Metabolic physiology plays a key role in maintaining our health and resilience. Metabolic disorders can lead to serious illnesses, including obesity. The pathogenesis of the new long COVID syndrome in individuals with long-term recovery after SARS-Co-2 infection is still incomplete. Thus there is growing attention in the study of adipose tissue activities, especially brown adipose tissue (BAT) and associated resilience which plays a crucial role in diferent types of obesity as potential targets for pharmacologic and nutritional interventions in the context of obesity and long COVID. The number of studies examining mechanisms underlying BAT has grown rapidly in the last 10 years despite of role of BAT in individuals with COVID-19 and long COVID is modest. Therefore, this review aims to sum up data examining BAT activities, its resilience in health, obesity, and the possible link to long COVID. The search was conducted on studies published in English mostly between 2004 and 2022 in adult humans and animal models. Database searches were conducted using PubMed, Scopus, and Google Scholar for key terms including adipose tissue, BAT, adipokines, obesity, VPF/VEGF, and pathogenesis. From the initial search through the database were identifed relevant articles that met inclusion and exclusion criteria and our data regarding adipose tissues were presented in this review. It will discuss adiposity tissue activities. Current literature suggests that there are BAT integral efects to whitening and browning fat phenomena which refect the homeostatic metabolic adaptive ability for environmental demand or survival/adaptive mechanisms. We also review neural and vascular impacts in BAT that play a role in resilience and obesity. Finally, we discuss the role of BAT in the context of long COVID in basic research and clinical research.

On October 14, 2022, the 6ᵗʰ International Symposium “SMART LION” (Science Medicine Arts Research Translational Lviv International Opportunity Network) was held in Lviv with the support from Danylo Halytsky Lviv National Medical University, the Medical Commission of  the Shevchenko Scientific Society, Lviv City Council and Lviv Conference Bureau. It was no coincidence that the time of the conference coincided with the Day of Defenders of Ukraine,  which include military medical professionals and scientists who equip them with knowledge  and skills enabling them to save lives on the battlefield.  The purpose of the symposium was to analyze the new experience of medical professionals  and volunteers of Ukraine and its allies, which they acquired during russia's war against  Ukraine, develop new methods in medical education, and establish close cooperation between military medical professionals, volunteers, and scientists.  The scientific event was held online via ZOOM. It was also streamed on the Facebook page of the journal “Proceedings of the Shevchenko Scientific Society. Medical Sciences”. The event  featured more than 20 speeches by international and domestic scientists and highly qualified specialists. Subsequently, they will serve as a scientific and practical foundation for the development of both military and general medicine. Discussions during the conference clearly showed the need for systemic changes in medical education, supplementing educational programs taking into account the vast experience of military medical professionals, and improving teaching methods. At the end of the symposium, organizers expressed confidence that most of the deliverables  and ideas highlighted during the conference will be successfully implemented. We sincerely thank all defenders and allies of Ukraine, volunteers and medical professionals who save people's lives, sometimes pulling them out of the death grip. With hope for and belief in a bright future, with faith in an upcoming victory and plans to meet again live in Lviv at SMART LION 2023

Intravascular ultrasound (IVUS) is a modern method of visualizing the coronary arteries from the lumenal surface of the vessel [1]. The cross-sections of the intracoronary images make possible the measuring of the coronary artery size and assessing the structure of the vessel [2], which is extremely important in the context of cardiovascular diseases.The uniqueness of ultrasound is based on the fact that diferent layers of the coronary artery wall re"ect ultrasound waves diferently, anatomically preconditioned. Therefore, understanding the anatomical aspect of the vessel structure is the key to interpreting the intracoronary images. Even though IVUS is widely used in the leading clinics [3], for the majority, it is a less accessible procedure [4]. Unfortunately, IVUS remains an innovative procedure for much medical sta! and requires further explanation of coronary vessel morphology. The coronary artery size is variable and impacts the coronary stent implantation and optimization of the results of coronary revascularization [5, 6]. To our knowledge, there is no data on the size of coronary arteries ostia among the Ukrainian population using IVUS

Coronavirus Disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus, which is a contagious respiratory virus causing atypical pneumonia COVID-19 in adult and children with Severe Acute Respiratory Syndrome (SARS). The SARS-CoV-2 genome also encodes four structural (S, E, M and N) and up to six accessory (3a, 6, 7a, 7b, 8, and 9b) proteins. The spike protein (S) is further divided into 2 subunits, S1 and S2 that mediate host cell attachment and invasion. Anti-SARS-CoV-2 Monoclonal Antibodies (mAbs) that target the spike protein have been shown to yield clinical benefits in treating SARS-CoV-2 infection. This article represents a clinical case of a 59-year-old man with Coronavirus Disease (COVID-19) and intracerebral haemorrhage, who was treated with the use of monoclonal antibodies bamlanivimab and etesevimab. Equally, it presents a review of these drugs’ application for COVID-19 treatment in adults
and children

To date, various manifestations of allergic reactions and diseases are registered in 15-35% of the population according to the World Health Organization, and in recent years there has been a constant tendency to increase [1]. The first sign of allergic pathology in children, as a rule, is a food allergy, which is mainly manifested by atopic dermatitis. According to official statistics, the rate of atopic dermatitis in Ukraine is known to range from 3 to 10 per 1000 children [2]. However, the results obtained in some regions of our country according to studies under the standardized international program ISAAC (International Study of Asthma and Allergies in Childhood), exceed the above figures by 5-10 times [3]. This situation can be explained by the presence of terminological differences in the interpretation of atopic dermatitis in children, different methodological approaches to statistical research, clinical and age-related polymorphism of the disease. The development of atopic march can begin with a food allergy, so all efforts of physicians should be directed to prevent the transformation of skin forms into respiratory ones and provide the patient and his/her parents with a full quality of life [4,5]. The “School of Atopy” operates under the auspices of the MNPE “Lviv City Children’s Clinical Hospital” and the Lviv City Children’s Allergological Center, where a model of a multidisciplinary approach to the management of patients with food allergies according to European standards was reproduced. Every patient treated for food allergies goes from diagnosis to treatment. Of course, great emphasis is placed on preventing and predicting the development of atopic march in children and improving the quality of life of patients and their parents.