The researchers of the Truskavetsian Scientific School of Balneology have demonstrated that effect of balneotherapy at the Truskavets’ Spa on the physical working capacity of both healthy rats and different categories of patients is ambiguous. It is shown that various variants of actotropic effects are accompanied by characteristic changes in a number of body parameters. The purpose of this study was to identify neuro- endocrine, hemodynamic and metabolic accompaniments of actotropic effects of balneotherapy in men with maladaptation. Material and methods. The object of observation were 34 men (aged 23÷70 years) with maladaptation against the background of chronic pyelonephtis in remission phase, who came for rehabilitation at the Truskavets' Spa. The object of study: PWC, hemodynamics, HRV, EEG, adaptation hormones, blood and urine metabolites. The survey was conducted twice: on admission and after 7-10 dais of rehabilitation. Results. The analysis of individual changes revealed that balneotherapy in 18 patients did not significantly affect the level of fitness. In 9 patients balneotherapy caused an increase in PWC150 (direct difference: 0.57±0.12 W/kg) while in the other 9 patients the level of fitness decreased (direct difference: -0.42±0.03 W/kg). Discriminant analysis revealed 24 variables as characteristic accompaniment of the three variants of actotropic effects of balneotherapy. Among them, 2 are hemodynamic, 13 are neural, which reflect the entropy of EEG and HRV as well as delta-, theta- and beta-rhythms, 2 are endocrine, and 7 are metabolic. Classification accuracy is 100%. Conclusion. The multivariate actotropic effects of balneofactors are due to their multivariate effects on neuro- endocrine regulation and metabolism, which, apparently, is determined by the peculiarities of the individual reactivity of the body.