Triazolo[3,4-b]thiadiazoles are a class of heterocyclic compounds, which have attracted great interest in medicinal chemistry owing to their wide range of pharmacological activities. A number of triazoles fused to thiadiazoles are incorporated into a wide variety of therapeutically important compounds possessing a broad spectrum of biological activities. Considering such a significant pharmacological potential, as well as wide synthetic possibilities triazolo-thiadiazoles have received considerable attention from scientific community and are extensively used for construction of prospective drug-likes molecules. In this review, we summarized the literature data about the main synthetic approaches for obtaining condensed heterocyclic compounds based on triazolo[3,4-b][1,3,4]thiadiazole scaffold as promising objects for modern bioorganic and medicinal chemistry. 

A bisphenol-formaldehyde resin was synthesized using the polycondensation method of bisphenol A with formaldehyde. Road bitumen has been modified with this resin. The possibility of its use as a road petroleum bitumen modifier has been established for different contents of the synthesized resin. It has been established that the introduction of synthesized bisphenol-formaldehyde resin into the composition of bitumen significantly increases its heat resistance. The synthesized resin and modified bitumens were characterized using IR spectroscopy. The change in the composition and properties of the bitumen modified with bisphenol-formaldehyde resin has been described. 

Rhodanines are recognized as privileged heterocycles in medicinal chemistry. The main achievements include the development of drug-like molecules with numerous biological activities as well as approved drugs. The Furan nucleus is considered one of the promising heterocyclic cores in medicinal chemistry that showed numerous ranges of activity. The combination of several heterocycles in a one molecule commonly provides much more interest in the enhanced activity profile of its analogs than their parent separate constituents. Such conjugates are promising objects for modern medicinal chemistry. In this review paper recent advances in the synthesis and biological activities rhodanine-furan conjugates which its application in the different field of drug discovery.

The present microreview provides a systematic and illustrative overview of the most typical methods for the synthesis of new thiazolo[3,2-a]pyridines. The material covers key works published since 2020.

УДК 615.2:576.895

Анотація. Протипедикульозні засоби, які реалізуються в Україні, мають 100 % інсектицидну дію, овіцидна дія спостерігається лише при троєкратному застосуванні. Для лікування педикульозу доцільно застосовувати зареєстровані медичні препарати.

Abstract. Antipediculosis products sold in Ukraine have 100 % insecticidal effect, the ovicidal effect is observed only with three times application. For the treatment of pediculosis, it is advisable to use registered medical preparations.