Abstract: Our study aimed to evaluate the effect of whole body vibration (WBV) treatment as an non-pharmacological method of treatment for early osteopenia in ovariectomized female rats. In total, 48 female Wistar rats were assigned to two groups: sham-operated control (SHAM, n = 12) and ovariectomized (n = 36). Four weeks after ovariectomy, the animals were divided into three experimental groups (n = 12 each): ovariectomized (OVX), ovariectomized subjected to whole body vibration with acceleration level of 0.3 g (OVX + WBV), or ovariectomized subjected to i.m. injection of Zoledronic acid at a dose of 0.025 mg/kg (OVX + ZOL). After the 8th and 16th week of treatment n = 6 rats from each group were euthanized and isolated femora were subjected to histological examination of trabecular bone and analysis of the expression of collagen 1 (Col1), osteoprotegerin (OPG), and receptor activator of nuclear factor kappa-B ligand (RANKL) involved in bone turnover. The obtained results indicated that widespread vibration therapy can provide negative outcomes such as deterioration of trabecular bone histomorphometry.
УДК: 616.697-008.8-06:616.72-002-092:612.015.11]-07
Background. Male infertility is one of the most serious medical and social problems. Idiopathic infertility accounts for about 30 % of cases of infertile men. Rheumatoid arthritis is associated with a decreased fertility potential. The aim of the present work was to determine the lipid peroxidation level and the activity of antioxidant enzymes such as glutathione peroxidase and glutathione reductase in seminal plasma and blood plasma of infertile men with idiopathic infertility and concomitant autoimmune joint pathology (rheumatoid arthritis).
Materials and Methods. 45 infertile men aged 22–48 were examined. They were divided into 2 groups: first group – 23 somatically healthy patients with idiopathic infertility; second group – 22 infertile men with rheumatoid arthritis. The control group consisted of 27 males with normal semen profile according to the WHO criteria and confirmed parenthood. The concentration of thiobarbituric acid reactive substance and activity of antioxidant enzymes were measured in the blood and seminal plasma.
Results. When analyzing the seminal fluid, we found that the TBARS content was 4-fold greater in infertile men with autoimmune pathology compared to fertile men (p <0.001), whereas, in patients with idiopathic infertility its level was within the normal range. The activation of lipid peroxidation in infertile men with idiopathic infertility and in combination with rheumatoid arthritis was accompanied by a statistically significant decrease in the activity of enzymes of glutathione antioxidant system. It should be noted that more pronounced disorders of lipid peroxidation and antioxidant enzymes activity were found in seminal plasma compared to blood plasma.
Conclusions. (1) An increased lipid peroxidation was observed in seminal and blood plasma of infertile men in combination with rheumatoid arthritis compared to normospermic men, whereas no differences were observed between men with idiopathic infertility and fertile men; (2) An impaired antioxidant status was observed in seminal and blood plasma of both men with idiopathic infertility and infertile men in combination with rheumatoid arthritis compared to normospermic men; (3) infertile men in combination with rheumatoid arthritis showed a significantly higher lipid peroxidation levels compared to men with idiopathic infertility, whereas no differences were observed in GPx and GR activity between groups.
In 2022, 90 years passed since the birthday of the outstanding Ukrainian scientist-anatomist, head of the Department of Normal Anatomy of the Danylo Halytsky Lviv National Medical University, Professor Mykhailo Andriyovych Netlyukh, and 50 years since the publication of his first "Latin-Ukrainian Anatomical Dictionary (International and Ukrainian anatomical nomenclature)" (Kyiv, Naukova dumka, 1972).
In our opinion, this is the anniversary date of the Ukrainian professor-anatomist Mykhailo Andriyovych Netlyukh, our dear teacher and mentor, who tirelessly, dignified, heroically defended, nurtured and developed Ukrainian names in anatomy and medicine in general, created and enriched the Ukrainian-speaking space in the years that it is difficult to call them favourable for the development of the Ukrainian language, science and culture, affirms our grateful memory, which does not fade or wither over time. We hope that the "Latin-Ukrainian Anatomical Dictionary" by M.A. Netliukh, published 50 years ago, will delight medical students, doctors, philologists and all interested people with its language richness in new editions more than once.
After three years of the outbreak of Coronavirus Disease 2019 (COVID-19) pandemic, main tasks as to treatment and vaccination are still pending their solution. Today, it is known that SARS-CoV 2 coronaviruses are intracellular viral infections having an inevitable negative impact on all cells of the human body, including the blood cells. It is established that COVID-19 patients can be classified into mild, moderate, and severe. Modern literature does not describe ultrastructural changes of circulatory blood cells in patients with moderate course of this disease.
Introduction. Patients with acute myocardial infarction should be treated with early revascularization. Patients over 73
years have a higher risk of infarct-related cardiogenic shock, which is a leading cause of lethality. Unfortunately, little
is known about myocardial revascularization care for elderly people in Ukraine. We presented a 92-year-old lady with
an acute chest pain case report, which was not revealed by analgesics.
Important clinical findings. Coronary angiography revealed thrombotic occlusion of the distal segment of the left anterior descending artery (LAD) and floated thrombus in LAD mid-segment; stenosis of the left circumflex artery (LCx) close to the first obtuse marginal artery (OM1).
The main diagnosis. Acute myocardial infarction with ST-segment elevation of the left ventricle anterior wall (anteriorSTEMI). Calcific aortic valve disease, severe aortic valve stenosis, significant mitral and tricuspid valve regurgitation,
pulmonary hypertension. Heart failure with reduced LVEF (<40%), NYHA class III symptoms.
Intervention. The decision was to perform urgent stenting in LAD and balloon angioplasty in LCx. Successful hospital discharge was after 14 days.
Conclusions. Take-away lessons: Elderly patients with acute myocardial infarction can be successfully treated in Ukraine. Age and comorbidities are not a contraindication for early myocardial revascularization.