There is a group of coagulation inhibitors, which are antiphospholipid antibodies (APLA). In patients with different phospholipid antibodies, recurrent thrombolytic therapy complications, brain lesions and pregnancy pathology were observed, which allowed identifying APLA syndrome

Making the diagnosis ad oculus in dermatovenereology has been used in practice from ancient times and to the present day. However, modernity and adherence to protocols require dermatologists to use in their practice a number of instrumental and hardware associated techniques and methods for making a diagnosis, which allow determining not only the type, but also, most importantly, the cause of the disease. An early diagnosis is often a decisive factor in the treatment of patients. The punch biopsy followed by histopathological examination is usually the key research method to make or confirm the final diagnosis in complex dermatology cases.

The increase in the frequency of toxic-allergic diseases is the result of an increase in the number of drugs on the pharmaceutical market, which leads to mass self-medication of the population. Most often, patients seek medical help after self-medication, using drugs of various pharmacological groups. Stevens-Johnson syndrome is the most common side effect of the drug.

A high incidence of acne, tendency to a chronic course with the formation of resistance to treatment and frequent development of deep forms determine the important medical problem. In the examined patients with acne, the qualitative and quantitative changes in the parameters of microbiocenosis of the skin and large intestine were determined, which depend on the clinical course of dermatosis, which indicates the need for additional examination of such patients in order to prescribe a pathogenetically substantiated therapy.