhabitants' diet helped to suggest the dietary factors having the contributing potential of reducing the severity of SARS-CoV-2 symptoms
Keywords: COVID-19, spices and herbs, Indo-Chinese cousin, ginger, black pepper, coconut oil, fermented shrimp paste
Значення правового регулювання ДРТ в Україні на рівні закону важко переоцінити, оскільки воно впливає на безпеку, ефективність, етичні стандарти і права всіх учасників цього процесу, сприяє збалансованому підходу до інтересів кожної окремої людини та суспільства та відповідає сучасним викликам у галузі репродуктивного здоров'я та сімейного планування.
Васкуляризована композитна алотрансплантація (vascular composite allotransplantation, далі – ВКА) – це такий різновид трансплантації, коли відбувається пересадка людині (реципієнтові) тканин, зокрема обличчя, або верхніх та нижніх кінцівок. Такий вид трансплантації застосовується для лікування і реабілітації постраждалих від опіків, вибухів, нападів тварин тощо.