Stevens–Johnson syndrome (SJS), which is a drug-induced disease in 50% of cases, is increasingly common in everyday practice. A determining role in the pathogenesis of pathological conditions (inflammation, shocks of various genesis, etc.) plays a unique extra- and intracellular messenger, i. e., the nitrogen oxide (NO) system acts as an endogenous regulator in various dermatoses. In physiological concentrations, NO interacting with reactive oxygen species exhibits antioxidant properties, in case of metabolic disorders associated with the NO accumulation in tissues, and said reactions promote highly toxic substances adversely affecting the disease course. The NO biological action wide scope determines the interest in studying the NO-NOS system (nitrate ions (NO3-), nitrite ions (NO2-)) in patients with SJS, which is accompanied by the involvement of all body systems and defines the disease prognosis.
Acne remain an immediate problem in dermatology due to the tendency for increase of severe forms with frequent recurrence and damage of significant skin areas, which are the causes of temporary impaired productivity and reduced social activity in patients. This determines its important medical and social role. The aim of our research was to study the indicators of skin and intestine microbiocenosis and immunological parameters in patients with acne.
The high incidence of acne among teenagers, adolescent and young people indicates an important medical and social significance of the problem. In literary sources there is only a few reports about the possible role of stress, neuroendocrine pathology and the development of metabolic syndrome in the pathogenesis of acne, but the given data are often contradictory and insufficiently reasoned, which determines the relevance of further research in order to optimize the treatment and prevention of exacerbations of dermatosis.
Urticarial vasculitis is an eruption of erythematous wheals that clinically resemble urticaria but histologically show changes of leukocytoclastic vasculitis that may be divided into normocomplementemic and hypocomplementemic variants.
The analysis of fusion methods at the pixel level is carried out in the paper. Their mathematical models in the MATLAB package are implemented. The most effective methods of visible and infrared ranges image fusion are determined by evaluating the effectiveness of methods using the authors' proposed improved method of evaluating the informativeness of images and known metrics. These studies were conducted on a set of test images consisting of ten pairs of spatially synchronized images obtained in the visible and thermal ranges of electromagnetic waves.