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More than 82 % of women of reproductive age note pain in the mammary gland. Every fifth woman feels severe pain(mastalgia) and swelling (mastodynia) in the mammary gland. Cyclic mastalgia is combined with hyperprolactinemia.Hyperprolactinemia occurs when dopamine does not suppress pituitary function enough to reduce prolactin release. Agni castifructus, known for its dopaminergic activity, relieves pain and discomfort in the mammary glands. 50 patients were underobservation. Only 10 % of patients felt mild pain, 32 % experienced moderate pain, 50 % assessed it as severe, and 8 % experiencedextreme pain. After the treatment, the complete absence of pain was noted by 76 % of patients. The results of the conducted studiesindicate a high efficiency of 76 % and the safety of using Agni casti fructus in treating mastalgia and mastodynia. The highefficiency in the treatment of mastalgia and mastodynia with the herbal medicine Agni casti fructus without the additional use of
hormonal drugs can be explained by the fact that this drug normalizes the hormonal balance of a woman. 

Новину відредагував: library-lnmu - 28-10-2025, 15:25

Рatients with diabetes have more complications and higher mortality from COVID-19. This is due to the fact that diabetes impairs the immune response. Hyperglycemia causes a violation of the immune response, which in turn cannot control the spread of pathogenic microorganisms and therefore patients
with diabetes are more susceptible to infections. The purpose of the work ₋₋ analysis of bibliometric databases of literature on new developments in diabetes and COVID-19 and focused on clinical recommendations for patients with diabetes infected with COVID-19. The search methods included a literature review of scientific articles that studied diabetes and COVID-19. According to the results of the analysis of the articles obtained as a result of the search in the PubMed, SCOPUS, Web of Science, MedScape databases, a combination of the terms “diabetes and SARS-CoV-2”, “diabetes and COVID-19”, “pathogenesis of diabetes in case of COVID-19”, "pancreas", "clinical features", "diagnosis", "treatment", "clinical recommendations", we found 32 messages from 2020 to 2022. The main parameters  of the study were outpatients and inpatients with diabetes and COVID-19 of middle and elderly age starting from 46 years and up to 82 years of age in France, China, the USA, Great Britain, in which a nationwide, retrospective, populationbased study was conducted. The following concomitant diseases are included in the main studies: arterial hypertension, cardiovascular diseases, heart failure, chronic kidney disease, chronic obstructive pulmonary disease, myocardial infarction, cerebrovascular diseases. Issues of pathogenetic mechanisms in DM and COVID-19, as well as management of patients with DM and COVID-19 are highlighted.
Key words. Diabetes mellitus, СOVID-19, SARS-CoV-2, angiotensin-converting enzyme-2, cytokines.