Abstracts

Background. In previous studies, we have shown that electrokinetic index of buccal epithelium (EKI) correlated with some functional and metabolic parameters. Subsequent studies have shown that сhanges in EKI correlated with changes in some parameters of EEG, HRV, hemodynamics, metabolism, immunity and fecal microbiocenosis. Further research in this direction was continued on a significantly increased contingent of patients and with the involvement of new methods and factors of influence. This message starts the presentation of the obtained results. Material and methods. Under a observations were 44 men (49±15 years) and 30 women (51±13 years) without clinical diagnosis or with chronic pyelonephritis in the phase of remission (23 men). We registered caused by the various therapeutic factors changes in EKI, state of the vegetative and hormonal regulation as well as immunity and metabolism, then calculated relationships between changes. Results. In 49 patients the changes in EKI were in the range of ±2,5%, in 19 people EKI increased by more than 2,5% (M±SD=+4,0±1,6%), while in 9 people decreased by more than 2,5% (-4,2±1,7%). The canonical correlation between changes in EKI, on the one hand, and HRV and immunity parameters, on the other, is moderate: R=0,478; p=0,023. The method of discriminant analysis revealed 10 immune and 6 HRV parameters as well as triglycerides and cholesterol, whose changes are characteristic of multidirectional changes in EKI. Conclusion. Electrokinetic index of buccal epithelium responds to therapeutic factors in different directions, accompanied by characteristic changes in a number of parameters of HRV, immunity and metabolism.

Keywords: Electrokinetic index, HRV, hormones, immunity, metabolism, relationships.

Abstract. Spinal dysraphism (SD) or spina bifida (SB) is a congenital deformity that results from embryonic neural tube closure failure during fetal devel- opment. This evidence-based position paper represents the official position of the European Union through the UEMS PRM Section. This paper aims to evaluate the role of the physical and rehabilitation medicine (prM) physician and prM practice for children and adults with spinal dys- raphism. a systematic literature review and a consensus procedure involved all European countries delegates represented in the uEMs prM sec- tion through a delphi process. the systematic literature review is reported together with thirty-two recommendations resulting from the delphi procedure. The professional role of the PRM physician requires specific expertise in the treatment of patients with SD to plan, lead and monitor the rehabilitation process in an interdisciplinary setting and to participate in the assessment of the needs of these patients in the transitional phase from childhood to adulthood, with particular attention to the activity limitation and participation restriction.

Key words: spinal dysraphism; rehabilitation; physical and rehabilitation medicine; Guideline adherence; consensus.

Background. Earlier, we found a close canonical correlation between parameters of gas discharge visualization (GDV) and principal neuroendocrine factors of adaptation. The purpose of this study is to elucidate the relationship between GDV and immunity parameters. Material and research methods. We observed twice 10 women and 10 men aged 33-76 years without clinical diagnose. In the morning in basal conditions at first registered kirlianogram by the method of GDV by the device “GDV Chamber” (“Biotechprogress”, SPb, RF). For further analysis the following parameters were selected: Area, Shape Coefficient as ratio Square Length of outward contour gas discharge image to its Area as well as Entropy of contour in Right, Frontal and Left projections registered both with and without polyethylene filter. Estimated also Energy and Asymmetry of virtual Chakras. Then registered routine parameters of cellular and humoral Immunity. Results processed by method of canonical analysis, using the software package “Statistica 5.5”. Results. According to the value of the canonical correlation coefficient R with GDV parameters, the immunity parameters are arranged in the following order: IgA (0,716; p=0,005), CD8+CD3+ Tc-lymphocytes (0,646; p=0,004), IgG (0,645; p=0,002), IgM (0,622; p=0,0001), “active” T-lymphocytes (0,572; p=0,007), CD4+CD3+ Th-lymphocytes (0,566; p=0,003), CIC (0,491; p=0,018), 0- lymphocytes (0,457; p=0,036), CD16+ NK-lymphocytes (0,396; p=0,043), CD22+ B- lymphocytes (0,439; p=0,105). The integral canonical correlation between the parameters of GDV and Immunity was very strong (R=0,994; p<10-4). Conclusion. Between parameters of Immunity and parameters of GDV exist strong canonical correlation suggesting relevance and informativenes this method. Keywords: Gas Discharge Visualization, Cellular and Humoral Immunity, Relationships. 

Introduction Coronavirus disease 2019 (COVID-19) is characterized by impact on different systems of human body. Recently, several anti-COVID vaccines have been developed. Material and methods In our study, we included two groups of males: GROUP1, anti-COVID vaccinated males, n = 46, and GROUP2, n = 43, non-vaccinated males, who all fell ill with the Coronavirus infection. A level of semen DNA fragmentation was characterized by Sperm DNA Fragmentation Index (SDFI) that was calculated before infection and compared with data at every month after laboratory recovery. The Mann–Whitney test was used to establish differences between parameters, with p <0.05 considered significant. Results Compared with the pre-COVID baseline we registered significant increasing of SDFI in each group of participants: 35.3 ±4.7% vs 18.6 ±5.8% in GROUP1, p = 0.0009, and 41.8 ±5.6% vs 19.2 ±6.1% in GROUP2, p = 0.0006. At the 2nd month after recovery SDFI in GROUP1 and GROUP2 continued to grow and reached its peak to 40.6 ±6.4% and 49.7 ±7.2% respectively. Thereafter SDF indexes in both Groups started to decrease, normalizing at the 7th month after COVID-19 recovery in GROUP1 and at the 9th month in GROUP2. Conclusions COVID-19 causes a gradual increase in semen DNA fragmentation, which peaks at the 2nd month after recovery and is more pronounced in unvaccinated men. Normalization of SDFI occurs no earlier than at the 7th month in vaccinated and at the 9th month in non-vaccinated men.

Abstract

A dangerous combination of two diseases that have reached pandemic proportions, COVID-19 and type 2 diabetes, have unique features of the comorbid course. Intense inflammation, hypercoagulation, dysglycemia, and immune and renal dysfunction are underlying processes in the pathogenesis of the combination of these diseases. Our study aimed to compare groups of hospitalized patients with moderate to severe coronavirus disease with and without diabetes, paying particular attention to renal function and examining the relationships between markers of renal dysfunction, inflammation, and thrombosis in these patient groups. In total, 79 patients aged 24 to 73 with moderate to severe coronavirus disease were examined. Patients were divided into 2 groups: 1st – without diabetes; 2nd – with diabetes. The clinical picture, laboratory results (additionally determined cystatin C level) and instrumental studies were compared. Correlation analysis was conducted in groups. The group of patients with type 2 diabetes mellitus had significantly lower oxygen saturation upon admission to the hospital. A significantly higher concentration of glucose in blood serum (11.3 (8.1; 16.5) mmol/l 5.2 (4.4; 6.6) mmol/l, P<0.01) and a lower creatinine level (106.0 (87.3; 123.0) mcmol/l vs. 129.5 (104.8; 167.3) mcmol/l, P<0.05) were observed in the 2nd group while there were no differences in urea and cystatin C levels. By means of correlation matrices, it was established that inflammation, hypercoagulation, dysglycemia, and impaired kidney function are underlying causes of the coronavirus disease pathogenesis in group 1 of patients. At the same time, inflammation and hypercoagulation are the causes in the group of patients with a combined course of type 2 diabetes mellitus. Although the combined course of coronavirus disease and type 2 diabetes mellitus is prognostically more severe, we found a significantly lower creatinine level in the group of patients with type 2 diabetes.