ABSTRACT
Aim: The patterns of qualitative and quantitative changes in the microvascular network in the skin of adult male white rats under of nalbuphine administration.
Materials and Methods: The research employed methods such as vascular bed injection, skin section clearing, and microscopic imaging using an MBI-1 microscope.
Morphometric analysis of the microcirculation vessels was conducted, and statistical processing of the results was performed using specialized software.
Results: The nalbuphine significantly impacted the morphological state of the white rat’s skin after two weeks of administration, with the initial changes
occurring in the blood vessel plexuses. In the injected skin samples, both arterioles and capillaries were dilated, with the diameter of the subpapillary arteriolar
network significantly increasing to 28.62±1.07 μm (control – 22.24±0.73 μm), and the diameter of intrapapillary capillary loops expanding to 6.20±0.11
μm (control – 5.91±0.26 μm). Arterioles exhibited tortuosity. After four weeks, the loops of the vascular plexus lost their delicate, lace-like structure, with
microaneurysms in arterioles and sacculations in venules becoming evident. After six weeks of opioid exposure, significant structural alterations were observed
in the blood vessels of the skin. Capillaries became obliterated, with some destroyed, and this process was accompanied by hemorrhages. The density
of intrapapillary capillary loops decreased significantly to 59.0±2.0 (control – 79.60±2.078), while the trophic activity index increased to 39.490±1.307 μm
(control – 27.172±1.143 μm),
Conclusions: Morphometric analysis of the morphological state of the vascular plexuses in the skin clearly illustrates the relationship between quantitative
and qualitative changes in the structural organization of the microcirculation network under opioid exposure.
KEY WORDS: skin, vessels, morphometry, opioid

Psoriasis affects about2To of population In 30-40% of occurrences arthropathic
psoriasis (AP) is diagnosed and it leads to 11-19% of disability cases development. The article analyses features of
anamnesis, clinical, instrumental and laboratory tests related to arthropathic psoriasis, considers the relationship of
probable mechanisms of disease aggravation and progression with the definition of a treatment method
influencing the dynamics of a disease course.
The objective of our work was to improve the diagnostics of AP patients taking into account some indicators of
the inrmune-epdocrine system and features of the disease course to specify their role in AP pathogenests and to
develop the system of integrated therapy of patients whose locomotor system is affected due to psoriasis

Tlre possible role of viral persistence as an epigenetic factor in the development of
psoriasis is discussed when a specific antigen (virus, especially type 1,2 (HSV 1,2)) is considered as a trigger factor
for direct or indirect action on immunocompetent cells.
The purposeTo evaluate the peculiarities of blood lyrnphocytes phenotyping in patients with psoriasis and
activated chronic Herpes slmplex virus infection compared to patients with psoriasis, activated chronic Herpes
virus infection, and healthy persons during treatment

The science of micronutrients (MN) remains at the stage of amassing factual material. Hair is a reliable and non-invasive source of information about the MN content in the body, for its metabolism is slow and only long-term disturbances in the concentration of nutrients can be reflected in it. The attention of many researchers has been drawn to the hypothesis of the influence of exogenous and endogenous factors on the hair functional status, especially with regard to essential and toxic MN. Today a tendency towards an increase in the number of paediatric patients with hair diseases ranging from excessive hair loss to various clinical forms of alopecia is observed.
Objectives. The study was aimed to identify the MN imbalance, manifested through the condition and appearance of hair, to follow structural changes in hair and to assess the influence of internal organ pathologies.