Результати дослідження клінічно-інструментальних показників стабільності дентальних імплантатів на хірургічному та ортопедичному етапах стоматологічного лікування пацієнтів.

УДК: 616.314-089.843:616.716.85018.43]-071/.072

Стабільність розташування імплантатів в тканинному оточенні щелеп є важливим фактором, який впливає на планування методики встановлення та навантаження дентальних імплантатів(ДІ).Згідно літературних джерел та практичних рекомендацій вважається,що початкова механічна стабільність і відсутність будь-яких небажаних мікрорухів при досягненні біологічної стабільності є важливими морфологічними умовами необхідними для адекватної підготовки ДІ до функціонального навантаження при протезуванні.Оцінка наявних на даний момент методів вимірювання стабільності  ДІ чітко демонструє потребу в неінвазивному, кількісному, повторюваному та надійному способі її вимірювання.Ще у 1996 році Meredith N. та співавтори вперше повідомили про можливості використання аналізатора резонансної частоти (RFA)для оцінки стабільності ДІ шляхом визначення частоти вібраційних сигналів багаторазово скерованих на поверхню датчика уведеного у ДІ.Чим міцніше об'єднання ДІ з кістковою поверхнею,тим резонанс виникає на вищій частоті.Застосовуючи цю інноваційну цифрову методику,ми протягом трирічного періоду провели дослідження та аналіз даних RFA стабільності ДІ у хворих з дефектами зубних рядів.Вимірювання інструментальних показників RFA здійснювали за допомогою цифрового пристрою Osstell в одиницях ISQ під час встановлення та перед перед функціональним навантаженням протезних конструкцій на ДІ у ранньому періоді загоєння впродовж 2-4 місяців та відтерміновано - через 4-6 місяців.Для визначення успішності ДІ використовувався статистичний аналіз показника міжквартильного оптимуму отриманих цифрових значень RFA на етапах раннього та відтермінованого протезування у порівнянні з висхідними даними після уведення ДІ.На основі аналізу отриманих даних RFA при імплантації виявлено,що чим меньший міжквартильний діапазон показників ISQ стабільності ДІ на хірургічному та ортопедичних етапах імплантаційного лікування хворих,тим сприятливішим буде поєднання первинної та вторинної стабільності ДІ,що приведе  до кращої остеоінтеграції.

Ключові слова: дентальні імплантати,біомеханічна  та біологічна стабільність імплантатів у кістковій тканині,функціональне навантаження імплантатів,резонансно-частотний аналіз стійкості дентальних імплантатів.


The stability of implant positioning in the tissue surrounding the jaws is an important factor influencing the planning of the methodology for placement and loading of dental implants (DI). According to literature sources and practical recommendations, it is considered that initial mechanical stability and the absence of any undesirable micro-movements upon achieving biological stability are important morphological conditions necessary for adequate preparation of DI for functional loading during prosthetic rehabilitation.The assessment of current methods for measuring DI stability clearly demonstrates the need for a non-invasive, quantitative, repeatable, and reliable method of measurement. As early as 1996, Meredith N. and co-authors first reported the possibilities of using a Resonance Frequency Analyzer (RFA) to assess DI stability by determining the frequency of vibration signals repeatedly directed at the sensor surface inserted into the DI. The stronger the union of the DI with the bone surfaces, the resonance occurs at a higher frequency. By employing this innovative digital method, we conducted a three-year study and analysis of RFA data on DI stability in patients with tooth arch defects. Instrumental RFA measurements were performed using the Osstell digital device in ISQ units during placement and prior to functional loading of prosthetic constructions on DI in the early healing period within 2-4 months and delayed loading - after 4-6 months. Statistical analysis of the interquartile optimum indicator of obtained digital RFA values ​​was used to determine the success of DI at the stages of early and delayed prosthetic rehabilitation compared to baseline data after DI insertion. Based on the analysis of the obtained RFA data during implantation, it was found that the smaller the interquartile range of ISQ stability indicators of DI at surgical and orthopedic stages of implant treatment in patients, the more favorable the combination of primary and secondary DI stability, which will lead to better osseointegration."

Key wods:dental implants, biomechanical and biological stability of implants in bone tissue, functional load of implants, resonance-frequency analysis of dental implants.


