Abstract

Condensed bicyclic systems with 1,3,4-thiadiazole core being annulated to pyridine or pyrimidine ones occupy prominent place in medicinal chemistry because of their broad spectrum of pharmacological properties. The combination of these heterocyclic systems into a bicyclic scaffold commonly provides much more interest in the enhanced activity profile of its analogs than their parent monocyclic constituents. Thus, a number of pyridines or pyrimidines fused to thiadiazoles are incorporated into a wide variety of therapeutically important compounds
possessing a broad spectrum of biological activities. In the present review we highlight recent advances in the fast-growing research area of thiadiazolo[3,2-a]pyridines and thiadiazolo[3,2- a]pyrimidines chemistry summarizing the existing literature information with respect of their synthetic approaches. Considering such a significant pharmacological potential, as well as wide synthetic possibilities, mentioned fused heterosystems have received considerable attention from scientific community as perspective scaffold for the rational design of drug-likes candidates.