Psoriasis affects about2To of population In 30-40% of occurrences arthropathic
psoriasis (AP) is diagnosed and it leads to 11-19% of disability cases development. The article analyses features of
anamnesis, clinical, instrumental and laboratory tests related to arthropathic psoriasis, considers the relationship of
probable mechanisms of disease aggravation and progression with the definition of a treatment method
influencing the dynamics of a disease course.
The objective of our work was to improve the diagnostics of AP patients taking into account some indicators of
the inrmune-epdocrine system and features of the disease course to specify their role in AP pathogenests and to
develop the system of integrated therapy of patients whose locomotor system is affected due to psoriasis
Tlre possible role of viral persistence as an epigenetic factor in the development of
psoriasis is discussed when a specific antigen (virus, especially type 1,2 (HSV 1,2)) is considered as a trigger factor
for direct or indirect action on immunocompetent cells.
The purposeTo evaluate the peculiarities of blood lyrnphocytes phenotyping in patients with psoriasis and
activated chronic Herpes slmplex virus infection compared to patients with psoriasis, activated chronic Herpes
virus infection, and healthy persons during treatment
The science of micronutrients (MN) remains at the stage of amassing factual material. Hair is a reliable and non-invasive source of information about the MN content in the body, for its metabolism is slow and only long-term disturbances in the concentration of nutrients can be reflected in it. The attention of many researchers has been drawn to the hypothesis of the influence of exogenous and endogenous factors on the hair functional status, especially with regard to essential and toxic MN. Today a tendency towards an increase in the number of paediatric patients with hair diseases ranging from excessive hair loss to various clinical forms of alopecia is observed.
Objectives. The study was aimed to identify the MN imbalance, manifested through the condition and appearance of hair, to follow structural changes in hair and to assess the influence of internal organ pathologies.
Psoriasis is a skin disease that is accompanied by systemic inflammation and affects about 1 to 5% of the population worldwide. The aim of our research was to determine morphological peculiarities of skin lesions in patients with common psoriasis, investigation of the levels of expression of immunohistochemical markers of vascularization.
It has been established that patients with psoriasis, which were under observation, had the skin microbial landscape of the lesions formed mainly of S. aureus, S. epidermidis, S. saprophyticus, Bacillus and Micrococcus genera. The clearest microbial contamination of the lesions has been observed in psoriatic erythroderma, slightly less accentuated skin microbial contamination has been found in patients with the widespread form of dermatitis and the presence of arthropathy, and the least number of microorganisms have been found in patients with common psoriasis without complicated phenomena.