УДК 534.05:616-008.842/.848

The ever-increasing harmful effect of endo- (products of inflammatory processes of genital tissues) and exogenous factors (environmental conditions) on the body of women and animals (cows) leads to a substantial decrease in ova fertilisation during mating and artificial insemination. Therefore, the purpose of this study was to identify changes in the signs of physical condition (colour, consistency, fluidity, impurities, etc.) and ratios (homeostasis) of H2O mass, organic (OS) and inorganic (IS) substances of uterine-vaginal mucus (UVM) should be used to assess their harmful effect on the fertilisation of cows after their first insemination. The following methods were used for this study: ocular estimate of the physical condition of freshly obtained mucus; gravimetric assessment of the features of changed mass parameters of its dry residue (DR) components; mathematical and statistical analysis of certain indicators. Determined by the gravimetric method, the features of the imbalance of mass (g, mg), its distribution (%) and ratios (Im:1, Ic:1) in the system of the “medium — substance” type due to the harmful effects of endogenous factors (products of inflammatory processes) indicate that the secretions of the genitals released during oestrus are characterised not only by changes in signs, but also ±2-4 times different from the norm (control) indicators of the mass of components. Under such circumstances, the distribution of substances in the DR samples of the experimental group is expressed by the series, where the mass OS1˃IS˃OS2, but in the control group — OS1˃IS˃OS2. This means that the products of inflammatory processes released by the genitals of cows change the norm of homeostasis of the mass (distribution of components) of OS and IS of the biological system of the “medium — substance” type. Indicators of the obtained mass ratios between component pairs H2O: DR; H2O: OS2, H2O: OS1,H2O: IS (control group — 63:1, 586:1, 231:1, 109:1; experiment group — 42:1, 310:1, 87:1, 112:1), except for the H2O: IS pair (P˂0.05), indicate the presence of probable changes in the homeostasis of OS and IS in the “H2O — components” system. The high probability (P˂0.02; ˂0.001) of the detected changes is inherent in the “DR –components” system, namely: if the average ratio indicators of pairs DR: OS2; DR: OS1; DR: IS samples of the control group are 9:1, 4:1, 2:1, then the same indicators in the experimental group are 7:1, 3:1, 2:1, respectively