The aim: To analyze the metabolic status of patients with coronary artery disease and nonalcoholic fatty liver disease depending on body mass index.
Materials and methods: The cohort of patients included 107 people with coronary artery disease (CAD), nonalcoholic fatty liver disease (NAFLD) and overweight (n=56) or obesity (n=51). In all patients glucose, insulin, HbA1c, HOMA-IR, hsCRP, transaminases, creatinine, urea, uric acid, lipid profile, anthropometric parameters and ultrasound elastography were measured. Results: During the analysis of serum lipid spectrum in patients with obesity: lower levels of HDL and higher TG concentration compared with patients who had overweight. The insulin level was almost twice as high as in patients with overweight and the HOMA-IR index was 3.49 (2.13;5.78), where as in patients with overweight it was 1.85 (1.28;3,01), p<0.01. In patients with coronary artery disease and overweight, the of hsCRP was 1.92 (1.18;2.98) mg/l and was significantly different from the hsCRP level in obese patients, which was 3.15 (2.64;3.66) mg/l, p=0,004. Conclusions: In patients with coronary artery disease, non-alcoholic fatty liver disease and obesity, the metabolic profile was characterized by a more unfavorable lipid spectrum: lower levels of HDL and higher triglicerid concentration. Carbohydrate metabolism in obese patients included disorders such us impared glucose tolerance, hyperinsulinemia and insulin resistance. There was also a correlation between body mass index with insulin and glycated hemoglobin. Higher concentration hsCRP in obese compared with patients with overweight was observed. This confirms the role of obesity in the patogenesis of coronary artery disease, non-alcoholic fatty liver disease and systemic inflammation.

Abstract.1 New 4-aryl-3-(morpholin-4-yl)-2-arylimino-2,3-dihydrothiazole derivatives 1.1-1.16 were obtained using the Hantzsch reaction by condensation of N-(morpholin-4-yl)-N'-arylthioureas with the corresponding α-bromoacetophenones in alcohols. Synthesized hydrobromides 1.1-1.8 were formed as crystalline precipitates during the boiling of the reaction mixture. Bases 1.9-1.16 were obtained by neutralizing the corresponding hydrobromides with NH4OH solution. It has been proposed a possible mechanism of the reaction that is based on the study of the structure of the synthesized compounds. The structures of the synthesized compounds were confirmed by 1H NMR spectroscopy with its special techniques (NOESY and ROESY experiments). It has been shown the formation of the isomer 4-(4'-chlorophenyl)-3-(morpholin-4-yl)-2-(4'-chlorophenylamino)-2.3-dihydrothiazole on the basis of compound 1.14. Pharmacological screening of synthesized derivatives of 4-aryl-2-arylimino-2,3-dihydrothiazole compounds revealed the analgesic effect in the model of visceral pain caused by the introduction of acetic acid to white mice. The anti-inflammatory effect of the synthesized compounds was evaluated in vivo by reducing limb edema in rats with carrageenan-induced inflammation. Thus, the synthesized compounds have analgesic and anti-inflammatory activity. 

The correct answer is:
C. Pulmonary artery bifurcation into the right and left pulmonary arteries. The abnormality is the patent arterial duct.

Two given videos show models which are viewed in the virtual reality. They are three-dimensional reconstructions of the same vascular area.
In Video 1 (See videos at www.hvt-journal.com), normal anatomy is presented, while in Video 2 (See videos at www.hvt-journal.com) an abnormality is depicted.
Choose the correct answer for the anatomical description and diagnosis:
A. Common carotid artery bifurcation into the internal and external carotid arteries. The abnormality is an atherosclerotic plaque.
B. Bifurcation of the abdominal aorta into two common iliac arteries. The finding is the median sacral artery.
C. Pulmonary artery bifurcation into the right and left pulmonary arteries. The abnormality is the patent arterial duct.
D. Left main coronary artery bifurcation into the left anterior descending artery and circumflex artery. The diagnosis is trifurcation into the left anterior descending, prominent intermediate and left circumflex artery.
E. Renal artery bifurcation in the renal hilum. The diagnosis is renal artery thrombosis

The aim:The aim of the article is to empirically study the features of tolerance to uncertainty in late adulthood in groups of working and retired people and test the hypothesis of the impact of communication in social networks as one of the possible ways to increase mental well-being in this category of people.
Materials and methods: The study was conducted in 2021 in the Lviv region of Ukraine. Forty people aged 60 - 75 were interviewed. Among them there were 20 people with a 40-hour working week and 20 retired people. To assess the level of tolerance to uncertainty, the tolerance scale by D. L. McLain (modified by E.M. Osin) has been used; to determine the level of dependence on social networks, the Bergen Facebook Addiction Scale (having tested 20 people who are retired in the age group 60-75 ) has been applied.
Results: The results of the study showed that: (1) the level of the integrated indicator of “tolerance to uncertainty” is higher among people who work than among those who are retired; (2) people of the age group of 60-75 who work have higher values in all components of the uncertainty tolerance indicator; (3) there is a high interdependence between the expansion of the communication environment through communication in social networks and the level of tolerance to uncertainty among retired people in the age group of 60-75.
Conclusions: People in the age group of 60-75 who work have a greater potential for successful aging due to the higher value of the components of tolerance to uncertainty and their connection to personality traits on which mental well-being depends. The increase in the level of mental well-being of retired people of late adulthood can be achieved through influencing the uncertainty factor: either by employing these people or by actively involving them in communication in social networks.