Snail mucin is one of the animal products widely used in cosmetic products. The mucus of Cornu aspersum (C. aspersum) contains compounds that have antibacterial, antioxidant, proliferative, pro-migration, angiogenesis-promoting, and other biological effects. This study aimed to critically analyze and consolidate existing data on the bioactive components of C. aspersum mucus and the mechanisms of their influence on human health, fo cusing mainly on its cosmetic, regenerative, anti-inflammatory, and antimicrobial proper ties. We conducted a literature search analysis on this problem using the following search databases in English: PubMed, PubChem, Mendeley, Google Scholar, Scirus, DOAL, BASE, CORE, Science.gov, and RefSeek up to August 12, 2025. It was shown that snail mucus facilitates wound healing, which could be the prerequisite for the development of innovative formulations for the adjuvant therapy of skin wounds. However, there are problems with the standardization of snail mucus because of the absence of single quality indexes, their limits, and the complicated structure of snail mucins. Moreover, there is a lack of clinical randomized trials evaluating the safety and efficacy of C. aspersum snail
mucus. In conclusion, snail mucus's biological effects deserve further investigation and pave the way for further studies of its potential as a raw material for pharmaceutical products, including the chemical structure of the still unknown molecules, its standardization, nonclinical and clinical studies, and further studies of snail mucus for its usage in cosmetology.
Keywords: Cornu aspersum mucus; mucin; snail secretions; cosmetology; wounds
Abstract: It was synthesized N-[5-(4-fluorobenzyl)-1,3-thiazol-2-yl]chroman-3-carboxamide. The
structure of the title compound was confirmed by 1H NMR spectroscopy and elemental analysis. The
synthesized compound complies with Lipinski, Muegge, Ghose, Veber, and Egan rules. ADME and
toxicity of the compound are analyzed, and Swiss target prediction of the compound has been carried
out to analyze the preferred target. The title compound exhibited remarkable anticancer activity against
all the tested cell lines and was more active than classical anticancer drugs – gefitinib, 5-fluorouracil,
cisplatin, and curcumin. The metabolic pathway mediated by Cytochrome P450 was evaluated for the
title compound. It was found that the main pathways are aromatic hydroxylation of fused benzene ring,
which should not cause toxic effects.
Keywords: thiazole; chroman; virtual screening; drug-like molecules; anticancer activity;
Cytochrome P450; metabolism.