Purpose.To analyse the changes in local immunity in the oral fluid of servicemen of the Armed Forces of Ukraine with chronic catarrhal gingivitis depending on their psycho-emotional state.

Material and methods. The study of local oral immunity in oral fluid was conducted in 22 military patients of the Armed Forces of Ukraine with chronic catarrhal gingivitis (main group), in 11 patients of civilian specialties with chronic catarrhal gingivitis (comparison group), and in 16 dentally healthy individuals (control group). Additionally, military patients in the main group were divided into 4 subgroups depending on their psychoemotional state. The determina- tion of sIgA in the oral fluid was performed by the method of Mancini et al. The photoelectrocolorimetric method was used to measure lysozyme activity in the oral fluids of patients. The content of cortisol in the oral fluid of patients in the study groups was determined by a competitive enzyme-linked immunosorbent assay.

Results. As a result of the laboratory studies, it was found that in patients with chronic catarrhal gingivitis, military personnel of the Armed Forces of Ukraine had a 1.2-fold decrease in the content of sIgA in the oral fluid (p<0.01) and lysozyme activity (p<0.05), against the background of an increase in cortisol levels by 61.18 % (p<0.01) compared to the data in the comparison group.

Conclusion. Thus, summing up the data of laboratory studies, it can be stated that patients of the main group (mili- tary personnel of the Armed Forces of Ukraine) with chronic catarrhal gingivitis have a more pronounced weakening of local oral immunity, which is manifested by a decrease in sIgA levels and lysozyme activity, compared with similar data in the comparison group (patients of civilian professions) with chronic catarrhal gingivitis. At the same time, the imbalance of immunological parameters deepened with the deterioration of the psychoemotional state of patients in the main group, which was confirmed by an increase in the level of cortisol in the oral fluid.

Keywords: chronic catarrhal gingivitis, military personnel, psycho-emotional state, local oral immunity, oral fluid

This article presents the data on the effectiveness of the treatment complex we developed on the activity of bone remodelling markers in the oral fluid during the treatment of generalized periodontitis,depending on the blood group.

Objective of the research was to identify dominant morphometric features of periodontal phenotype and anthropometric parametrs of the maxillary central incisor in patients with generalized periodontitis and various blood types.

The article presents the results of treatment of 157 patients with generalized periodontitis depending on blood type. In the blood of patients with generalized periodontitis was determined: the number of erythrocytes, the number of leukocytes, platelets, neutrophils, leukocyte intoxication index, fibrinogen. After treatment, analysis of blood cell composition showed that 1 year after treatment of generalized periodontitis, carriers of 0 (I) and A (II) blood type increased the number of erythrocytes in the blood – 1.2 times. At the same time, a decrease in the number of leukocytes on average was determined by 1.4 times, and leukocyte intoxication index values – by 2.0 times in representatives of 0 (I) and B (III) blood type; neutrophils – 1.4 times in people with A (II) blood type; platelets – 1.3 times in carriers with 0 (I) and AB (IV) blood type, according to data before treatment. The improvement of hematological and hemostasiological indicators of blood in patients with generalized periodontitis indicates a positive effect on the organs and systems the medicines we have prescribed, the positive effect of which is reflected, in particular, on the complex of tooth-retaining tissues.
Keywords: generalized periodontitis, erythrocytes, leukocytes, blood type

The article presents the results of treatment of 157 patients with generalized periodontitis depending on blood type using polypeptide drugs. The concentration of total protein, C – reactive protein, IgG, TRACP, BSALP, albumin, amylase, lipase, Ca, Fe was determined in the oral fluid. The treatment allowed to reduce the content of total protein, C – reactive protein, TRACP in the oral fluid with increasing levels of calcium, Fe, BSALP, in relation to the relevant data before treatment. And also, polypeptide drugs helped to increase the level of albumin in representatives of 0 (I) and A (II) blood type in the oral fluid; contributed to a decrease: glucose, IgG with increasing activity, amylase and lipase in carriers of B (III) and AB (IV) blood type in the oral fluid, in relation to the values before treatment. The dynamics of indicators of oral fluid metabolism with the help of polypeptide drugs, convincingly proves the effectiveness of their use in the treatment of generalized periodontitis in patients with different blood type.