Dental caries remains the most common disease of the oral cavity. The analysis of literary sources proves that the incidence of dental caries in children burdened with somatic pathology is significantly higher than in healthy children. Domestic studies of recent years testify to the growth of pathology of the musculoskeletal system and connective tissue in children. Therefore, the goal of our study was to develop a treatment-prophylactic complex and clinical evaluation of its effectiveness in this pathology. For this purpose, 60 children aged 5-6 years were under observation,
comprised of two main and two control groups. The preventive complex included 3 stages: hygienic education and
upbringing of children and their parents, which was carried out in preschools at "Dental Health Lessons"; professional oral hygiene (performed 2 times a year, and in children with unsatisfactory oral hygiene 2-3 times a year); a differentiated approach to the selection of exogenous caries prevention means (deep fluoridation of all teeth was carried out twice a year, "Tooth Mouth" was used at home in courses of 10 days; children with unsatisfactory oral hygiene and with UCTD were carried out 3-4 times a year). In cooperation with a pediatrician, the children's nutrition
was corrected. The children of the control groups were given preventive measures and sanitation of the oral cavity
following local protocols for the provision of medical care. Indicators of caries intensity, increase in intensity, reduction of increase in caries intensity evaluated the effectiveness of preventive measures. Therefore, after two years of using the preventive complex, the indicators of the reduction of the increase in caries intensity increased, which indicates the effectiveness of the use of this complex in children with MSS pathology and MSS pathology against the background of UCTD, regarding the course of the carious process by creating favorable conditions for enamel maturation.
Key words: caries, temporary teeth, pathology of the musculoskeletal system, prevention.

Herein, a method for the coke dry quenching (CDQ) process has been proposed and its optimization has been carried out, which will minimize the disadvantages of this process. This optimization was carried out to develop a technology for uniform coke distribution in the quenching chamber. A model of the real charging device for quenching coke from the Ukrainian enterprise PrJSC “Avdiivka Coke” was developed, and several shortcomings of its operation were shown. It is proposed to use a coke distributor in the form of a bell and a modified bell (specially shaped holes). Graphic mathematical models of the operation of these two devices were developed, and the efficiency of the last of the developed distributors was shown.

Phenolformaldehyde resins were obtained by polycondensation of concentrated phenols with formaldehyde in the presence of hydrochloric acid. Concentration of phenols is carried out by treating the phenolic fraction of coal tar with an aqueous solution of sodium hydroxide followed by neutralization of water-soluble phenolates with hydrochloric acid. The kinetic dependences of resin yield and softening temperature on the duration of the process at 333, 353, and 373 K were obtained. The order of the reaction was determined and the effective activation energy of this process was determined by a graphical method. In the interval 333-373 K for polycondensation reactions, the equation of the dependence of the resin yield on the temperature and duration of the process was obtained.

In the present work, we presented an efficient synthesis and anticancer activity evaluation of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. We have shown that the proposed synthetic protocols provided the possibility to design triazolothiadiazoles diversity with a considerable chemical novelty. The structures of target substances were confirmed by using 1H NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds were selected by the National Cancer Institute Developmental Therapeutic Program for the in vitro cell line screening. Among all the substances tested, three compounds exhibited significant cytotoxic activity.

The synthesis, anticancer and antimicrobial properties of novel N-aryl-2-(5-aryltetrazol-2-yl)acetamides were discussed. Novel N-aryl-2H-tetrazoles were synthesized and modified in order to obtain the compounds with a satisfactory pharmacological profile. The structures of target substances were confirmed by using 1 H spectroscopy, mass spectrometry and elemental analysis. Anticancer activity screening was carried out within the framework of Developmental Therapeutic Program of the National Cancer Institute's (DTP, NCI, Bethesda, Maryland, USA).
The compounds with significant levels of anticancer activities have been found that can be used for further optimization. The antimicrobial activity of the synthesized substances was evaluated by the value of the MIC and minimum fungicidal and bactericidal concentration. The findings exhibited that the compounds possessed moderate antimicrobial potential