Abstract: Triazolo[3,4-b][1,3,4]thiadiazole core is the condensed thia/aza-containing bicyclic system combining 1,2,4-triazole and 1,3,4-thiadiazole rings, which represent an interesting class of heterocyclic compounds. Thus, functionalized derivatives incorporating triazolo[3,4-b]thiadiazole are of essential significance and particular interest for both the pharmaceutical and agrochemical industries due to their wide spectrum of biological properties. Considering the wide synthetic possibilities as well as a diverse range of pharmacological activities, triazolo[3,4-b][1,3,4]thiadiazoles have received considerable attention from the scientific community as a prospective structural scaffold for rational drug-like molecules build-up. In this review, we have attempted to summarize the literature data about the main synthetic approaches for obtaining triazolo[3,4-b][1,3,4]thiadiazole-based molecules as promising objects for modern bioorganic and medicinal chemistry.
Keywords: triazolo[3,4-b][1,3,4]thiadiazoles; fused heterocycles; synthesis; chemical modification; multistep transformation; cyclocondensation; molecular hybridization.