The aim. To study the biocomplex of surfactants based on rhamnolipids Pseudomonas sp. PS-17 (biocomplex PS) as an emulsifier and co-emulsifier by using the method of modelling the composition of emulsions for use in dermatology.
Materials and methods. The biocomplex PS is a biogenic surface-active complex synthesized by bacteria of the genus Pseudomonas, which is a viscous mass that includes rhamnolipids, which make up to 80 % of the biocomplex, as well as alginate and water. The methods of computer simulation of semi-automated selection of the composition of the oil phase and emulsifiers of medicinal or cosmetic emulsions developed in the MO Excel program were used. In modelling processes, the biocomplex PS was studied as an independent emulsifier in o/w type emulsions, as well as a co-emulsifier of this type of emulsions in combination with type II emulsifiers.
Results. The substantiation of the concentration of emulsifiers in the composition of emulsion medicinal and cosmetic products is mainly carried out based on experimental studies; therefore, it requires a long time and is expensive. To reduce the number of technological experiments in the development of emulsion products stabilized by a biocomplex of surfactants based on biocomplex PS, a method of computer simulation of the composition of emulsions in the MO Excel program was developed and used. A method based on the application of the hydrophilic- lipophilic balance system. Two examples of solving specific problems of choosing a complex emulsifier and the composition of the oil phase components of the emulsion product are given.
Conclusions. The use of a semi-automated modelling system provides a reasoned choice of the composition of the oil phase of the emulsion when using the PS biocomplex as an independent emulsifier or the choice of the ratio between the PS biocomplex and the type II emulsifier when using a complex emulsifier and allows rational experimental study
Keywords: emulsions, emulsifiers, rhamnolipids Pseudomonas sp. PS-17, medicines, cosmetics, hydrophilic-lipophilic balance, emulsions, emulsifiers, rhamnolipids Pseudomonas sp. PS-17, medicines, cosmetics, hydrophilic-lipophilic balance
Abstract: Background: Some investigations show that obesity is associated with increase in bone mass due to excessive mechanical exertion. However, these data are contradictory as loss of mineral density of bone tissue and, respectively, the risk of fractures in this population group is higher. The aim of the research was to investigate impact of drug therapy with zoledronic acid on nanostruc- ture of bones in rats with limited mobility and high-calo- rie diet.
Methods: Rats (n = 56) were distributed into three groups: control (n = 18) – standard vivarium conditions, І experi- mental group (n = 18) – rats, which were on a high-calo- rie diet with limited mobility (HCD+LM), ІІ experimental group (n = 18) – HCD+LM+zoledronic acid. Zoledronic acid was injected at the dose 0.025 mg/kg intramuscularly every four weeks for six months. X-ray structure analy- sis, scanning electron microscopy and atomic absorption spectrometry were used for investigation of ultrastructure and quantitative assessment of mineral component loss in the femoral neck.
Results: Obesity and limited mobility reduced the level of the mineral component in the femoral neck (−31.5%) com- pared with control. It is significant that zoledronic acid did not permit decrease in mineral component of the bone throughout the entire experiment compared with group I (+41.8%), and all parameters were higher than in control group (+15%).
Conclusions: Obesity and limited mobility negatively affect mineral bone mass. Zoledronic acid induces increase in the mineral component as a result of remodeling inhibition under conditions of obesity and limited mobility modeling.
The aim of the study management of medical institutions in the context of providing medical and preventive care in conditions of COVID-19 is an urgent research problem because it provides detection of management’s effective mechanism in times of crisis. It was to identify the management’s peculiarities of medical institutions in the context of providing medical and preventive care in conditions of COVID-19. The article uses a qualitative content analysis method, a method of comparison, and a method of analysis of countries’ cases in the context of rendering medical and preventive care in Ukraine, Spain, Italy, Germany, and the Czech Republic. The article identifies the main elements of the health system management mechanism during the pandemic, which includes coordinated work by stakeholders to ensure a coordinated response to the emergency. The mechanism includes the organizational, legal, and financial components of cooperation between agencies and ministries of national, regional level, involvement international organizations in the process of development of policy and tactics, management crisis’ strategies. Strategic documents of the national level are one of the main elements of the management’s system.
Despite the war, or maybe because of it, progress was made in the European integration process: in June 2022, Ukraine entered the status of an applicant for the EU state. Along with this, the requirements remain the same as before, and improving the level of medicine and healthcare is among them. The purpose of writing an academic paper was to familiarize Ukraine’s citizens with equal access to quality medical services, as a result of changes to orient the system and to place the patient in its center. The research methods were analysis, synthesis, generalization, explanation and data qualification. The regional office of the World Health Organization for Europe (WHO / Europe) became the first and main source for the disclosure of the topic outlined (World Health Organization). The present scientific work will reveal the possible consequences of European integration for Ukrainian medicine. It is important to understand that the arguments of this research are not entirely academic, because it is impossible to know when the war will end and whether Ukraine will not remain a buffer zone for the EU countries. Nevertheless, regardless of the development of events, it is important to critically assess the role of the European Union and its interests in Ukraine.
HIGHLIGHTS
The reform of the health care system in accordance with the goals of sustainable development in the EU countries is analyzed.
The research reveals the possible consequences of European integration for Ukrainian medicine. The research reveals the possible consequences of European integration for Ukrainian medicine.
More than 1 month since Russia began its illegal invasion of Ukraine the tragic human suffering and loss of life are clear. Each day brings more death, injuries, and stories of people fighting for their lives. The implications of the war extend beyond the military and civilian casualties. There are geopolitical, financial, infrastructural, and health impacts. And the effects of this war, particularly on health and health care within and outside Ukraine, will continue long after violent conflict ends.
The war has brought immense pressures and demands for the Ukrainian health sector. There have been 3039 civilian casualties recorded, including 104 children and 1075 adults killed as of March 28, 2022.The risk of infectious disease outbreaks, particularly COVID-19, cholera, polio, tuberculosis, and diarrhoeal diseases, is rising as people are forced to shelter in overcrowded spaces with inadequate or no access to water and sanitation facilities.The UN High Commissioner for Refugees stated the war has forced 10 million Ukrainians to flee their homes,of whom about 6·4 millionare displaced internally and in desperate need of urgent aid, treatment for recent injuries and illness, and continued care for chronic conditions. Food shortages are arising because of damage to agricultural infrastructure and disruptions in food supply chains.The risks of mental health and psychosocial deterioration are growing as people face traumatic events and stress from acute conflict.Attacks on and around maternity hospitals mean many women do not have access to the obstetric care they need, increasing the risks of maternal and neonatal morbidity and mortality.It is estimated that more than 2 million children younger than 5 years and pregnant and breastfeeding women in Ukraine are in need of nutrition assistance.There could also be health risks related to potential Russian use of nuclear, chemical, or biological weapons against Ukrainian civilians.