Докладніше

CORRELATING FEATURES BETWEEN DENTAL AND PULMONARY DISEASE

616.31:616.24(048.8)

Abstract. The article reviews the factors of dental exposure that may have a potential risk for the development of pulmonary diseases.

Objective. To analyze the current national and foreign literature on the relationship between dental health and pulmonary disease, while exploring current data and future research directions.

Materials and Methods. The study used analytical and bibliosemantic methods. The search for scientific infor- mation on the medical research topic was conducted in the databases of the following search engines: the electronic library of abstracts and theses of the Vernadsky National Library of Ukraine, PubMed, Medline, MedNet, Embase, BMJ Group, Free Medical Journals, Free Medical Book, Scirus.

Research results and discussion. The analysis of literature data provides evidence of a host-pathogen interac- tion associated with the oropharyngeal microbiome and its metabolites.

Cross-species interactions between microorganisms create a symbiotic relationship with the host macroorganism by acting as a "sensor", "mediator" and "killer" of pathogens to prevent pathogens from colonising and integrating into the host. Conversely, the immune response of the macroorganism must balance between inflammation to destroy the pathogen and prevent unwanted immune responses against host tissue and its own microorganisms. When the composi- tion, activity and function of the oral microbiome is disturbed, it causes dysbiosis. In the presence of orthopaedic struc- tures in the oral cavity, the eubiotic balance is more or less shifted to a pathogenic state.

The article analyses the influence of structural materials and methods of their production, which are mainly used in prosthetic dentistry, on the formation of biofilm, changes in the oral microbiome, and the spread of an inflammatory reaction in the prosthetic bed.

The oral cavity is the first line of defence of the immune system against most foreign pathogens, which can affect the immune and inflammatory reactions of the body as a whole. This factor can spread systemic inflammation that affects other organs, including the lungs. The oral microbiota can influence the microbial community in the lungs through mi- croaspiration and dispersal. In general, the oral-pulmonary axis can exchange components of its microbiome

The most common respiratory diseases associated with dust among dentists and its irritating effects on the res- piratory system are also analyzed.

In general, ultrafine and nanoscale airborne particles have been studied for a long time, but with the development of new technologies, their acute or chronic effects on the health of healthcare workers associated with dental practice require more detailed study.

Conclusion. Understanding the relationship between oral health and systemic diseases, including pulmonary diseases, and studying a multidisciplinary approach to the treatment of a particular disease can be important in terms of extending healthy life expectancy and improving its quality. For effective health management, it remains an unsolved issue whether it is possible to prevent systemic diseases by influencing oral diseases (and vice versa).

Keywords: microbiome, dysbiosis, bacterial adhesion, pulmonary diseases, oral health, biofilm, aerosols, nano- particles, prosthetic materials, cross-species interaction of microorganisms.

Докладніше

Analysis of anti pro-oxidant system of test animals in the dynamics of the wound process at local application of hydrogel dressings

UDC 616-001.4-085.262.1:612.015.11]-092.9

Introduction. The development of the inflammatory process is always accompanied by the activation of lipid peroxidation, which is caused by tissue hypoxia. This, in turn, catalyzes a change in the physiological parameters of the antioxidant system.

The aim of the study is to analyze the dynamics of the antioxidant balance of wounds in an experiment using hydrogels saturated with silver ions and an antioxidant drug for the local treatment of inflammatory processes.

Object and research methods. The experimental study was carried out on 80 Wistar rats weighing 150 to 200 grams. Animals were removed from the experiment. for 3, 7, 10, 14 days. Catalase activity in the dynamics of the wound process was determined.

Research results and their discussion. The content of catalase on the 7th day in the third experimental group is 0.51±0.03 μKat/l. On the 10th day, the indicator of the antioxidant system in the second (0.44±0.05 μKat/l) and third experimental groups was 0.42±0.02 μKat/l. At the final stage of the study on the 14th day, the analysis of catalase content showed that in all animals with a simulated inflammatory process, the indicator of antioxidant activity had no significant differences between themselves and, importantly, with the indicators of intact animals (0.33±0.01 μKat /l). The indicators of the control (0.33±0.04 μKat/l) and experimental groups were as follows: the first experimental group – 0.32±0.06, the second experimental group – 0.36±0.04, the third experimental group – 0, 38±0.06 μKat/l. Antioxidant protection was supplemented by local release of a drug with antioxidant action from the hydrogels, which contributed to a reduction in the intensity of free radical oxidation processes. That is, in almost all groups of animals, which were simulated purulent-inflammatory wounds, indicators of catalase activity approached the level of intact animals already on the 14th day.

