Pain is an interdisciplinary problem at the border of medicine, psychology, sociology and economics. Pain syndrome reduces the quality of life of patients, affects work productivity, social adaptation, and in most cases is poorly amenable to treatment. Therefore, a multidisciplinary approach to the diagnosis and treatment of pain syndrome is important, which should take into account the peculiarities of the patient’s perception of pain, the patient’s psycho-emotional state, individual life experience and previous experience of feeling pain, which will make it possible to improve the effectiveness of treatment, reduce the number of used painkillers and, accordingly, improve patient’s quality of life. Based on the analysis of modern literary sources, the article presents an expanded concept of pain, pathogenetic and biochemical mechanisms of its occurrence, approaches to treatment. Link: