ABSTRACT
The aim: The objective of the research was to study the indicators of oxidative modification of proteins (OMP) and the activity of matrix metalloproteinase-9 (MMP-9) in patients with paranoid schizophrenia depending on the disease duration.
Materials and methods: 320 patients were included in the examination. 20 patients were with “Primary psychotic episode” (Comparison Group) and 300 patients were diagnosed with “Paranoid schizophrenia” (Experimental Group): 60 of them have suffered from this disease for a duration from 3 to 5 years (Subgroup I ); 60 patients have sufferedfor a period from 6 to 10 years (Subgroup II); 60 individuals – from 11 to 15 years (Subgroup III); 60 patients have suffered for a duration from 16 to 20 years (Subgroup IV); 60 patients – from 21 years and longer (Subgroup V).
Results: The presented data showed that the levels of OMP indicators in Subgroup I constituted 0.826±0.046 conventional units at a wavelength of 356 nm; 0.864±0.051 conventional units at a wavelength of 370 nm; 0.444±0.019 conventional units at a wavelength of 430 nm; 0.176±0.007 conventional units at a wavelength of 530 nm, which is 1.99; 1.6; 1.13 and 1.43 times higher than in the Comparison Group. The content of OMP products was higher by 2.24; 1.74; 1.17, and 1.43 times in Subgroup II, respectively, by 2.4; 1.80; 1.36 and 1.46 times in Subgroup III, respectively;by 2.5; 1.9; 1.4; 1.6 times in Subgroup IV, respectively; by 2.5; 2.02; 1.54; 1.7 times in Subgroup V, respectively. The conducted correlation analysis indicated a direct correlation between OMP indicators and the disease duration. The concentration of MMP-9 in the patients of the Comparison Group was equal to 892.84±87.80 pg/ml, which was 11.2% less compared to the Experimental Subgroup I, where this indicator was 992.84±67.50 pg/ml. MMP-9 constituted 1092.53±47.20 pg/ml on average in the patients of Subgroup II, which was 22.36% higher than in the Comparison Group. This indicator was 1702.84±37.60 pg/ml in Subgroup III, which was 90.7% higher than in the Comparison Group. It constituted 1492.84±47.29 pg/ml in Subgroup IV, which was 67.2% higher than in the Comparison Group;and 2037.21±57.80 pg/ml in Subgroup V, which was more than two times higher than in the Comparison Group (p<0.05). The conducted correlation analysis showed a direct relation between MMP-9 expression and the increase in OMP indicators. This relation was more significant between MMP-9 and OMP products of a neutral nature. The correlation strength between MMP-9 and OMP products of a basic nature was somewhat less significant.
Conclusions: According to the results of the conducted analysis, the examined patients hadthe signs of decompensation of reactive-adaptive biomolecular mechanisms which activated radical reactions with the subsequent accumulation of oxidation products.
Abstract
Objective: The aim: The purpose of this study was to examine the most common coping strategies in the population in quarantine settings.
Patients and methods: Materials and methods: The study used the following set of methods: a general questionnaire aimed at studying sociodemographic data, living conditions during quarantine, lifestyle during quarantine, the presence of chronic diseases and psychodiagnostic methods: assessment of distress R.Kessler, assessment of the presence of manifestations of anxiety-depressive response GAD-7, depression self-assessment scale PHQ-9, stress-overcoming behavior strategies (E. Heim), as well as mathematical methods for processing the obtained data.
Results: Results: Social and psychological characteristics of the examined were investigated, where coping strategies during the quarantine period play a role in the adaptation process and the state of the psychoemotional sphere. Non-adaptive cognitive coping was characterized by the presence of direct strong correlations with high levels of distress and high rates of anxiety and depression.
Conclusion: Conclusions: Quarantine restrictions are risk factors for mental health deterioration. In these settings, the interaction of stress factors with anti-stress protection components is important, among which coping strategies play a leading role.
