Laser texturing seems to be a promising technique for reducing bacterial adhesion on titanium implant surfaces. This work aims to demonstrate the possibility of obtaining a functionally orientated surface of titanium implant elements with a specifc architecture with specifc bacteriological and photocatalytic properties. Femtosecond lasergenerated surface structures, such as laserinduced periodic surface structures (LIPSS, wrinkles), grooves, and spikes on titanium, have been characterised by XRD, Raman spectroscopy, and scanning electron microscopy (SEM). The photocatalytic activity of the titanium surfaces produced was tested based on the degradation efect of methylene blue (MB). The correlation between the photocatalytic activity of TiO2 coatings and their morphology and structure has been analysed. Features related to the size, shape, and distribution of the roughness patterns were found to infuence the adhesion of the bacterial strain on diferent surfaces. On the
laserstructurised surface, the adhesion of Escherichia coli bacteria were reduced by 80% compared to an untreated reference surface.
Keywords Micro/nano-structured surface, Reduced bacterial adhesion, Ultra-short pulsed laser treatment, Photocatalytic activity

: Hydroxyapatite (HAP) is the most common calcium phosphate ceramic that is used in biomedical applications, e.g., as an inorganic component of bone scaffolds. Nevertheless, fluorapatite (FAP) has gained great attention in the area of bone tissue engineering in recent times. The aim of this study was a comprehensive comparative evaluation of the biomedical potential of fabricated HAP- and FAP-based bone scaffolds, to assess which bioceramic is better for regenerative medicine applications. It was demonstrated that both biomaterials had a macroporous microstructure, with interconnected porosity, and were prone to slow and gradual degradation in a physiological environment and in acidified conditions mimicking the osteoclast-mediated bone resorption process.
Surprisingly, FAP-based biomaterial revealed a significantly higher degree of biodegradation than biomaterial containing HAP, which indicated its higher bioabsorbability. Importantly, the biomaterials showed a similar level of biocompatibility and osteoconductivity regardless of the bioceramic type. Both scaffolds had the ability to induce apatite formation on their surfaces, proving their bioactive property, that is crucial for good implant osseointegration. In turn, performed biological experiments showed that tested bone scaffolds were non-toxic and their surfaces promoted cell proliferation and osteogenic differentiation. Moreover, the biomaterials did not exert a stimulatory effect on immune cells, since they did not generate excessive amounts of reactive oxygen species
(ROS) and reactive nitrogen species (RNS), indicating a low risk of inflammatory response after implantation. In conclusion, based on the obtained results, both FAP- and HAP-based scaffolds have an appropriate microstructure and high biocompatibility, being promising biomaterials for bone regeneration applications. However, FAP-based biomaterial has higher bioabsorbability than the HAP-based scaffold, which is a very important property from the clinical point of view, because it enables a progressive replacement of the bone scaffold with newly formed bone tissue.
Keywords: calcium phosphates; scaffold; biomaterial; compressive strength; bioactivity; biodegradation;
biocompatibility; osteoblast; osteogenic differentiation; cytotoxicity

Алергічний альвеоліт (АА) – це імунологічно індуковане запалення легеневої паренхіми. Це захворювання поширене серед осіб, чия праця пов’язана з сільським господарством. У дощовий сезон алергічним альвеолітом хворіють до 8 % фермерів Англії і близько 4 % у США.

Найбільш поширений показник, який використовують для виявлення активності каріозного процесу є індекс КПВ, однак цей індикатор характеризує ситуацію враховуючи, зокрема, як наслідки нелікованого процесу так і результати лікування, але не описує глибини каріозного ураження у різних твердих тканинах [1]. Особливо це важливо при виявленні демінералізаційного процесу на ранньому
етапі. Тому, розпрацьовані значення, які дають змогу вивчити активність каріозних уражень спираючись на клінічні і та гістологічні дані. До таких критеріїв відносять індекс ICDAS (International Caries Detection and Assessment System) [2, 3, 4], який окрім детальної клінічної картини дає змогу спостерігати за розвитком каріозного процесу та планувати адекватне лікування. 

The importance of evaluating the quality of medicinal products is determined by their impact on public health, therefore there are many analytical methods for controlling the chemical composition and bioequivalence of medicines. Falsification of medicines and determining the composition of generics also remain a serious problem, therefore the search and systematization of modern methods of identifying the quality of medicines and methods of combating illegal medicines are relevant and timely. The purpose of the study is to determine effective methods of assessing the quality of medicines and methods of combating falsified medicines, which would meet the country’s demands in conditions of war and economic crisis. The research used methods of analysis, synthesis, systematization, statistical comparison of groups using Student’s t-test, survey and generalization of results. The obtained results revealed alternative methods of quality control of medicinal products in the conditions of economic and war crisis. We identified the prospect of introducing drug marking and assisting pharmaceutical manufacturers and distributors in drug marking. A low level of awareness of the population regarding the methods of assessing the quality of medicinal products and the algorithm of actions in case of detection of low-quality medicinal products was revealed. Among the doctors, there was also an insufficient level of knowledge regarding the assessment of the quality of medicines, which requires the introduction of training of doctors in this field and educational work among the population.