Introduction. A search continues for effective means which may reduce the overload of harmful factors, eliminate the inflammatory process, and reduce stress on the periodontal tissues during the active period of orthodontic treatment. We developed and patented the gel composition (GC) Benzidaflaziverdine prepared based on Proteflazid® (flavonoids) and benzydamine hydrochloride (BH) T-Sept® for the local treatment of the periodontal tissues in the form of a periodontal dressing in the orthodontic patients. 
The aim of this study was to evaluate the cytocompatibility of different combinations of components in gel composition based on flavonoid complex and benzydamine hydrochloride (Benzidaflaziverdine) used for the treatment of periodontal diseases in orthodontic patients. For this, mechanisms of their cytopathic and cytoprotective effects will be explored using cultured human and mouse cells. 
Methods. We studied the effect of different supplements used in GC Benzidaflaziverdine on the viability of pseudonormal human keratinocytes of the HaCaT line and mouse fibroblasts of the BALB-3T3 line, and mouse macrophages of the J774.2 line. Various methods of cell survival assessment were used: MTT-assay, staining of cells with fluorescent dyes Hoechst 33342 and Propidium iodide (PI), as well as a test for the genotoxic effects on cells (DNA 
comet assay). The antioxidant properties of the developed GC variants were evaluated using DPPH (1,1-diphenyl-2-picrylhydrazyl), Merck (Dam-stadt, Germany), and DCFDA-H2 (2’,7’-dichlorodihydrofluorescein diacetate). 
Results. We demonstrated that the Sample containing gel base and BH in the form of a solution (Tantum Verde®) possessed weak prooxidant properties. While the Sample contained gel base, powdered BH (T-Sept®) and Sample containing gel base and powdered BH (T-Sept® and Proteflazid®) possessed pronounced antioxidant properties. 
Conclusions. Tests with DPPH and DCFDA dyes were used to confirm the hypothesis regarding the cytoprotective effect of the patented gel composition Benzidaflaziverdine for local application in the form of a periodontal bandage due to the antioxidant activity of the flavonoid complex, which reaches the maximum level at the 2nd hour of exposure. This gel composition can be recommended for use in clinical periodontology for medical support of  orthodontic patients before and during the active phase of orthodontic treatment.
Keywords: Flavonoid complex, Proteflazid®, benzydamine hydrochloride, gel composition, antioxidant activity, cell culture, periodontal diseases, orthodontic patients.

 It is a well-known fact that teeth extraction induces significant dimensional changes of the alveolar ridge [1, 2, 10]. From the point of view of conventional 2-stage implantation this situation requires grafting of the alveolar sockets before implants placement. Nowadays a variety of materials of different origin are present on the market for appropriate bone substitution (synthetic scaffolds: HA, TCP, Bioglass, coral minerals; Ceramic xenografts: Bio-Oss®, Cerabone®ȎOORJHQLF bone (demineralized, lyophilized); ȎXWRJHQLF ERQH FDQFHOORXV FRUWLFDO etc. The expectations of conventional implantologists from grafting procedure are as following: superior results, higher aesthetics, long term predictability, significantly higher success rate, faster healing etc. [18]. But, being honest, the same results are desirable from the point of view of immediate 1-stage implantation and immediate loading as well... Although the concept of immediate implantation and loading requires no bone substitution, even of fresh extraction sockets, because it relies on natural bone healing under the influence of immedi ate loading, the lack of grafting sometimes leads to inappropriate aesthetic results especially in the aesthetically significant areas as frontal maxilla or mandible. The introduction of platelet-rich fibrin (PRF) and autologous dentin (AD) as a grafting material in maxillofacial surgery and implantology drastically changed the attitude of implantologists to bone substitution and made immediate implantation procedure more predictable [3, 4, 5, 11, 13, 15, 16, 17]. Taking into account that immediate implantation and loading, especially in form of Strategic Implant® approach, is associated with multiple teeth extractions, the use of these extracted teeth in combination with PRF as a grafting material can be a superior technique which provides higher aesthetic and functional results. The aim of this work was to study the effectiveness of AD-PRF composition in immediate implantation and loading in the aesthetically crucial areas.
 

