Increasing incidence of dermatosis at the background of reduced immunological response to the impact
of exo- and endogenous pathogenic agents dictate the necessity of a more profound research of the
problem. In addition, antibiotic and immunosuppressive therapy led to activation of saprobic and
conventionally pathogenic microflora which is believed to play a prevalent role in the development of
dermatosis and, in particular, psoriasis.
Purpose of the research was to study profile of epidermal microflora on the skin of psoriatic patients and
especially on the affected areas in order to determine its impact on the development and course of
psoriasis. 

The herpes simplex virus (HSV) may be not only a nosological disease but also a secondary infection
which may affect the severity of the course of other dermatoses.
On time diagnostic's and proper therapy of the psoriasis progression help related specialists prevent
occurrence of such diseases. Therefore, the goal of our research is to provide comprehensive
examination of the persons suffering from psoriasis, especially those with the severe or atypical course of
the disease, in order to detect herpetic infection and improve further treatment of these patients. 

Psoriasis is one of the most common chronic, non-communicable, immune-mediated skin diseases,
affecting over 125 million people worldwide. The means and dosage forms of topical therapy depend
usually on the clinical course pathological process. In recent years, both in the world and in Ukraine,
narrowband UVB phototherapy of psoriasis, because of its efficiency, safety and availability has become a
technique of choice in the treatment of psoriasis patients with different clinical course. NB UVB therapy
method is self-contained and can be used as monotherapy, but combination of emollient, in our view,
adds treat certain advantages. The aim of our study was to examine and evaluate the effectiveness of this
method phototherapy combination of emollient in the treatment of psoriasis. 

Acne is a multifactorial chronic inflammatory disease with primary damage to the pilosebaceous unit and
the polymorphic clinical manifestations associated with overproduction of sebaceous glands,
pathological desquamation of the sebaceous epithelium of the sebum follicles, activation of saprophytic,
conditionally pathogenic microorganisms, and psychoemotional disorders. This is undoubtedly one of
the most common dermatoses in clinical practice, accounting for 20-25% of dermatology consultations.
Today, especially in wartime, acne vulgaris remains a socially important problem in approximately half of
patients with psychoemotional disorders, mainly of a depressive and anxiety associated nature with a
sharp decrease in the quality of life of patients. 

ABSTRACT
Aim: The patterns of qualitative and quantitative changes in the microvascular network in the skin of adult male white rats under of nalbuphine administration.
Materials and Methods: The research employed methods such as vascular bed injection, skin section clearing, and microscopic imaging using an MBI-1 microscope.
Morphometric analysis of the microcirculation vessels was conducted, and statistical processing of the results was performed using specialized software.
Results: The nalbuphine significantly impacted the morphological state of the white rat’s skin after two weeks of administration, with the initial changes
occurring in the blood vessel plexuses. In the injected skin samples, both arterioles and capillaries were dilated, with the diameter of the subpapillary arteriolar
network significantly increasing to 28.62±1.07 μm (control – 22.24±0.73 μm), and the diameter of intrapapillary capillary loops expanding to 6.20±0.11
μm (control – 5.91±0.26 μm). Arterioles exhibited tortuosity. After four weeks, the loops of the vascular plexus lost their delicate, lace-like structure, with
microaneurysms in arterioles and sacculations in venules becoming evident. After six weeks of opioid exposure, significant structural alterations were observed
in the blood vessels of the skin. Capillaries became obliterated, with some destroyed, and this process was accompanied by hemorrhages. The density
of intrapapillary capillary loops decreased significantly to 59.0±2.0 (control – 79.60±2.078), while the trophic activity index increased to 39.490±1.307 μm
(control – 27.172±1.143 μm),
Conclusions: Morphometric analysis of the morphological state of the vascular plexuses in the skin clearly illustrates the relationship between quantitative
and qualitative changes in the structural organization of the microcirculation network under opioid exposure.
KEY WORDS: skin, vessels, morphometry, opioid