Nowadays dermatologist’s arsenal contains numerous pharmacological agents with high efficiency, but achieving the desired results in acne therapy is still not the easiest problem. The undisputed leader in the treatment of acne, taking into account the frequency of prescriptions, effectiveness, active substances as mono- and combined forms, lack of systemic influence, are topical medicines. As a result, groups of the most effective medical agents for acne therapy, features of their use in different forms and degrees of severity, possible side effects and factors that can provoke them, ways to minimize their occurrence without reducing effectiveness were identified.

Today, the use of platelet-rich plasma is increasing in clinical practice in various fields of medicine. The plasma therapy is used by dermatologists, dentists, gynecologists, traumatologists and many other specialists in daily practice. Platelet-rich plasma is actively used in dermatology after its clinical effectiveness has been established. The plasma therapy method alone, as well as in combination with other methods of treatment, has shown advantages in certain skin diseases: androgenetic alopecia, alopecia areata, chronic vitiligo, melasma, inflammatory nail disorders, psoriasis, acne, post-acne and seborrheic dermatitis. Platelet-rich plasma can suppress cytokine release and limit inflammation by interacting with macrophages, improving tissue healing and regeneration, promoting the formation of new capillaries and accelerating epithelialization. Plasma platelets also play an important role in the host’s defense mechanism at the wound site by producing signaling proteins that attract macrophages. Blood plasma also has antimicrobial activity against Escherichia coli, Staphilococcus aureus, Candida albicans and Cryptococcus neoformans.

Cicatricial alopecia is a severe form of hail loss that affects both men and women. As this pathology develops, the hair follicles die completely, therefore, making a correct diagnosis rapidly affects the possibility of preserving the hair follicles that have not yet been damaged. The disease occurs in 3 % of all alopecia patients and is characterized by a rapid hair loss, with focal lesions in different areas of the scalp.

The cause of cicatricial alopecia is not only injuries or burns, but also a number of skin diseases that can start affecting the scalp. The punch biopsy followed by histopathological examination is usually the key research method to make or confirm the final diagnosis of cicatricial alopecia and preserve healthy hair follicles.

Psoriasis affects about 2 % of population. In 30—40 % of occurrences arthropathic psoriasis (AP) is diagnosed and it leads to 11—19 % of disability cases development. The article analyses features of anamnesis, clinical, instrumental and laboratory tests related to arthropathic psoriasis, considers the relationship of probable mechanisms of disease aggravation and progression with the definition of a treatment method influencing the dynamics of a disease course.

There is a trend today to increasing the number of cases of psoriasis, as well as the complication of its forms — erythrodermic states, pustular forms, psoriasis arthropica. Recent studies have demonstrated that psoriasis is often combined with herpesvirus type 1, 2. The interaction of the components of the innate immune response, the cellular and humoral parts of the immune system is carried out with the help of the cytokine network. Therefore, it is necessary to assess the state of chronic herpetic infection in patients with psoriasis depending on the latent or active course, especially with frequent infection activation.