Conclusions. Application for local treatment of hydrogel bandages saturated with an antioxidant drug, which is released into the wound surface for a long time, promotes the activation of antioxidant protection and suppresses the processes of free radical formation.

Докладніше

CYTOLOGICAL ASSESSMENT OF HEALING ODONTOGENIC INFLAMMATORY PROCESSES WHEN APPLYING HYDROGELS

 INTRODUCTION: Odontogenic inflammatory processes constitute a significant part among maxillofacial disorders, as well as among all inflammatory processes in organism. The author used hydrogels saturated with silver ions and an antioxidant drug for local treatment of odontogenic abscesses and phlegmons.
AIM OF THE STUDY. To conduct cytological assessment when applying hydrogels saturated with silver ions and an antioxidant drug for local treatment of odontogenic abscesses and phlegmons.
STUDY SUBJECT AND STUDY METHODS. 50 patients with odontogenic abscesses and phlegmons of maxillofacial area had been examined. To study the dynamics of the inflammatory process, cytology was performed on days 1, 3, 5, 7, 10.
STUDY RESULTS AND THEIR DISCUSSION. No differences were found in both groups of patients on the first day of treatment. On the second or third day, there was a higher number of red blood cells and a significant decrease in the number of neutrophilic granulocytes in the study group than in the comparator group. In the fibrin strands, accumulation of single macrophages, histiocytes, fibrocytes and monocytes were noted. During analysis of cytograms, an increase in the number of erythrocytes, histiocytes, fibroblasts, almost complete absence of neutrophilic granulocytes and single macrophages in the main group were observed on the 4-5 day, indicating the formation of granulation tissue and accelerated onset of proliferation. On the sixth day, patients of the study group had almost no neutrophils and no signs of inflammation, unlike patients in comparator group.
CONCLUSIONS. Cytology results has shown that application of hydrogels saturated with silver ions and an antioxidant drug for local treatment of odontogenic abscesses and phlegmons accelerates the healing time of postoperative wounds. 

Докладніше

CYTOLOGICAL ASSESSMENT OF HEALING ODONTOGENIC INFLAMMATORY PROCESSES WHEN APPLYING HYDROGELS

 INTRODUCTION: Odontogenic inflammatory processes constitute a significant part among maxillofacial disorders, as well as among all inflammatory processes in organism. The author used hydrogels saturated with silver ions and an antioxidant drug for local treatment of odontogenic abscesses and phlegmons.
AIM OF THE STUDY. To conduct cytological assessment when applying hydrogels saturated with silver ions and an antioxidant drug for local treatment of odontogenic abscesses and phlegmons.
STUDY SUBJECT AND STUDY METHODS. 50 patients with odontogenic abscesses and phlegmons of maxillofacial area had been examined. To study the dynamics of the inflammatory process, cytology was performed on days 1, 3, 5, 7, 10.
STUDY RESULTS AND THEIR DISCUSSION. No differences were found in both groups of patients on the first day of treatment. On the second or third day, there was a higher number of red blood cells and a significant decrease in the number of neutrophilic granulocytes in the study group than in the comparator group. In the fibrin strands, accumulation of single macrophages, histiocytes, fibrocytes and monocytes were noted. During analysis of cytograms, an increase in the number of erythrocytes, histiocytes, fibroblasts, almost complete absence of neutrophilic granulocytes and single macrophages in the main group were observed on the 4-5 day, indicating the formation of granulation tissue and accelerated onset of proliferation. On the sixth day, patients of the study group had almost no neutrophils and no signs of inflammation, unlike patients in comparator group.
CONCLUSIONS. Cytology results has shown that application of hydrogels saturated with silver ions and an antioxidant drug for local treatment of odontogenic abscesses and phlegmons accelerates the healing time of postoperative wounds. 

Докладніше
1 2 3 4
Назад Вперід