Abstract.1 New 4-aryl-3-(morpholin-4-yl)-2-arylimino-2,3-dihydrothiazole derivatives 1.1-1.16 were obtained using the Hantzsch reaction by condensation of N-(morpholin-4-yl)-N'-arylthioureas with the corresponding α-bromoacetophenones in alcohols. Synthesized hydrobromides 1.1-1.8 were formed as crystalline precipitates during the boiling of the reaction mixture. Bases 1.9-1.16 were obtained by neutralizing the corresponding hydrobromides with NH4OH solution. It has been proposed a possible mechanism of the reaction that is based on the study of the structure of the synthesized compounds. The structures of the synthesized compounds were confirmed by 1H NMR spectroscopy with its special techniques (NOESY and ROESY experiments). It has been shown the formation of the isomer 4-(4'-chlorophenyl)-3-(morpholin-4-yl)-2-(4'-chlorophenylamino)-2.3-dihydrothiazole on the basis of compound 1.14. Pharmacological screening of synthesized derivatives of 4-aryl-2-arylimino-2,3-dihydrothiazole compounds revealed the analgesic effect in the model of visceral pain caused by the introduction of acetic acid to white mice. The anti-inflammatory effect of the synthesized compounds was evaluated in vivo by reducing limb edema in rats with carrageenan-induced inflammation. Thus, the synthesized compounds have analgesic and anti-inflammatory activity. 

The aim:The aim of the article is to empirically study the features of tolerance to uncertainty in late adulthood in groups of working and retired people and test the hypothesis of the impact of communication in social networks as one of the possible ways to increase mental well-being in this category of people.
Materials and methods: The study was conducted in 2021 in the Lviv region of Ukraine. Forty people aged 60 - 75 were interviewed. Among them there were 20 people with a 40-hour working week and 20 retired people. To assess the level of tolerance to uncertainty, the tolerance scale by D. L. McLain (modified by E.M. Osin) has been used; to determine the level of dependence on social networks, the Bergen Facebook Addiction Scale (having tested 20 people who are retired in the age group 60-75 ) has been applied.
Results: The results of the study showed that: (1) the level of the integrated indicator of “tolerance to uncertainty” is higher among people who work than among those who are retired; (2) people of the age group of 60-75 who work have higher values in all components of the uncertainty tolerance indicator; (3) there is a high interdependence between the expansion of the communication environment through communication in social networks and the level of tolerance to uncertainty among retired people in the age group of 60-75.
Conclusions: People in the age group of 60-75 who work have a greater potential for successful aging due to the higher value of the components of tolerance to uncertainty and their connection to personality traits on which mental well-being depends. The increase in the level of mental well-being of retired people of late adulthood can be achieved through influencing the uncertainty factor: either by employing these people or by actively involving them in communication in social networks. 

The aim: The purpose of the study is to evaluate the clinical and laboratory features of COVID-19 pneumonia course, the diagnostic significance of laboratory methods for detecting the SARS-CoV-2 virus based on a retrospective analysis.
Materials and methods: We studied the case histories of 96 patients who were treated at the Municipal Non-Profit Enterprise “Lviv Clinical Emergency Care Hospital” for the period from 01/07/2020 to 31/07/2020 with a diagnosis of pneumonia, which corresponded to 5 points on the CO -RADS scale. We analyzed the clinical and laboratory signs of COVID-19 pneumonia depending on the results of the Quantitative Reverse Transcription Polymerase Chain Reaction (RT-qPCR) tests to the SARS-CoV-2 infection (positive result of RT-qPCR was observed in the first group and negative – in the second group).
Results: In both groups, no clinical differences in the course of the disease were found. The most common symptoms of coronavirus pneumonia were found with the same frequency in both patients with a laboratory-confirmed diagnosis and without it. A positive PCR test in nasopharyngeal and oropharyngeal swabs was more often detected during testing up to 10 days, in patients over 60 years of age and in severe COVID-19.
Conclusions: The COVID-19 pneumonia diagnosis should be based on a combination of clinical, laboratory, and radiological signs of this disease. A negative PCR test result does not exclude the diagnosis of coronavirus disease. The test results are influenced by the timing of the sampling, the severity of the disease and the age of the patients

Introduction: Biological markers of inflammation are among the main tools for predicting the risk of developing postoperative infectious complications at the preclinical stage. One of these biomarkers is the neutrophil-lymphocyte ratio (NLR), but the insufficient number of studies does not allow judging its value as a marker of infectious complications in colorectal surgery.
Aim: Aim of the study to determine the predictive value of the neutrophil-leukocyte ratio as a predictor of infectious
complications after colon surgery.
Methods: From September 2018 to December 2021, 234 patients were enrolled in the study after colon surgery. The frequency of infectious complications, the differences in the levels of NLR in patients with and without infectious complications were determined.
Results: One hundred and thirty-seven patients met the criteria of NLR-low, and 97 patients were categorized as NLR-high. The NLR status was significantly correlated with T-stage, perineural invasion, and increased likelihood of complications. Univariate analysis indicated that both low albumin and meeting the criteria for the NLR-high group correlated with an increased occurrence of complications. Multivariate analysis identified NLR-high and low albumin levels as independent predictors for complications.
Conclusion: The neutrophil-lymphocyte ratio is a reliable predictor in predicting the risk of developing infectious complications in colorectal surgery. In addition, low values of this biomarker are a significant criterion for a safe discharge of patients from hospital. The prevalence and availability of this test makes it easily reproducible in clinical practice