Summary

Among patients with acute abdominal pathology who were hospitalized in surgical hospitals, about 5% are patients with acute pancreatitis. Moreover, in recent decades there has been a multiple increase in the incidence rate. According to many studies in industrialized countries, the incidence of acute pancreatitis is in the range of 200 to 800 new cases of acute pancreatitis per 1 million population per year. According to many researchers, one of the main factors causing severe acute pancreatitis is the invasion of gram-negative bacteria from the colon, through pathological bacterial translocation. This mechanism may play a major role in the development of septic complications - "death begins in the colon, which in acute abdominal pathology turns into an undrained abscess." The article presents and analyzes the results of ultramicroscopic study of changes in the structure of the mucous membrane of the colon in patients with destructive forms of acute pancreatitis. 75 microphotographs were analyzed. It was found that in acute pancreatitis, the main foci of destruction were localized in the surface layers of the mucous membrane of the colon. The changes found at the ultrastructural level are considered to be a morphological manifestation of pathological bacterial translocation in the studied pathology.

Keywords: pancreas, colon, pathological bacterial translocation