УДК 616.314.9-002:616.7]-018.2-053.4

Abstract. Аssociation between incidence of caries of temporary teeth and pathology of the musculoskeletal system 
in preschool children, considering biochemical markers of connective tissue metabolism. Bodnaruk N.I.,  Smolyar N.I., Chukhray N.L., Mashkarinets O.O., Gan I.V. The aim is study biochemical markers of connective tissue  metabolism in children with musculoskeletal disorders and their association with dental caries of temporary teeth. There  were examined 232 children at the age of 5 (202 children with musculoskeletal disorders and 30 conditionally healthy  children without somatic pathology). Among children with musculoskeletal disorders 68 (33.66%) had flat feet, 59  (29.21%) – postural impairment and 75 (37.13%) – combined pathology of the musculoskeletal sestem. For further  research, the children were divided into three groups, 30 people in each. Group І included children with pathology of the musculoskeletal system, dental caries, without oxyproline in urine; group ІІ – with pathology of the musculoskeletal  system, dental caries and oxyproline in urine; group ІІІ – with dental caries and without oxyproline in urine. Urinary excretion of glycosaminoglycans using a nephelometric test with cetylpyridinium chloride was determined. The concentration of creatinine in urine was measured in units of weight in the formation of a chromogenic complex of a solution of picric acid with creatinine in an alkaline medium. Dental status was assessed in terms of caries prevalence, deft index and severity of dental caries. The prevalence of caries of temporary teeth in 5-years old children with musculoskeletal disorders was on average 90.6±2.05%, deft index ─ 6.62±0.20, being significantly higher than in children without somatic pathology (respectively 70.83±4.45% and 5.15±0.34, р<0.001). Oxyprolin was detected only in the urine of children with combined pathology of musculoskeletal system (on average 3.53±0.11 units). The excretion rates of glycosaminoglycans in children with pathology of the musculoskeletal system, dental caries and oxyproline in urine (gr.ІІ) were two times higher than the reference range (415.37±15,09 CPCh units / 1 g creatinine, р<0.001). In the absence of oxyproline in urine, both in somatically healthy children (gr. ІІІ) and in children with pathology of the musculoskeletal system (gr. І), the levels of excretion of glycosoaminoglycans were within the reference range (respectively 198.83±10.71 and 203.87±12.52 CPCh units / 1 g creatinine. The levels of daily excretion of creatinine were within the normal range in children of gr. ІІІ (1.17±0.13 g/day; in children of gr. І they were 2.85 times lower (0.41±0.05 g/day, p<0.001); in children of gr. ІІ – 6.5 times lower (0.18±0.02 g/day р<0.001). In children of gr. ІІ, a negative correlation was found between the levels of creatinine and oxyproline (τ= -0.68, p<0.05). The absence of oxyproline in the urine of children of gr. І and ІІІ indicates the absence of collagen decay in their bodies. In children with pathology of the musculoskeletal system against the background of undifferentiated connective tissue dysplasia (gr. ІІ), a strong, positive correlation was found between the deft index and levels of urinary excretion of oxyproline (τ= +0.77, p<0.05) and glycosaminoglycans (τ= +0.90, p<0.05), which indicates that the development of dental caries depends on the severity of the pathology of the musculoskeletal system.

To date, according to statistics, in Ukraine there is an increase in the number of infertile marriages. Many studies have emphasized the male factor of infertility Often, male infertility is the result of a previous infectious disease or an acute genital inflammation. Microorganisms that infect sperm usually persist in the urinary tract as a monoinfection or form associations. Microorganisms in biofilms are able to acquire new, not yet studied, properties. Persistence of pathogens in the urogenital tract of men triggers several mechanisms of the pathological action on sperm, the first of which is the infectious factor, directly related to the adhesion and resulting in a complete or partial decrease in the mobility and deformation of sperm. On the other hand, the development of the inflammatory process as a trigger of an immune response directed simultaneously against the infectious agent and the affected sperm. The increase in the number of leukocytes at the site of inflammation activates the secretion of biological substances which also have a damaging effect on sperm. The generalized data allow drawing a conclusion about the significant influence of opportunistic and pathogenic microorganisms as part of associations or monoinfection on the morphofunctional state of spermatozoa.

