UDC 611-018.4:616-085

Introduction. Osteopenia is a multifactorial condition that develops under estrogen deficiency and reduced mechanical loading. Experimental models of postmenopausal osteoporosis enable investigation of bone remodeling mechanisms and evaluation of corrective interventions. Aim. To experimentally evaluate the effect of low-intensity whole-body vibration on bone remodeling, mineral component, and nanocomposite structural organization in ovariectomized rats. Materials and Methods. The study was performed on Wistar rats divided into three groups: SHAM-operated, ovariectomized (OVE), and ovariectomized treated with whole-body vibration (OVE+WBV; 50 Hz, 0.3 g, 30 min/ day, 5 days/week) over 24 weeks. Bone remodeling markers (osteocalcin, alkaline phosphatase, TRAP-5b) were assessed, and the structural characteristics of the mineral phase were analyzed using X-ray diffraction. Results. Ovariectomy resulted in a significant decrease in the bone mineral component as early as week 8, which persisted throughout the study. Whole-body vibration prevented early bone loss during weeks 8–16, as evidenced by higher crystalline phase fraction and increased crystallite size compared to the OVE group. Biochemical markers confirmed increased bone remodeling after ovariectomy, while vibration partially modulated these changes. At week 24, the effect of vibration was no longer statistically significant. Conclusions. Low-intensity whole-body vibration attenuates early post-ovariectomy bone loss and modulates bone remodeling processes, reflected by changes in biochemical markers and mineral phase structure. The effect is most pronounced during the early post-ovariectomy period.