Abstract. For the first time in Ukraine, our team successfully applied extracorporeal blood hyperthermia (EBH) within a closed-loop circuit to manage inflammatory conditions of the lungs and pleura. Controlled warming of autologous blood to 38°C and its subsequent reinfusion produced rapid, clinically significant reductions in exudative pleurisy, pleural empyema, and paracancerous inflammatory lesions. Earlier, EBH had been
incorporated into U.S. military field protocols between 2003 and 2007, and it is now formally
included in therapeutic guidelines across the United States, Canada, New Zealand, multiple European nations, and several African healthcare systems. Our findings corroborate international data showing that mild systemic hyperthermia enhances phagocytic activity, improves microcirculation within the pleural cavity, and accelerates resorption of inflammatory exudate while maintaining a favorable safety profile. No severe adverse events or hemodynamic instabilities were observed during or after the procedures in our
cohort. Beyond its direct anti-inflammatory impact, EBH may potentiate antibiotic penetration into pleural tissues, offering a valuable adjunct in the era of rising antimicrobial resistance. Future multicenter trials with larger patient populations and comparative cost-effectiveness analyses are warranted to refine treatment parameters and confirm long-term benefits of this promising modality.
Keywords: inflammatory pulmonary pathology, treatment, extracorporeal blood hyperthermia
Abstract. The healthcare sector is faced with the need to find new innovative and multidisciplinary approaches for the prevention and treatment of Covid, post-Covid, long-Covid, chronic, comorbid disorders. The results of 30 years of experience in the use of halotherapy in the treatment of pulmonary pathology indicate that the authors of the article have established the optimal level of use of halotherapy in pathological pulmonary
processes. At the same time, clinical experience provides evidence for the optimal method of using
the halotherapy method in pulmonary nosologies. The method of using salt therapy in exudative
pleurisy, in fibrinous pleurisy, in fibrotic processes in the lungs has been theoretically substantiated,
developed, and implemented in clinical practice. It has been proven that halotherapy is an effective
treatment method for bronchial asthma, chronic obstructive pulmonary diseases, acute respiratory
viral infections, fibrinous and exudative pleurisy. The therapeutic effect of this method is observed only when using halogenerators with the ability to grind salt in the range of 1-5 microns. Halotherapy sessions in patients with bronchial asthma with mild and moderate severity lead to the development of nonspecific hyposensitization, which in turn provides long-term remission of attacks and reduces the need for
glucocorticosteroid drugs. Halotherapy has a confirmed immunomodulatory effect and activates local and T-cell immunity. It requires further study of the experience of halotherapy, conducting marketing, pharmacoeconomic and comparative analysis.
Keywords: halotherapy, pulmonary pathologies, thoracic pathology, bronchial asthma, fibrinous
pleurisy, post-covid syndrome, patient.