UDC 616.12-008.331.1:616.379-008.64:616.988:578.834

The aim of this study was to assess the level of nitric oxide production and arginase activity in patients with arterial hypertension and type II diabetes mellitus during infection with SARS-CoV-2. The study groupsvincluded patients with arterial hypertension, patients with arterial hypertension combined with a severe course of COVID-19 and patients who, in addition to arterial hypertension and COVID-19, were suffering from type II diabetes mellitus. The volunteers without any clinical signs of diseases and normal blood pressure formed the control group. It has been established that arterial hypertension, combined with COVID-19 occurs along with reduced L-arginine, nitric oxide, superoxide dismutase activity and increased arginase activity. At the same time, the presence of arterial hypertension in patients with diabetes and coronavirus disease is accom-panied by a decline in the content of L-arginine and arginase activity. Our study’s results may help scientists find new pharmacological targets in the future treatment of coronavirus disease and comorbid disorders.

This book is aimed at studying the fundamentals of biochemical processes in the human body under normal conditions and in pathology. It can be used by students of medical universities and colleges, as well as students in biological specialties. However, the particular feature of this book is that it aligns with the curriculum for the study of biological chemistry in medical institutions in Ukraine.

The first part of the book consists of 16 chapters. The first chapter introduces the objectives of biochemistry as a science and briefly describes its history and research methods. Chapters 2-3 focus on enzymology, providing essential information about enzymes. Chapter 4 deals with vitamins, with particular emphasis on the biological functions of water-soluble and fat-soluble vitamins and vitamin-like substances. Chapters 5-6 discuss the production and utilization of energy in various metabolic pathways of carbohydrates, lipids, and amino acids. Chapters 7-10 describe the main carbohydrate metabolism pathways under normal and pathological conditions. Chapters 11-13 cover lipid metabolism, while chapters 14-16 delve into amino acid metabolism. The continuation of the book will be available in Part 2 soon