Abstract: Triazolo[3,4-b][1,3,4]thiadiazole core is the condensed thia/aza-containing bicyclic system combining 1,2,4-triazole and 1,3,4-thiadiazole rings, which represent an interesting class of heterocyclic compounds. Thus, functionalized derivatives incorporating triazolo[3,4-b]thiadiazole are of essential significance and particular interest for both the pharmaceutical and agrochemical industries due to their wide spectrum of biological properties. Considering the wide synthetic possibilities as well as a diverse range of pharmacological activities, triazolo[3,4-b][1,3,4]thiadiazoles have received considerable attention from the scientific community as a prospective structural scaffold for rational drug-like molecules build-up. In this review, we have attempted to summarize the literature data about the main synthetic approaches for obtaining triazolo[3,4-b][1,3,4]thiadiazole-based molecules as promising objects for modern bioorganic and medicinal chemistry.
Keywords: triazolo[3,4-b][1,3,4]thiadiazoles; fused heterocycles; synthesis; chemical modification; multistep transformation; cyclocondensation; molecular hybridization.

Triazolo[3,4-b][1,3,4]thiadiazole molecules are found to be important tools in modern bioorganic and medicinal chemistry. This condensed system successfully combines two pharmacologically significant five-membered heterocycles – 1,2,4-triazole and 1,3,4-thiadiazole, which causes much more interest in the enhanced activity profile of its analogs than their parent separate constituents. It’s considered that the triazoles fused to thiadiazoles exhibit various therapeutically important properties, probably due to the existence of N-C-S fragments in their structures. In this review, we presented the summarized literature data about the diversity of pharmacological effects of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole based compounds as promising objects for the rational design of drug-like molecules.

UDC. 616.314.17-008.1-084:615.015

Abstract. The purpose of the study was to optimize clinical classification, secondary prevention and treatment of complicated stage III and IV of pressure ulcers caused and prolonged or persistent loss of motor activity, arise as a result of injuries or diseases of the spinal cord and brain, severe somatic pathology, accompanied by impaired innervation and tissue trophism which are based on clinical observation and complex strategy in a palliative care unit or department. It is worth emphasizing that in addition to specific preventive measures, it is necessary
to treat any concomitant diseases and syndromes that contribute to the formation of bedsores of various localization, especially in diabetes, occlusive diseases of the arteries, etc., to ensure adequate analgesia and correction of the water-electrolyte balance. In our study, the total sample consisted of 412 patients aged 40-93 years: 174 men and 238 women, who were treated inpatient for 10 years in the palliative care department of the Lviv Regional Medical Association "Clinical Hospital of Planned Treatment, Rehabilitation and Palliative Care" , separate unit "4 hospital" and medical center "Salutas", Lviv, Ukraine. In their work, they used plans for the
care and complex treatment of bedsores according to the TIME and DOMINATE strategies, which included adequate nutritional support, orthopedic decompression of problem areas, remediation of bedsores (including surgical treatment if necessary) with antiseptics. Adequate care and treatment of patients with chronic wounds and,
in particular, pressure ulcers is possible only the DOMINATE strategy, in the presence of colliquative (wet, moist) necrosis or demarcated (limited) dry of areas of necrosis. It is necessary to take into account the peculiarities of the wound process in the formation of purule nt pressure ulcers, the composition of the microflora, which affects the course of healing and requires not only antibiotic therapy but also the use of topical antiseptics, providing appropriate care, monitoring the dynamics of the bedsores wound process and correcting local venous and/or lymphatic stasis, background and comorbid pathology.
Keywords. Complicated stage III and stage IV decubitus ulcers, soft tissue necrosis, purulent-necrotic complication, putrefactive phlegmon, clinical strategy, secondary prevention, complex surgical treatment.

UDC 347.77+347.77.028.4): (378+174):004.4 

Abstract. The article presents the experience of implementing the principles of academic integrity at the Danylo Halytsky Lviv National Medical University (LNMU), program reports at the meeting of the rectorate, and the experience of implementing search and analytical anti-plagiarism programs and tools. The purpose of the article is to study and improve measures to combat plagiarism in medical institutions, taking into account the experience of implementing academic integrity and examination of scientific works, current legislation, regulatory orders
and regulations. Prevention of academic plagiarism at the university is carried out by issuing and distributing methodological recommendations that define uniform requirements for proper citation of materials used in scientific works; introduction of special classes at faculties and institutes on the basics of adequate research and
writing scientific work, which emphasize the correct use of information from other sources in scientific works and the avoidance of plagiarism, rules for describing sources and citation. It is argued that with the development of modern computer technologies, the issue of copyright increasingly attracts the attention of scientists.
The issues of improving measures to combat plagiarism and other cases of violation of the Code of Academic Ethics, studying the effectiveness of specialized software, and creating specialized courses for applicants are relevant. At LNMU, the complex semantic analysis of scientific works is performed in personal offices by
«StrikePlagiarism» and «UNICHEK» systems; with the help of «Plagiarism Detector Pro» programs (on the network and University repository); «AntiPlagiarism.NET» (in the university repository), “ETXT Antiplagiarism”
("ETXT Antiplagiat") only in the microrepositories of structural units, "AdvegoPlagiatus", versions 1.3.1.7, 1.3.3.1, 1.3.3.2" – at some theoretical and clinical departments. In force majeure conditions, the desktop program "Plagiatism Detector Pro" and the direct involvement of electronic depositories are optimal. The instructions and sections of the websites of the structural units should contain links to the best programs and services for the initial check for plagiarism, which is a must. implementation of the academic integrity strategy. the software installed and
operating at the medical university meets modern criteria for checking Cyrillic and Latin scientific texts, which should be brought to the attention of departments and other structural units, and timely issues are the creation of appropriate conditions for the timely detection and prevention of violations of academic integrity; detection of
academic plagiarism and publication of anti-plagiarism examination results.
Keywords. Academic integrity, anti-plagiarism examination, software.