 Manifestation of traumatic disorders is often chracterised by reorganization or ossifcation of the TMJ hematoma, while the use of conservative therapy after TMJ traumatic injuries is often ineffective. The purpose of the preswent work was to study the effectiveness of arthrocentesis in the complex treatment of post-traumatic temporomandibular disorders. 24 patients with a history of mandibular condylar fractures underwent CT, ultrasound and MRI. TMJ arthrocentesis was performed under local anesthesia. After osteosynthesis, the number of patients with stage III according to Wilkes was up to 58.33% while, after splinting- 33.33%. The control ultrasound and MRI carried out 3-6 months after arthrocentesis showed no signs of hemarthrosis in 84.61% of patients with intra-articular disorders of the second degree, and also in 72.72% of patients with internal disorders of the third degree, the position and function of the articular disc being restored. Arthrocentesis with TMJ lavage is a minimally invasive surgical manipulation that has proven useful in temporomandibular disorders of traumatic origin, in particular after fractures of the articular process of the mandible. 

 Introduction. The main purpose of this research was to study the effectiveness of local fbrinolytic therapy in the rehabilitation of patients with traumatic injuries of the zygomatic-orbital complex. Materials and methods. Patients in the control group (15 persons) received in the postoperative period standard antibiotic therapy, and analgesic, antiinflammatory and anti-edematous therapy. Patients in the main group (17) received into the parabulbar tissues an additional injection of „Hemase” 5000 ME once a day, for 4-5 days. The effectiveness of the treatment was compared by determining the state of microcirculation, sensory sensitivity and level of enolase in the venous blood. Results and discussion. The general conjunctival index in the control group was 18.9 ± 1.2 points on the 7th day and 16.1 ± 1.8 points on the 14th day, and 15.7 ± 1.0 (p <0.05) and 11.7 ± 1.1 points (p <0.05), respectively, in the experimental one. The threshold of electrical excitability of the infraorbital nerve in patients of the control group on the 7th day was 68.4 ± 5.2 μA, while in the main one - 48.1 ± 5.3 μA (p <0,05). On day 14, the difference in the excitability threshold was even more pronounced: in the control - 52.9 ± 4.8 μA, in the main group- 33.2 ± 3.4 μA (p <0.05), with the index on the healthy side at 27.1 ± 1.9 μA. It was also found out that, in the control group, the level of enolase on both the 7th and 14th day exceeded the values obtained during the examination of patients in the main group: 24.5 ± 1.5 ng/ml to 19 , 4 ± 1.3 ng/ ml and 15.6 ± 1.4 ng/ml to 15.1 ± 1.5 ng/ml. Conclusions. The obtained data allowed stating that application of the proposed course of postoperative rehabilitation helps restore the conduction of nerve trunks, has an anti-edematous effect on the soft tissues of the infraorbital area and improves the hemodynamics of the suborbital artery and vein. 

 The aim: Scientifc work aims at determining the frequency and nature of disorders in psycho-emotional and autonomic systems in patients with combined trauma of the middle face. Materials and methods: Examination included 112 patients with combined trauma of the middle face.Their psycho-emotional state was assessed using the Impact of Event Scale (IES) and the Hospital Anxiety and Depression Scale (HADS). All patients were tested using questionnaires developed by Wayne A.M.. The Kerdo index was used to assess autonomic tone, while autonomic reactivity was determined using a Czermak-Gering carotid sinus test. Biochemical markers of stress - adrenocorticotropic hormone (ACTH), cortisol and anti-stress system - β-endorphins,and Garkavi L.Kh. adaptation index. Results: Patients with severe traumatic brain injury - 26.78%, and severe fractures of the facial bones - 48.21%. The consequence of traumatic events is the appearance of post-traumatic stress disorders in their mental function. Post-traumatic stress is also manifested at the hematological level in the characteristic stress reactions: the growth in the blood of stress markers - ACTH and cortisol and anti-stress factors, including β-endorphins
Conclusions: Middle facial injuries cause disorders of the psycho-emotional sphere, which are manifested in anxiety and depressive disorders. The post-traumatic period is accompanied by stress disorders, which are confrmed by hematological studies with a signifcant increase in stress markers (ACTH and cortisol) and an insignifcant increase in anti-stress factors in the blood. Insufcient stress-limiting function of the hypothalamic-pituitary system slows down the healing process and requires appropriate correction.