UDC 378.147:070-051]:004.8
In the era of intelligent communication, artificial intelligence technology is widely applied across various stages of news production, marking the advent of the era where news is collaboratively produced by humans and machines. Consequently, there has been a corresponding shift in the demand for talent in the media industry. The goal of the article is to investigate the dynamic intersection of artificial intelligence and intelligent communication technologies in training future journalists. The emergence of new technologies is prompting journalism education to adapt to new demands and undergo reforms. Traditional journalism education is no longer able to meet these new talent requirements, necessitating transformations in journalism education. Building upon the analysis of the impact of intelligent communication on news production, this article reviews past reforms in journalism education amid technological innovations and proposes an educational breakthrough focused on cultivating “H” talents in the era of intelligent communication. Therefore, journalism education in the era of intelligent communication urgently needs reforms.
УДК: 378:070.42
The article deals with the issue of technology application in special education and the development of artificial intelligence technology or its presentation in journalism education. With the rapid iterative development of artificial intelligence (AI) technology, nations worldwide are elevating it to a national strategy, guiding industrial development, technological iteration, and talent cultivation. This problem especially concerns future journalists. Relevance of the article involves a holistic study of the significance of media production models in the era of artificial intelligence. This study aims to explore a competency framework for undergraduate talents in the field of news and communication from the perspective of artificial intelligence, addressing questions related to the changing landscape of media technologies and their impact on talent development. Through this research, an attempt will be made to devise a talent competency framework that aligns with global industry development trends, contributing to talent cultivation that meets the needs of both the nation and enterprises. The emergence of intelligent technologies as writing robots poses new requirements for journalists in the field of news and communication. Higher education institutions face challenges in developing news and communication talents. Whether itʼs the emergence of new communication platforms or the transformation of communication models, future journalists are required to make adjustments and adapt in terms of their abilities and thinking. Correspondingly, reforms and innovations in journalism education are needed. Against this backdrop, the reform and development of journalism education in China require continuous attention and exploration. From the perspective of artificial intelligence, the dynamic convergence of media technologies has been a frontier topic in the field of journalism and communication studies, opening up new avenues for journalism education.
UDC 611.132.2:616.12-005.4]-055.2-073.756.4
Angiographic examination of the coronary arteries – coronary angiography allows for intravital evaluation of the coronary arteries. Structural lesions of the coronary arteries are a prerequisite for developing coronary heart disease, the most common form of cardiovascular disease among women. The work aimed to carry out a morphometric analysis of coronary artery valves in women in normal conditions and under coronary artery damage, with an assessment of the relationship between age and anthropometric indicators. Angiographic images of the coronary arteries of 56 normal women and those with structural lesions of the coronary arteries served as materials and methods. Used methods: coronary angiography, mathematical and statistical calculations. In women with lesions of the coronary arteries, the height of the left coronary artery ostia (4.78±1.16 mm) exceeded the height of the right coronary artery ostia (3.94±0.98 mm) (p=0.003). Similar differences were found in women without lesions of the coronary arteries, in particular, the height of the left coronary artery ostia was 5.96±0.91 mm, the height of the right coronary artery ostia was 4.58±1.10 mm (p<0.0001). The height of the ostia of the left (p=0.0001) and right (p=0.027) coronary arteries prevailed in healthy patients, compared to the group with coronary artery lesions. According to the analysis of the combined effect of several factors on the height of the coronary artery valves, it was established that with increasing age, height (r=-0.35, р=0.047) and body surface area (r=-0.37, р=0.035) decreased. Height was directly correlated with body weight (r=+0.36, p=0.043). According to the results of the paired correlation, a direct correlation of average strength between height and body weight (r=+0.49, p=0.014) and body surface area (r=+0.63, p=0.001) was proved. Thus, with the help of the angiographic method of research, various relationships between the height of the coronary artery ostia and the age-anthropometric parameters in women with coronary artery lesions and under normal conditions were established.