Abstract: A combination of systemic antibiotics with scaling may provide an additional advantage over scaling alone in the periodontitis treatment in terms of clinical loss of attachment and change in pocket depth. The use of antibiotics should be justified by a determined need and should not replace adequate local treatment. Different treatment protocols have been proposed, but their indications and efficacy remain controversial. The study aims to analyse the literature on the use of antimicrobial agents for non-surgical periodontal therapy and to compare different protocols for prescribing antimicrobial agents. A search in MEDLINE and EBSCOhost electronic databases was conducted using relevant MeSH words. Targeted studies had to be published within the last five years. Studies were selected based on inclusion and exclusion criteria. Data from selected studies were extracted and analysed. Ten randomized clinical trials were included in the review. The general conclusions of this review indicate a positive effect of antibiotics as an adjunct to non-surgical treatment of chronic periodontitis, regardless of antimicrobial drugs used in the reviewed studies. A prospect for further research is a comparative analysis of the effectiveness of the use of antimicrobial agents and probiotics as an adjunct to the non-surgical treatment of chronic periodontitis.

Keywords: Antimicrobial agents, Chronic periodontitis, Non-surgical treatment of chronic periodontitis, Periodontal pocket, Systemic antibiotics.

The aim was to study the structure, routes and algorithms of telemedical network in Odessa region and its impact on the spread of COVID-19 pandemics.
Materials and methods: We have analysed the data of the official reporting documentation provided by the Department of Healthcare of Odessa region. So the description of legislative acts and structure of telmedical network of Odessa region is given. In more detail, we described functions and capabilities of telmedical network COVID-19 pandemics. 
Conclusions: Studies have shown that Telemedicine can be used in 5 main directions: Triage and decisions regarding hospitalization to hospitals designed for COVID-19 patients or to other hospitals. Outpatient consulting in COVID-19 patients who stay at home. Coordination of activities of different hospitals; provision of specialized consulting. Training of healthcare providers for counter-epidemic measures and management of COVID-19 patients. Routine consulting in patients with chronic disease and in palliative cases. In all this activities significant benefits were founded. But amount of telemedical consultations are quiet low. As in all viral pandemies remote consultations of patients leeds to lowering in amount of infection of COVID-19 patients.
KEY WORDS: COVID-19, Triage, Telemedicine, Remote Consultation, Health Communication

The aim: To improve the effectiveness of treatment of patients with hypertension using metabolic therapy based on the evaluation of endothelial dysfunction indicators, markers of inflammation, and blood lipid spectrum.

Materials and methods: A clinical study was performed with 72 patients (34 male and 38 female) with stage 2 arterial hypertension of 2-3 degrees, admitted to the cardiology department of the municipal non-profit enterprise “Lviv Emergency Clinical Hospital”. The mean age of patients was 44.8±8.5 years. Patients were divided into 2 groups: Group I was taking quercetin in addition to basic therapy (Ramipril/Amlodipine in individually adjusted dose); Group II – had basic therapy following the clinical protocol. The level of nitric oxide, IL-1, IL-6, TNF-a, CRP, seromucoid, blood lipid spectrum was determined.

Results: There is a significant decrease in the NO and CRP levels. There is a decrease in the TNF-a level by 31.27±2.13 (p<0.01) after the treatment of patients with hypertension. The TNF-a level decreased by 22.2±1.13 (p<0.01) with the use of basic therapy. IL-1 decreased significantly in the two groups, but it was more pronounced in group I, by 40.68±1.67 (p<0.01) and 21.4±2.1 in group II (p<0.05). There is a positive change in the blood lipid spectrum, but the changes were more pronounced in the group of patients receiving metabolic therapy.

Conclusions: The use of quercetin (Corvitin, Quertin) in combination therapy with the combined antihypertensive drug containing ramipril/amlodipine (Egis-Hungary) significantly reduces the levels of nitric oxide, CRP, IL-1, and blood lipid spectrum, which reduces the incidence of complications and progression of hypertension.

KEY WORDS: endothelial dysfunction, TNF-a, IL-1, IL-6, CRP, lipid spectrum, hypertension, amlodipine, ramipril, quercetin