Cicatricial alopecia is a severe form of hail loss that affects both men and women. As this pathology develops, the hair follicles die completely, therefore, making a correct diagnosis rapidly affects the possibility of preserving the hair follicles that have not yet been damaged. The disease occurs in 3 % of all alopecia patients and is characterized by a rapid hair loss, with focal lesions in different areas of the scalp.

The cause of cicatricial alopecia is not only injuries or burns, but also a number of skin diseases that can start affecting the scalp. The punch biopsy followed by histopathological examination is usually the key research method to make or confirm the final diagnosis of cicatricial alopecia and preserve healthy hair follicles.

Psoriasis affects about 2 % of population. In 30—40 % of occurrences arthropathic psoriasis (AP) is diagnosed and it leads to 11—19 % of disability cases development. The article analyses features of anamnesis, clinical, instrumental and laboratory tests related to arthropathic psoriasis, considers the relationship of probable mechanisms of disease aggravation and progression with the definition of a treatment method influencing the dynamics of a disease course.

There is a trend today to increasing the number of cases of psoriasis, as well as the complication of its forms — erythrodermic states, pustular forms, psoriasis arthropica. Recent studies have demonstrated that psoriasis is often combined with herpesvirus type 1, 2. The interaction of the components of the innate immune response, the cellular and humoral parts of the immune system is carried out with the help of the cytokine network. Therefore, it is necessary to assess the state of chronic herpetic infection in patients with psoriasis depending on the latent or active course, especially with frequent infection activation.

The means and dosage forms of topical therapy depend usually on the clinical course pathological process. In recent years, both in the world and in Ukraine, narrowband UVB phototherapy of psoriasis, because of its efficiency, safety and availability has become a technique of choice in the treatment of psoriasis patients with different clinical course. NB UVB therapy method is self-contained and can be used as monotherapy, but combination of emollient, in our view, adds treat certain advantages. The aim of our study was to examine and evaluate the effectiveness of this method phototherapy combination of emollient in the treatment of psoriasis.

Taking into consideration the latest data on psoriasis problems, namely: a number of uncertain links of etiopathogenesis, possible consistency of disorders of immune system, thyroid and skin microbial landscape as well as failure to achieve long-term and controlled remission demonstrate the relevance and feasibility of further research of dermatosis, which will contribute to improving quality of life for patients by using appropriate methods of therapeutic correction. The aim of our research was to study of skin microbial landscape and immune-endocrine parameters as well as improvement of treatment efficiency in patients with different clinical course of psoriasis by using narrowband UVB phototherapy.