Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus, which affects both children and adults. Although most cases of COVID-19 in children have a mild course, sometimes the disease is severe. Multisystem inflammatory syndrome in children (MIS-C) is a rare complication of COVID-19, characterized by pronounced cardiovascular, gastrointestinal, and skin-mucosal signs and symptoms that, in particular, may meet the criteria for atypical or typical Kawasaki disease (KD). This article represents a clinical case of a 13-year-old boy with an atypical course of SARS-CoV-2-
Induced Kawasaki-Like Multisystem Hyperinflammatory Syndrome, who was treated with intravenous immunoglobulin, corticosteroids, and aspirin. Equally, it presents a thorough description of carrying out a differential diagnosis between MIS-C and Kawasaki disease and a review of the application of drugs needed for MIS-C treatment, the main goal of which is to ensure the best protection against CA aneurysms and avoid long-term sequelae.