Psoriasis affects about 2 % of population. In 30—40 % of occurrences arthropathic psoriasis (AP) is diagnosed and it leads to 11—19 % of disability cases development. The article analyses features of anamnesis, clinical, instrumental and laboratory tests related to arthropathic psoriasis, considers the relationship of probable mechanisms of disease aggravation and progression with the definition of a treatment method influencing the dynamics of a disease course.

There is a trend today to increasing the number of cases of psoriasis, as well as the complication of its forms — erythrodermic states, pustular forms, psoriasis arthropica. Recent studies have demonstrated that psoriasis is often combined with herpesvirus type 1, 2. The interaction of the components of the innate immune response, the cellular and humoral parts of the immune system is carried out with the help of the cytokine network. Therefore, it is necessary to assess the state of chronic herpetic infection in patients with psoriasis depending on the latent or active course, especially with frequent infection activation.

The means and dosage forms of topical therapy depend usually on the clinical course pathological process. In recent years, both in the world and in Ukraine, narrowband UVB phototherapy of psoriasis, because of its efficiency, safety and availability has become a technique of choice in the treatment of psoriasis patients with different clinical course. NB UVB therapy method is self-contained and can be used as monotherapy, but combination of emollient, in our view, adds treat certain advantages. The aim of our study was to examine and evaluate the effectiveness of this method phototherapy combination of emollient in the treatment of psoriasis.

Taking into consideration the latest data on psoriasis problems, namely: a number of uncertain links of etiopathogenesis, possible consistency of disorders of immune system, thyroid and skin microbial landscape as well as failure to achieve long-term and controlled remission demonstrate the relevance and feasibility of further research of dermatosis, which will contribute to improving quality of life for patients by using appropriate methods of therapeutic correction. The aim of our research was to study of skin microbial landscape and immune-endocrine parameters as well as improvement of treatment efficiency in patients with different clinical course of psoriasis by using narrowband UVB phototherapy.

There is a group of coagulation inhibitors, which are antiphospholipid antibodies (APLA). In patients with different phospholipid antibodies, recurrent thrombolytic therapy complications, brain lesions and pregnancy pathology were observed, which allowed identifying APLA syndrome