Introduction & Objectives: The COVID-19 pandemic has made adjustments both in the general life of people and in the medical practice of doctors of many specialties. In addition, doctors - dermatovenerologists at daily appointments increasingly consult users with drug-induced rashes that occurred after treatment of COVID-19. Medicinal lesions of the skin with a viral coronavirus infection are necessarily associated with a large number of drugs of various pharmacological groups prescribed to the patient, which, interacting, can have a toxic effect on human protection. One of the most important manifestations of the toxic effect of drugs on the human body is toxic epidermal necrolysis (TEN).
Purpose The research method was to analyze the anamnestic data from TEN and characterize the amino acid composition of the blood serum of such patients with damage to more than 50% of the skin area.
Materials & Methods: 6 used TENs were under our observation, during periods of various diseases (initial, acute) that had undergone COVID-19, the area of the affected skin was determined by the rule of “nines”, the amino acid composition of blood serum was determined by the method of thin-layer two-dimensional chromatography.
In order to determine the indicators of carbohydrate metabolism and their influence on the course of superficial candidiasis, 97 patients with different severity of this disease were examined.The study of carbohydrate metabolism included the determination of fasting blood sugar level to detect the overt diabetes and glucose tolerance test (with the load of 75 g of glucose).The impaired glucose tolerance was detectedin 36 patients, so their levels of
glycosylated hemoglobin and fructosamine wereadditionallydetermined.HbA1c level was determined in whole blood by ion exchange chromatography. Fructosamine was measured by kinetic colorimetric method in both serum and plasma.Blood sampling was performed on an empty stomach from the cubital vein. The studies were carried out immediately after sampling.The Sentinel CH test system from Intero (Italy) and a spectrophotometer with a 405-425 nm filterwere used for the research.
Results: The research showed that in the group of patients with candidal lesions, there is a direct dependence of HbA1c and fructosamine on the severity of the disease.In patients with minimal and moderate candidal lesions, an increase in HbA1c and fructosamine indicators was observed compared to similar indicators in the control group by 1.54 and 1.21 times respectively. In patients with significant candidal lesions and relapses, the concentration of HbA1cincreased by 2.59 timesand of fructosamineby 2.26 times in relation to the indicators of the control group.
Psoriasis is related to the systemic diseases characterised by a complex of mutually conditioned pathogenetic links (immune, neuro-endocrine, infectious, etc.). Microbiocenosis of both healthy and pathologically altered skin can serve thepoint to assess the health of macroorganism. In chronic dermatoses a qualitative and quantitative change in skin microbial associations is observed. Changes in macroorganismare reflected in disorders of microbial landscape of all skin topographic zones. It should be noted, that the study of microbial skin flora in psoriatic patients is episodic and unstructured. Despite loads of suggested methods and therapeutic means used to treat psoriatic patients, their efficacy remains not high due to the uncertainty of aetiology, disease pathogenesis multi-factority and polymorphism of clinical manifestations. The purpose of our study was to study changes in microbial flora of psoriatic patients skin under NBUVB application
Making the diagnosis ad oculus in dermatovenereology has been used in practice from ancient times and to the present day. However, modernity and adherence to protocols require dermatologists to use in their practice a number of instrumental and hardware associated techniques and methods for making a diagnosis, which allow determining not only the type, but also, most importantly, the cause of the disease. An early diagnosis is often a decisive factor in the treatment of patients. The punch biopsy followed by histopathological examination is usually the key research method to make or confirm the final diagnosis in complex dermatology cases.